KEGG   PATHWAY: umr00520
Entry
umr00520                    Pathway                                
Name
Amino sugar and nucleotide sugar metabolism - Ursus maritimus (polar bear)
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
umr00520  Amino sugar and nucleotide sugar metabolism
umr00520

Module
umr_M00549  UDP-Glc biosynthesis, Glc => UDP-Glc [PATH:umr00520]
umr_M00554  UDP-Gal biosynthesis, Gal => UDP-Gal [PATH:umr00520]
umr_M00892  UDP-GlcNAc biosynthesis, eukaryotes, Fru-6P => UDP-GlcNAc [PATH:umr00520]
umr_M01000  GDP-Man biosynthesis, Fru-6P => GDP-Man [PATH:umr00520]
umr_M01001  GDP-L-Fuc biosynthesis, L-Fuc => GDP-L-Fuc [PATH:umr00520]
umr_M01003  UDP-GlcNAc biosynthesis, GlcNAc => UDP-GlcNAc [PATH:umr00520]
Other DBs
GO: 0006040 0009225
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103657436  PGM3; phosphoacetylglucosamine mutase [KO:K01836] [EC:5.4.2.3]
103657730  CHIT1; chitotriosidase-1 isoform X1 [KO:K01183] [EC:3.2.1.14]
103658240  UAP1; UDP-N-acetylhexosamine pyrophosphorylase isoform X1 [KO:K00972] [EC:2.7.7.23 2.7.7.83]
103662741  GMPPA; LOW QUALITY PROTEIN: mannose-1-phosphate guanyltransferase alpha [KO:K00966] [EC:2.7.7.13]
103663061  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
103663714  GNPDA1; glucosamine-6-phosphate isomerase 1 isoform X1 [KO:K02564] [EC:3.5.99.6]
103663867  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
103664456  HK3; hexokinase-3 isoform X1 [KO:K00844] [EC:2.7.1.1]
103665941  GALK1; LOW QUALITY PROTEIN: galactokinase [KO:K00849] [EC:2.7.1.6]
103666556  GALE; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
103667056  GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K00965] [EC:2.7.7.12]
103667783  HKDC1; hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
103668004  HK1; hexokinase-1 isoform X1 [KO:K00844] [EC:2.7.1.1]
103668581  PMM2; phosphomannomutase 2 isoform X1 [KO:K17497] [EC:5.4.2.8]
103668793  AMDHD2; N-acetylglucosamine-6-phosphate deacetylase isoform X1 [KO:K01443] [EC:3.5.1.25]
103670623  UXS1; UDP-glucuronic acid decarboxylase 1 isoform X1 [KO:K08678] [EC:4.1.1.35]
103671318  UGP2; UTP--glucose-1-phosphate uridylyltransferase isoform X1 [KO:K00963] [EC:2.7.7.9]
103671380  NAGK; N-acetyl-D-glucosamine kinase [KO:K00884] [EC:2.7.1.59]
103671429  HK2; hexokinase-2 [KO:K00844] [EC:2.7.1.1]
103671806  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
103672656  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
103672682  UGDH; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
103672697  GNPDA2; glucosamine-6-phosphate isomerase 2 [KO:K02564] [EC:3.5.99.6]
103672949  GNPNAT1; glucosamine 6-phosphate N-acetyltransferase [KO:K00621] [EC:2.3.1.4]
103673574  FCSK; L-fucose kinase [KO:K05305] [EC:2.7.1.52]
103674079  PMM1; phosphomannomutase 1 isoform X1 [KO:K17497] [EC:5.4.2.8]
103674684  GCK; hexokinase-4 isoform X1 [KO:K12407] [EC:2.7.1.2]
103675031  CHIA; LOW QUALITY PROTEIN: acidic mammalian chitinase [KO:K01183] [EC:3.2.1.14]
103675095  GMPPB; mannose-1-phosphate guanyltransferase beta [KO:K00966] [EC:2.7.7.13]
103675307  UAP1L1; UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 [KO:K00972] [EC:2.7.7.23 2.7.7.83]
103676726  GALK2; N-acetylgalactosamine kinase isoform X1 [KO:K18674] [EC:2.7.1.157]
103678471  GNE; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X1 [KO:K12409] [EC:3.2.1.183 2.7.1.60]
103678984  MPI; mannose-6-phosphate isomerase isoform X2 [KO:K01809] [EC:5.3.1.8]
103679139  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
103679636  GPI; glucose-6-phosphate isomerase isoform X1 [KO:K01810] [EC:5.3.1.9]
103679693  [KO:K01787] [EC:5.1.3.8]
103679991  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X1 [KO:K00820] [EC:2.6.1.16]
121099733  FPGT; fucose-1-phosphate guanylyltransferase [KO:K00976] [EC:2.7.7.30]
Compound
C00029  UDP-glucose
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00052  UDP-alpha-D-galactose
C00085  D-Fructose 6-phosphate
C00095  D-Fructose
C00096  GDP-mannose
C00103  D-Glucose 1-phosphate
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00167  UDP-glucuronate
C00181  D-Xylose
C00190  UDP-D-xylose
C00191  D-Glucuronate
C00203  UDP-N-acetyl-D-galactosamine
C00216  D-Arabinose
C00259  L-Arabinose
C00267  alpha-D-Glucose
C00275  D-Mannose 6-phosphate
C00325  GDP-L-fucose
C00329  D-Glucosamine
C00333  D-Galacturonate
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00394  GDP-glucose
C00446  alpha-D-Galactose 1-phosphate
C00461  Chitin
C00498  ADP-glucose
C00501  CDP-glucose
C00617  UDP-D-galacturonate
C00636  D-Mannose 1-phosphate
C00645  N-Acetyl-D-mannosamine
C00668  alpha-D-Glucose 6-phosphate
C00714  Pectin
C00734  Chitosan
C00842  dTDP-glucose
C00935  UDP-L-arabinose
C00976  GDP-D-mannuronate
C00984  alpha-D-Galactose
C01019  L-Fucose
C01050  UDP-N-acetylmuramate
C01132  N-Acetyl-D-galactosamine
C01170  UDP-N-acetyl-D-mannosamine
C01623  UDP-apiose
C01674  Chitobiose
C02262  D-Galactosamine
C02280  GDP-L-galactose
C02352  1,4-beta-D-Xylan
C02474  Arabinan
C02713  N-Acetylmuramate
C02985  L-Fucose 1-phosphate
C03733  UDP-alpha-D-galactofuranose
