KEGG   PATHWAY: smac00230
Entry
smac00230                   Pathway                                
Name
Purine metabolism - Serratia marcescens subsp. marcescens Db11
Class
Metabolism; Nucleotide metabolism
Pathway map
smac00230  Purine metabolism
smac00230

Module
smac_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:smac00230]
smac_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:smac00230]
smac_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:smac00230]
smac_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:smac00230]
smac_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:smac00230]
Other DBs
GO: 0006163 0042278
Organism
Serratia marcescens subsp. marcescens Db11 [GN:smac]
Gene
SMDB11_0034  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
SMDB11_0090  guaC; GMP reductase [KO:K00364] [EC:1.7.1.7]
SMDB11_0104  dgt; deoxyguanosine triphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
SMDB11_0109  relA; (p)ppGpp synthetase I/GTP pyrophosphokinase [KO:K00951] [EC:2.7.6.5]
SMDB11_0110  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
SMDB11_0128  cysD; sulfate adenylyltransferase, subunit 2 [KO:K00957] [EC:2.7.7.4]
SMDB11_0129  cysN; sulfate adenylyltransferase, subunit 1 [KO:K00956] [EC:2.7.7.4]
SMDB11_0130  cysC; adenosine 5'-phosphosulfate kinase [KO:K00860] [EC:2.7.1.25]
SMDB11_0139  surE; broad specificity 5'(3')-nucleotidase andpolyphosphatase [KO:K03787] [EC:3.1.3.5 3.1.3.6]
SMDB11_0185  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
SMDB11_0221  gpt; guanine-hypoxanthine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
SMDB11_0293  [KO:K09913] [EC:2.4.2.1 2.4.2.2]
SMDB11_0377  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
SMDB11_0382  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
SMDB11_0387  gsk; inosine/guanosine kinase [KO:K00892] [EC:2.7.1.73]
SMDB11_0391  ushA; bifunctional UDP-sugarhydrolase/5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
SMDB11_0407  purK; N5-carboxyaminoimidazole ribonucleotidesynthase [KO:K01589] [EC:6.3.4.18]
SMDB11_0408  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
SMDB11_0469  nagD; UMP phosphatase [KO:K02566] [EC:3.1.3.5]
SMDB11_0484  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
SMDB11_0496  [KO:K01120] [EC:3.1.4.17]
SMDB11_0514  [KO:K01119] [EC:3.1.4.16 3.1.3.6]
SMDB11_1262  prsA; phosphoribosylpyrophosphate synthase [KO:K00948] [EC:2.7.6.1]
SMDB11_1303  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
SMDB11_1522  add; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
SMDB11_1564  guaD; guanine aminohydrolase [KO:K01487] [EC:3.5.4.3]
SMDB11_1810  [KO:K01951] [EC:6.3.5.2]
SMDB11_2079  purT; phosphoribosylglycinamide formyltransferase 2 [KO:K08289] [EC:6.3.1.21]
SMDB11_2397  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
SMDB11_2632  [KO:K06952] [EC:3.1.3.89]
SMDB11_2651  [KO:K03651] [EC:3.1.4.53]
SMDB11_2667  nrdA; ribonucleoside diphosphate reductase 1,alphasubunit [KO:K00525] [EC:1.17.4.1]
SMDB11_2668  nrdB; ribonucleoside diphosphate reductase 1,betasubunit, ferritin-like protein [KO:K00526] [EC:1.17.4.1]
SMDB11_2703  [KO:K08722] [EC:3.1.3.89]
SMDB11_2728  purF; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
SMDB11_2902  purC; phosphoribosylaminoimidazole-succinocarboxamidesynthetase [KO:K01923] [EC:6.3.2.6]
SMDB11_2925  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
SMDB11_2926  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
SMDB11_2935  ppx; exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SMDB11_2990  guaA; GMP synthetase [KO:K01951] [EC:6.3.5.2]
SMDB11_2991  guaB; IMP dehydrogenase [KO:K00088] [EC:1.1.1.205]
SMDB11_3008  ndk; multifunctional nucleoside diphosphatekinaseand apyrimidinic endonuclease and3'-phosphodiesterase [KO:K00940] [EC:2.7.4.6]
SMDB11_3042  purL; phosphoribosylformyl-glycineamide synthetase [KO:K01952] [EC:6.3.5.3]
SMDB11_3113  nrdE; ribonucleoside-diphosphate reductase 2,alphasubunit [KO:K00525] [EC:1.17.4.1]
SMDB11_3114  nrdF; ribonucleoside-diphosphate reductase 2,betasubunit, ferritin-like protein [KO:K00526] [EC:1.17.4.1]
SMDB11_3192  [KO:K06966] [EC:3.2.2.10 3.2.2.-]
SMDB11_3410  hpt; hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
SMDB11_3441  rdgB; dITP/XTP pyrophosphatase [KO:K01519] [EC:3.6.1.66]
SMDB11_3494  xapA; xanthosine phosphorylase [KO:K03783] [EC:2.4.2.1]
SMDB11_3506  icc; putative cyclic 3',5'-adenosine monophosphatephosphodiesterase [KO:K03651] [EC:3.1.4.53]
SMDB11_3508  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
SMDB11_3552  [KO:K01951] [EC:6.3.5.2]
SMDB11_3635  iunH; inosine-uridine preferring nucleoside hydrolase [KO:K25589]
SMDB11_3858  nudE; ADP compounds hydrolase [KO:K08312] [EC:3.6.1.-]
SMDB11_3860  [KO:K20881] [EC:3.1.3.-]
SMDB11_4079  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
SMDB11_4081  spoT; bifunctional (p)ppGpp synthetaseII/guanosine-3',5'-bis pyrophosphate3'-pyrophosphohydrolase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
SMDB11_4261  gppA; guanosine pentaphosphatase/exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SMDB11_4283  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
SMDB11_4396  purD; phosphoribosylglycinamidesynthetase phosphoribosylamine-glycine ligase [KO:K01945] [EC:6.3.4.13]
SMDB11_4397  purH; fused IMPcyclohydrolase/phosphoribosylaminoimidazolecarboxamidef ormyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
SMDB11_4487  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
SMDB11_4505  cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
SMDB11_4595  nrdD; anaerobic ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
SMDB11_4742  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
SMDB11_4743  deoD; purine-nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
SMDB11_4757  [KO:K01529]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
smac00030  Pentose phosphate pathway
smac00220  Arginine biosynthesis
smac00250  Alanine, aspartate and glutamate metabolism
smac00260  Glycine, serine and threonine metabolism
smac00340  Histidine metabolism
smac00630  Glyoxylate and dicarboxylate metabolism
smac00730  Thiamine metabolism
smac00740  Riboflavin metabolism
smac00790  Folate biosynthesis
KO pathway
ko00230   

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