KEGG   PATHWAY: stry00260
Entry
stry00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces sp. S6
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
stry00260  Glycine, serine and threonine metabolism
stry00260

Module
stry_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:stry00260]
stry_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:stry00260]
stry_M00555  Betaine biosynthesis, choline => betaine [PATH:stry00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces sp. S6 [GN:stry]
Gene
EQG64_15400  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EQG64_10120  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EQG64_15395  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EQG64_18095  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
EQG64_19450  threonine synthase [KO:K01733] [EC:4.2.3.1]
EQG64_24910  threonine synthase [KO:K01733] [EC:4.2.3.1]
EQG64_02125  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EQG64_25680  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EQG64_19160  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
EQG64_25895  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EQG64_20160  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
EQG64_05835  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EQG64_28830  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
EQG64_28825  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
EQG64_25685  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EQG64_08860  amidinotransferase [KO:K00613] [EC:2.1.4.1]
EQG64_30295  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EQG64_28425  choline oxidase [KO:K17755] [EC:1.1.3.17]
EQG64_26620  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
EQG64_12535  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
EQG64_17380  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
EQG64_25675  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EQG64_06925  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EQG64_06930  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EQG64_06105  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
EQG64_12880  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
EQG64_06115  ectoine synthase [KO:K06720] [EC:4.2.1.108]
EQG64_12885  ectoine synthase [KO:K06720] [EC:4.2.1.108]
EQG64_15530  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
EQG64_06120  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
EQG64_10900  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
stry00010  Glycolysis / Gluconeogenesis
stry00020  Citrate cycle (TCA cycle)
stry00230  Purine metabolism
stry00250  Alanine, aspartate and glutamate metabolism
stry00270  Cysteine and methionine metabolism
stry00290  Valine, leucine and isoleucine biosynthesis
stry00300  Lysine biosynthesis
stry00330  Arginine and proline metabolism
stry00460  Cyanoamino acid metabolism
stry00470  D-Amino acid metabolism
stry00564  Glycerophospholipid metabolism
stry00600  Sphingolipid metabolism
stry00620  Pyruvate metabolism
stry00630  Glyoxylate and dicarboxylate metabolism
stry00640  Propanoate metabolism
stry00680  Methane metabolism
stry00860  Porphyrin metabolism
stry00920  Sulfur metabolism
KO pathway
ko00260   
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