C03737  alpha-D-Xylose 1-phosphate
C03906  beta-L-Arabinose 1-phosphate
C04037  1-Phospho-alpha-D-galacturonate
C04257  N-Acetyl-D-mannosamine 6-phosphate
C04501  N-Acetyl-alpha-D-glucosamine 1-phosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385  D-Glucuronate 1-phosphate
C06023  D-Glucosaminide
C06156  alpha-D-Glucosamine 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11521  UDP-6-sulfoquinovose
C15925  GDP-L-gulose
C16183  alpha-D-Arabinopyranose 1-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C17269  GDP-D-arabinopyranose
C18060  N-Acetyl-alpha-D-galactosamine 1-phosphate
C18094  UDP-L-arabinofuranose
C19769  1,6-Anhydro-N-acetyl-beta-muramate
C21027  N-Acetylmuramic acid alpha-1-phosphate
C22029  alpha-D-Galactosamine 1-phosphate
Reference
PMID:2793832
  Authors
Wyk P, Reeves P
  Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
  Journal
J Bacteriol 171:5687-93 (1989)
DOI:10.1128/JB.171.10.5687-5693.1989
Reference
PMID:8071227
  Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
  Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
  Journal
J Bacteriol 176:5483-93 (1994)
DOI:10.1128/JB.176.17.5483-5493.1994
Reference
PMID:8444803
  Authors
Kessler AC, Haase A, Reeves PR
  Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
  Journal
J Bacteriol 175:1412-22 (1993)
DOI:10.1128/JB.175.5.1412-1422.1993
Reference
PMID:9811644
  Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
  Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
  Journal
J Bacteriol 180:5875-84 (1998)
DOI:10.1128/JB.180.22.5875-5884.1998
Reference
  Authors
Skurnik M, Peippo A, Ervela E
  Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
  Journal
Mol Microbiol 37:316-30 (2000)
DOI:10.1046/j.1365-2958.2000.01993.x
Reference
  Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
  Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
  Journal
Nature 406:959-64 (2000)
DOI:10.1038/35023079
Reference
  Authors
Ringenberg M, Lichtensteiger C, Vimr E
  Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
  Journal
Glycobiology 11:533-9 (2001)
DOI:10.1093/glycob/11.7.533
Reference
  Authors
McCoy AJ, Sandlin RC, Maurelli AT
  Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
  Journal
J Bacteriol 185:1218-28 (2003)
DOI:10.1128/JB.185.4.1218-1228.2003
Reference
  Authors
JACOBSON B, DAVIDSON EA
  Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
  Journal
J Biol Chem 237:638-42 (1962)
Reference
  Authors
Seifert GJ
  Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
  Journal
Curr Opin Plant Biol 7:277-84 (2004)
DOI:10.1016/j.pbi.2004.03.004
Reference
  Authors
Uehara T, Park JT
  Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
  Journal
J Bacteriol 186:7273-9 (2004)
DOI:10.1128/JB.186.21.7273-7279.2004
Reference
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
Reference
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
Reference
  Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
  Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
  Journal
Glycobiology 16:165-72 (2006)
DOI:10.1093/glycob/cwj050
Reference
  Authors
Campbell CT, Yarema KJ
  Title
Large-scale approaches for glycobiology.
  Journal
Genome Biol 6:236 (2005)
DOI:10.1186/gb-2005-6-11-236
Reference
  Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
  Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
  Journal
J Bacteriol 188:1660-2 (2006)
DOI:10.1128/JB.188.4.1660-1662.2006
Reference
  Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
  Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
  Journal
Plant J 48:286-95 (2006)
DOI:10.1111/j.1365-313X.2006.02872.x
Reference
  Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
  Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
  Journal
Plant Physiol 143:156-71 (2007)
DOI:10.1104/pp.106.090167
Reference
  Authors
Oka T, Nemoto T, Jigami Y
  Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
  Journal
J Biol Chem 282:5389-403 (2007)
DOI:10.1074/jbc.M610196200
Reference
  Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
  Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
  Journal
J Bacteriol 189:8727-36 (2007)
DOI:10.1128/JB.00793-07
Reference
  Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
  Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
  Journal
J Biol Chem 283:8125-35 (2008)
DOI:10.1074/jbc.M710078200
Reference
  Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
  Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
  Journal
J Biotechnol 134:33-45 (2008)
DOI:10.1016/j.jbiotec.2007.12.013
Reference
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Related
pathway
umr00010  Glycolysis / Gluconeogenesis
umr00040  Pentose and glucuronate interconversions
umr00051  Fructose and mannose metabolism
umr00052  Galactose metabolism
umr00053  Ascorbate and aldarate metabolism
umr00500  Starch and sucrose metabolism
umr00510  N-Glycan biosynthesis
umr00524  Neomycin, kanamycin and gentamicin biosynthesis
umr00541  Biosynthesis of various nucleotide sugars
KO pathway
ko00520   

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