KEGG   PATHWAY: svio00260
Entry
svio00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Streptomyces violascens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
svio00260  Glycine, serine and threonine metabolism
svio00260

Module
svio_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:svio00260]
svio_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:svio00260]
svio_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:svio00260]
svio_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:svio00260]
svio_M00621  Glycine cleavage system [PATH:svio00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Streptomyces violascens [GN:svio]
Gene
HWN34_14215  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HWN34_14210  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HWN34_21720  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HWN34_08075  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HWN34_08065  homoserine kinase [KO:K00872] [EC:2.7.1.39]
HWN34_07685  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
HWN34_08070  threonine synthase [KO:K01733] [EC:4.2.3.1]
HWN34_12620  threonine synthase [KO:K01733] [EC:4.2.3.1]
HWN34_01465  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HWN34_07480  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HWN34_03210  glycerate kinase [KO:K00865] [EC:2.7.1.165]
HWN34_23920  glycerate kinase [KO:K00865] [EC:2.7.1.165]
HWN34_17250  phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
HWN34_10915  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
HWN34_07260  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HWN34_12035  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
HWN34_25315  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HWN34_27685  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
HWN34_27575  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HWN34_07470  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HWN34_04090  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HWN34_23755  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HWN34_07475  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HWN34_16530  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HWN34_02430  FAD-dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
HWN34_03205  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HWN34_18035  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HWN34_06565  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HWN34_06600  gamma-aminobutyraldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HWN34_19665  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
HWN34_10610  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
HWN34_15175  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
HWN34_07485  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HWN34_01415  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
HWN34_16785  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
HWN34_20420  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
HWN34_03275  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HWN34_24465  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HWN34_24460  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HWN34_06010  diaminobutyrate--2-oxoglutarate transaminase family protein [KO:K00836] [EC:2.6.1.76]
HWN34_13180  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
HWN34_25050  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
HWN34_13160  L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
HWN34_25055  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
HWN34_25045  ectoine synthase [KO:K06720] [EC:4.2.1.108]
HWN34_25040  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
HWN34_21175  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
HWN34_24575  aminotransferase class V-fold PLP-dependent enzyme [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
svio00010  Glycolysis / Gluconeogenesis
svio00020  Citrate cycle (TCA cycle)
svio00230  Purine metabolism
svio00250  Alanine, aspartate and glutamate metabolism
svio00270  Cysteine and methionine metabolism
svio00290  Valine, leucine and isoleucine biosynthesis
svio00300  Lysine biosynthesis
svio00330  Arginine and proline metabolism
svio00460  Cyanoamino acid metabolism
svio00470  D-Amino acid metabolism
svio00564  Glycerophospholipid metabolism
svio00600  Sphingolipid metabolism
svio00620  Pyruvate metabolism
svio00630  Glyoxylate and dicarboxylate metabolism
svio00640  Propanoate metabolism
svio00680  Methane metabolism
svio00860  Porphyrin metabolism
svio00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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