KEGG   PATHWAY: spsd00260
Entry
spsd00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Staphylococcus shinii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
spsd00260  Glycine, serine and threonine metabolism
spsd00260

Module
spsd_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:spsd00260]
spsd_M00555  Betaine biosynthesis, choline => betaine [PATH:spsd00260]
spsd_M00621  Glycine cleavage system [PATH:spsd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Staphylococcus shinii [GN:spsd]
Gene
JMB28_07700  aspartate kinase [KO:K00928] [EC:2.7.2.4]
JMB28_08090  aspartate kinase [KO:K00928] [EC:2.7.2.4]
JMB28_07695  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
JMB28_08085  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
JMB28_08075  homoserine kinase [KO:K00872] [EC:2.7.1.39]
JMB28_08080  threonine synthase [KO:K01733] [EC:4.2.3.1]
JMB28_04570  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
JMB28_01565  glycerate kinase [KO:K00865] [EC:2.7.1.165]
JMB28_10680  glycerate kinase [KO:K00865] [EC:2.7.1.165]
JMB28_12910  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
JMB28_03035  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
JMB28_10480  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
JMB28_06115  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
JMB28_12005  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
JMB28_07005  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
JMB28_07010  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
JMB28_07000  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
JMB28_07100  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
JMB28_09200  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
JMB28_10195  gcvH; glycine cleavage system protein GcvH [KO:K02437]
JMB28_01690  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
JMB28_01685  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
JMB28_01925  bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
JMB28_08615  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
JMB28_08620  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
JMB28_04825  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
JMB28_02815  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
JMB28_07780  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
JMB28_07785  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
spsd00010  Glycolysis / Gluconeogenesis
spsd00020  Citrate cycle (TCA cycle)
spsd00230  Purine metabolism
spsd00250  Alanine, aspartate and glutamate metabolism
spsd00270  Cysteine and methionine metabolism
spsd00290  Valine, leucine and isoleucine biosynthesis
spsd00300  Lysine biosynthesis
spsd00330  Arginine and proline metabolism
spsd00460  Cyanoamino acid metabolism
spsd00470  D-Amino acid metabolism
spsd00564  Glycerophospholipid metabolism
spsd00600  Sphingolipid metabolism
spsd00620  Pyruvate metabolism
spsd00630  Glyoxylate and dicarboxylate metabolism
spsd00640  Propanoate metabolism
spsd00680  Methane metabolism
spsd00860  Porphyrin metabolism
spsd00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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