KEGG PATHWAY: spo00270

PATHWAY: spo00270

Entry

spo00270                    Pathway

Name

Cysteine and methionine metabolism - Schizosaccharomyces pombe (fission yeast)

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

spo00270

Cysteine and methionine metabolism

Module

spo_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:spo00270]

spo_M00021

Cysteine biosynthesis, serine => cysteine [PATH:spo00270]

spo_M00034

Methionine salvage pathway [PATH:spo00270]

Other DBs

GO:	0006534 0006555

Organism

Schizosaccharomyces pombe (fission yeast) [GN:spo]

Gene

2542932

SPOM_SPAC1039.08; serine acetyltransferase [KO:K00640] [EC:2.3.1.30]

2542583

cys12; cysteine synthase-like protein Cys12 [KO:K01738] [EC:2.5.1.47]

2540946

cys11; cysteine synthase [KO:K01738] [EC:2.5.1.47]

2540849

met17; homocysteine synthase Met17 [KO:K17069] [EC:2.5.1.49 2.5.1.47]

2539019

cbl1; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

2543585

met26; homocysteine methyltransferase Met26 [KO:K00549] [EC:2.1.1.14]

2539943

sam1; S-adenosylmethionine synthetase [KO:K00789] [EC:2.5.1.6]

2541338

spe2; S-adenosylmethionine decarboxylase proenzyme Spe2 [KO:K01611] [EC:4.1.1.50]

2539919

srm1; spermidine synthase [KO:K00797] [EC:2.5.1.16]

2542316

mta1; S-methyl-5-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]

2540540

mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

2542010

mde1; 5'-methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

2543661

utr4; methionine salvage haloacid dehalogenase-like hydrolase [KO:K09880] [EC:3.1.3.77]

2541231

adi1; acireductone dioxygenase family protein [KO:K08967] [EC:1.13.11.53 1.13.11.54]

2543350

SPOM_SPAC56E4.03; aromatic aminotransferase [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]

2540092

SPOM_SPBC1773.13; aromatic aminotransferase [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]

2538779

SPOM_SPCC569.07; aromatic aminotransferase [KO:K00838] [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]

2541218

SPOM_SPBC8D2.18C; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]

2543564

SPOM_SPAC922.03; 1-aminocyclopropane-1-carboxylate deaminase [KO:K01505] [EC:3.5.99.7]

2540602

hom3; aspartate kinase [KO:K00928] [EC:2.7.2.4]

2539267

hom2; aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

2541148

hom6; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

2540857

thr1; homoserine kinase [KO:K00872] [EC:2.7.1.39]

2540848

met6; homoserine O-acetyltransferase Met6 [KO:K00641] [EC:2.3.1.31 2.3.1.46]

2539747

met3; cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]

2540831

eca39; branched chain amino acid aminotransferase Eca39 [KO:K00826] [EC:2.6.1.42]

2541881

gcs1; glutamate-cysteine ligase Gcs1 [KO:K11204] [EC:6.3.2.2]

2539059

gcs2; glutamate-cysteine ligase regulatory subunit Gcs2 [KO:K11205]

2542896

gsa1; glutathione synthetase large and small subunit Gsa1 [KO:K21456] [EC:6.3.2.3]

2543020

caa1; aspartate aminotransferase [KO:K14454] [EC:2.6.1.1]

2541186

maa1; aspartate aminotransferase Maa1 [KO:K14455] [EC:2.6.1.1]

5802714

tum1; thiosulfate sulfurtransferase Tum1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]

2542569

SPOM_SPAC186.08C; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

2538766

mdh1; malate dehydrogenase [KO:K00026] [EC:1.1.1.37]

2539490

ser3; D-3 phosphoglycerate dehydrogenase Ser3 [KO:K00058] [EC:1.1.1.95 1.1.1.399]

2542269

ser1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01102

O-Phospho-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors