KEGG   PATHWAY: thw00260
Entry
thw00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Thioclava nitratireducens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
thw00260  Glycine, serine and threonine metabolism
thw00260

Module
thw_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:thw00260]
thw_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:thw00260]
thw_M00555  Betaine biosynthesis, choline => betaine [PATH:thw00260]
thw_M00621  Glycine cleavage system [PATH:thw00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Thioclava nitratireducens [GN:thw]
Gene
BMG03_03745  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BMG03_03820  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BMG03_14675  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BMG03_06965  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BMG03_03675  threonine synthase [KO:K01733] [EC:4.2.3.1]
BMG03_08555  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BMG03_17365  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BMG03_15900  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BMG03_14445  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
BMG03_01895  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BMG03_19710  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BMG03_15465  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BMG03_00735  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BMG03_00730  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BMG03_00720  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BMG03_12510  5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
BMG03_05790  amine oxidase [KO:K00274] [EC:1.4.3.4]
BMG03_06955  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BMG03_06945  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BMG03_07570  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BMG03_08915  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BMG03_06615  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BMG03_06950  glycine cleavage system protein H [KO:K02437]
BMG03_09810  creatininase [KO:K08688] [EC:3.5.3.3]
BMG03_13265  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BMG03_13635  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BMG03_13640  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BMG03_15675  sorbosone dehydrogenase [KO:K00130] [EC:1.2.1.8]
BMG03_09465  homocysteine methyltransferase [KO:K00544] [EC:2.1.1.5]
BMG03_16345  diguanylate cyclase [KO:K00315] [EC:1.5.8.4]
BMG03_15125  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BMG03_15135  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BMG03_15120  hypothetical protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BMG03_15130  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BMG03_07155  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BMG03_01425  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BMG03_16830  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BMG03_11700  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
BMG03_03810  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
BMG03_03805  diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
BMG03_03815  L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
BMG03_16185  ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
BMG03_11290  hypothetical protein [KO:K15785] [EC:2.6.1.76]
BMG03_11285  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
thw00010  Glycolysis / Gluconeogenesis
thw00020  Citrate cycle (TCA cycle)
thw00230  Purine metabolism
thw00250  Alanine, aspartate and glutamate metabolism
thw00270  Cysteine and methionine metabolism
thw00290  Valine, leucine and isoleucine biosynthesis
thw00300  Lysine biosynthesis
thw00330  Arginine and proline metabolism
thw00460  Cyanoamino acid metabolism
thw00470  D-Amino acid metabolism
thw00564  Glycerophospholipid metabolism
thw00600  Sphingolipid metabolism
thw00620  Pyruvate metabolism
thw00630  Glyoxylate and dicarboxylate metabolism
thw00640  Propanoate metabolism
thw00680  Methane metabolism
thw00860  Porphyrin metabolism
thw00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system