KEGG   PATHWAY: stt00540Help
Entry
stt00540                    Pathway                                

Name
Lipopolysaccharide biosynthesis - Salmonella enterica subsp. enterica serovar Typhi Ty2
Class
09100 Metabolism; 09107 Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
stt00540  Lipopolysaccharide biosynthesis
stt00540

Ortholog table
Module
stt_M00060  Lipopolysaccharide biosynthesis, KDO2-lipid A [PATH:stt00540]
stt_M00063  CMP-KDO biosynthesis [PATH:stt00540]
stt_M00064  ADP-L-glycero-D-manno-heptose biosynthesis [PATH:stt00540]
stt_M00080  Lipopolysaccharide biosynthesis, inner core => outer core => O-antigen [PATH:stt00540]
Other DBs
BSID: 11979
GO: 0009103
Organism
Salmonella enterica subsp. enterica serovar Typhi Ty2 [GN:stt]
Gene
t0229  lpxA; acyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine O-acyltransferase [KO:K00677] [EC:2.3.1.129]
t0138  lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [KO:K02535] [EC:3.5.1.108]
t0227  lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [KO:K02536] [EC:2.3.1.191]
t2326  ybbF; conserved hypothetical protein [KO:K03269] [EC:3.6.1.54]
t0230  lpxB; lipid-A-disaccharide synthase [KO:K00748] [EC:2.4.1.182]
t1949  lpxK; tetraacyldisaccharide 4'-kinase [KO:K00912] [EC:2.7.1.130]
t3232  conserved hypothetical protein [KO:K06041] [EC:5.3.1.13]
t1104  kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase [KO:K01627] [EC:2.5.1.55]
t3233  conserved hypothetical protein [KO:K03270] [EC:3.1.3.45]
t1946  kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]
t3794  kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [KO:K02527] [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
t1765  htrB; lipid A biosynthesis lauroyl acyltransferase [KO:K02517] [EC:2.3.1.241]
t0988  msbB; lipid A acyltransferase [KO:K02560] [EC:2.3.1.243]
t2540  gmhA; phosphoheptose isomerase [KO:K03271] [EC:5.3.1.28]
t3120  rfaE; ADP-heptose synthase [KO:K03272] [EC:2.7.7.70 2.7.1.167]
t0251  yaeD; conserved hypothetical protein [KO:K03273] [EC:3.1.3.83 3.1.3.82]
t3809  rfaD; ADP-L-Glycero-D-mannoheptose-6-epimerase [KO:K03274] [EC:5.1.3.20]
t3804  waaZ; lipopolysaccharide core biosynthesis protein RfaZ [KO:K12981] [EC:2.4.99.-]
t3807  waaC; lipopolysaccharide heptosyltransferase-1 [KO:K02841] [EC:2.4.-.-]
t3808  waaF; ADP-heptose-LPS heptosyltransferase II [KO:K02843] [EC:2.4.-.-]
t3796  waaG; lipopolysaccharide core biosynthesis protein [KO:K02844] [EC:2.4.1.-]
t3803  waaY; lipopolysaccharide core biosynthesis protein [KO:K02850] [EC:2.7.1.-]
t3797  waaP; lipopolysaccharide core biosynthesis protein [KO:K02848] [EC:2.7.1.-]
t3795  waaQ; lipopolysaccharide core biosynthesis protein [KO:K02849] [EC:2.4.-.-]
t3800  waaB; lipopolysaccharide 1,6-galactosyltransferase [KO:K02840] [EC:2.4.1.-]
t3879  yhjW; putative membrane protein [KO:K12975] [EC:2.7.8.42]
t3506  yijP; putative membrane protein [KO:K19353] [EC:2.7.8.-]
t3801  waaI; lipopolysaccharide 1,3-galactosyltransferase [KO:K03278] [EC:2.4.1.44]
t3802  waaJ; lipopolysaccharide 1,2-glucosyltransferase [KO:K03279] [EC:2.4.1.58]
t3805  waaK; lipopolysaccharide 1,2-N-acetylglucosaminetransferase [KO:K03280] [EC:2.4.1.56]
t3806  waaL; O-antigen ligase [KO:K02847] [EC:2.4.1.-]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00199  D-Ribulose 5-phosphate
C00229  Acyl-carrier protein
C01112  D-Arabinose 5-phosphate
C01187  3-Deoxy-D-manno-octulosonate
C04121  CMP-3-deoxy-D-manno-octulosonate
C04478  3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  Lipid X
C04919  2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  Lipid A disaccharide
C05223  Dodecanoyl-[acyl-carrier protein]
C05382  Sedoheptulose 7-phosphate
C05761  Tetradecanoyl-[acp]
C06022  UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
C06026  Di[3-deoxy-D-manno-octulosonyl]-lipid A
C06251  Lauroyl-KDO2-lipid IV(A)
C06397  ADP-D-glycero-beta-D-manno-heptose
C06398  ADP-L-glycero-beta-D-manno-heptose
C07836  D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
DOI:10.1046/j.1365-2958.1998.01063.x
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
DOI:10.1128/JB.184.2.363-369.2002
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
DOI:10.1016/S0966-842X(98)01230-X
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)
KO pathway
ko00540   
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