KEGG   PATHWAY: spu00983
Entry
spu00983                    Pathway                                
Name
Drug metabolism - other enzymes - Strongylocentrotus purpuratus (purple sea urchin)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
spu00983  Drug metabolism - other enzymes
spu00983

Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
584371  hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
752101  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
115919533  inosine-5'-monophosphate dehydrogenase 1b-like isoform X1 [KO:K00088] [EC:1.1.1.205]
578500  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
582278  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
753964  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
100892034  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
754275  thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
100893811  probable thiopurine S-methyltransferase isoform X2 [KO:K00569] [EC:2.1.1.67]
590906  probable thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
105444398  probable thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
576712  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
588814  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
115918813  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
585597  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
756453  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
583647  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
578573  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
592958  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
593427  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
592078  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
578628  UDP-glucuronosyltransferase 1-8 [KO:K00699] [EC:2.4.1.17]
764059  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
755955  UDP-glucuronosyltransferase 2B18-like [KO:K00699] [EC:2.4.1.17]
115922271  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
580284  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
578924  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
589187  UDP-glucuronosyltransferase 2C1 isoform X1 [KO:K00699] [EC:2.4.1.17]
582057  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
115920758  UDP-glucuronosyltransferase 1-7C-like [KO:K00699] [EC:2.4.1.17]
581862  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
100893272  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
592931  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
582456  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
100892570  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
586865  UDP-glucuronosyltransferase 2C1 isoform X2 [KO:K00699] [EC:2.4.1.17]
115917912  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
100888948  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
575220  UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]
100893671  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
105444861  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
100893231  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
115918426  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
581792  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
115919873  UDP-glucuronosyltransferase 1-4-like [KO:K00699] [EC:2.4.1.17]
581841  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
580846  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
592305  UDP-glucuronosyltransferase 1-2-like [KO:K00699] [EC:2.4.1.17]
582989  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
582390  UDP-glucuronosyltransferase 1-6-like [KO:K00699] [EC:2.4.1.17]
591823  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
105439455  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
100889303  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
578623  UDP-glucuronosyltransferase 2B1 isoform X3 [KO:K00699] [EC:2.4.1.17]
115924776  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
593640  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
580789  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
115925289  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
582820  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
115926435  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
105444322  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
115926442  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
115926443  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
115926445  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
115926714  UDP-glucuronosyltransferase 1-1-like [KO:K00699] [EC:2.4.1.17]
584438  UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
575738  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
105443756  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
581741  UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]
581857  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
585947  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
100892045  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
589827  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
591053  UDP-glucuronosyltransferase 1-2 [KO:K00699] [EC:2.4.1.17]
586804  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
115928711  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
100888011  UDP-glucuronosyltransferase 2B1 [KO:K00699] [EC:2.4.1.17]
115918951  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
575689  beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
580762  cytidine deaminase [KO:K01489] [EC:3.5.4.5]
592241  thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
575768  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
579662  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
115918887  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
585985  beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
583868  uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
115917959  uridine phosphorylase 2-like [KO:K00757] [EC:2.4.2.3]
588945  uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
583574  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
579588  thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
583951  thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
580407  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
115918764  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
581681  UMP-CMP kinase isoform X1 [KO:K13800] [EC:2.7.4.14]
581431  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
577596  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
594140  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
594617  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
590350  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
583346  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
105438171  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
574856  probable deoxyuridine 5'-triphosphate nucleotidohydrolase [KO:K01520] [EC:3.6.1.23]
115919171  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
579110  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
754063  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
583081  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
579788  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
574614  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
584003  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
588493  microsomal glutathione S-transferase 3 isoform X2 [KO:K00799] [EC:2.5.1.18]
581106  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
574739  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
578378  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
587859  glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100893229  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
574676  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
756610  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
591844  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
579911  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
591076  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
753016  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
754437  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
105436784  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
115929465  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
593100  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
593456  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
587704  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
582141  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
590176  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115920029  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115917905  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
588398  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
589776  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
115926743  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115918827  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115926457  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
115918233  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
105443894  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
587401  glutathione S-transferase alpha M14-like [KO:K00799] [EC:2.5.1.18]
115927915  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
115927845  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
582092  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
585297  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
579729  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
587669  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
589095  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
593058  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
593074  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
593086  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
588420  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
581044  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
587692  glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]
580662  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
115918957  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
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Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
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Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
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Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
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Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
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J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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