KEGG   PATHWAY: scot00260
Entry
scot00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Salinivibrio costicola
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
scot00260  Glycine, serine and threonine metabolism
scot00260

Module
scot_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:scot00260]
scot_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:scot00260]
scot_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:scot00260]
scot_M00555  Betaine biosynthesis, choline => betaine [PATH:scot00260]
scot_M00621  Glycine cleavage system [PATH:scot00260]
scot_M00919  Ectoine degradation, ectoine => aspartate [PATH:scot00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salinivibrio costicola [GN:scot]
Gene
HBA18_00655  [KO:K10674] [EC:1.14.11.55]
HBA18_00865  [KO:K00639] [EC:2.3.1.29]
HBA18_00870  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
HBA18_00880  gpmM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HBA18_01025  [KO:K12525] [EC:2.7.2.4 1.1.1.3]
HBA18_01080  [KO:K00382] [EC:1.8.1.4]
HBA18_01555  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
HBA18_01560  [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
HBA18_02385  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HBA18_02410  [KO:K00865] [EC:2.7.1.165]
HBA18_02750  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
HBA18_02755  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
HBA18_02760  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HBA18_02790  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HBA18_02830  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HBA18_04685  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HBA18_04690  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
HBA18_05295  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
HBA18_05495  [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HBA18_05590  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HBA18_05595  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HBA18_06735  [KO:K02204] [EC:2.7.1.39]
HBA18_07705  [KO:K01752] [EC:4.3.1.17]
HBA18_08145  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
HBA18_08645  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HBA18_09600  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HBA18_10000  [KO:K00133] [EC:1.2.1.11]
HBA18_10480  [KO:K00600] [EC:2.1.2.1]
HBA18_10960  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
HBA18_11010  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
HBA18_11840  [KO:K00018] [EC:1.1.1.29]
HBA18_12065  alr; alanine racemase [KO:K25317]
HBA18_12710  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
HBA18_13305  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
HBA18_14650  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
HBA18_14655  doeB; N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
HBA18_14670  [KO:K15786] [EC:1.2.1.-]
HBA18_14675  [KO:K15785] [EC:2.6.1.76]
HBA18_15045  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HBA18_15055  [KO:K01752] [EC:4.3.1.17]
HBA18_15060  [KO:K00600] [EC:2.1.2.1]
HBA18_15065  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HBA18_15070  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HBA18_15380  [KO:K01758] [EC:4.4.1.1]
HBA18_16485  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
HBA18_16490  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
HBA18_16495  [KO:K06720] [EC:4.2.1.108]
HBA18_16500  [KO:K00928] [EC:2.7.2.4]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
scot00010  Glycolysis / Gluconeogenesis
scot00020  Citrate cycle (TCA cycle)
scot00230  Purine metabolism
scot00250  Alanine, aspartate and glutamate metabolism
scot00270  Cysteine and methionine metabolism
scot00290  Valine, leucine and isoleucine biosynthesis
scot00300  Lysine biosynthesis
scot00330  Arginine and proline metabolism
scot00460  Cyanoamino acid metabolism
scot00470  D-Amino acid metabolism
scot00564  Glycerophospholipid metabolism
scot00600  Sphingolipid metabolism
scot00620  Pyruvate metabolism
scot00630  Glyoxylate and dicarboxylate metabolism
scot00640  Propanoate metabolism
scot00680  Methane metabolism
scot00860  Porphyrin metabolism
scot00920  Sulfur metabolism
KO pathway
ko00260   

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