KEGG   PATHWAY: seb00260
Entry
seb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Salmonella enterica subsp. enterica serovar Typhimurium ST4/74
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
seb00260  Glycine, serine and threonine metabolism
seb00260

Module
seb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:seb00260]
seb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:seb00260]
seb_M00621  Glycine cleavage system [PATH:seb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Salmonella enterica subsp. enterica serovar Typhimurium ST4/74 [GN:seb]
Gene
STM474_0002  thrA; Bifunctional aspartokinase/homoserine dehydrogenase 1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
STM474_0003  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
STM474_0004  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
STM474_0162  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
STM474_0546  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
STM474_0797  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
STM474_0921  ltaA; L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
STM474_0963  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
STM474_1130  ycdW; putative oxidoreductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
STM474_1522  ydfG; 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
STM474_1743  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
STM474_1744  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
STM474_1848  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
STM474_2285  [KO:K01752] [EC:4.3.1.17]
STM474_2659  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
STM474_2765  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
STM474_3104  [KO:K00865] [EC:2.7.1.165]
STM474_3116  sdaB; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
STM474_3162  ygeA; putative racemase [KO:K25316]
STM474_3200  gcvP; glycine cleavage complex protein P, glycine decarboxylase [KO:K00281] [EC:1.4.4.2]
STM474_3201  gcvH; glycine cleavage system protein H [KO:K02437]
STM474_3202  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
STM474_3209  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
STM474_3394  tdcG; L-serine deaminase [KO:K01752] [EC:4.3.1.17]
STM474_3398  tdcB; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
STM474_3404  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
STM474_3706  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
STM474_3818  yiaE; 2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
STM474_3877  pmgI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
STM474_3881  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
STM474_3882  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
STM474_3977  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
STM474_4083  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
STM474_4285  metL; bifunctional aspartate kinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
STM474_4414  lysC; aspartate kinase III [KO:K00928] [EC:2.7.2.4]
STM474_4784  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
STM474_4791  gpmB; phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
seb00010  Glycolysis / Gluconeogenesis
seb00020  Citrate cycle (TCA cycle)
seb00230  Purine metabolism
seb00250  Alanine, aspartate and glutamate metabolism
seb00270  Cysteine and methionine metabolism
seb00290  Valine, leucine and isoleucine biosynthesis
seb00300  Lysine biosynthesis
seb00330  Arginine and proline metabolism
seb00460  Cyanoamino acid metabolism
seb00470  D-Amino acid metabolism
seb00564  Glycerophospholipid metabolism
seb00600  Sphingolipid metabolism
seb00620  Pyruvate metabolism
seb00630  Glyoxylate and dicarboxylate metabolism
seb00640  Propanoate metabolism
seb00680  Methane metabolism
seb00860  Porphyrin metabolism
seb00920  Sulfur metabolism
KO pathway
ko00260   

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