KEGG   PATHWAY: vti00260
Entry
vti00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Vibrio tarriae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
vti00260  Glycine, serine and threonine metabolism
vti00260

Module
vti_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:vti00260]
vti_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:vti00260]
vti_M00621  Glycine cleavage system [PATH:vti00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Vibrio tarriae [GN:vti]
Gene
CEQ48_16135  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CEQ48_16995  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
CEQ48_07200  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
CEQ48_05620  metL; bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
CEQ48_08440  Aspartate-semialdehyde dehydrogenase 2 [KO:K00133] [EC:1.2.1.11]
CEQ48_08785  asd; Aspartate-semialdehyde dehydrogenase 1 [KO:K00133] [EC:1.2.1.11]
CEQ48_07205  homoserine kinase [KO:K00872] [EC:2.7.1.39]
CEQ48_07210  threonine synthase [KO:K01733] [EC:4.2.3.1]
CEQ48_04590  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CEQ48_14185  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CEQ48_01450  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CEQ48_16990  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CEQ48_06485  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
CEQ48_14940  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CEQ48_03665  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CEQ48_17355  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
CEQ48_06635  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CEQ48_00315  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CEQ48_12970  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CEQ48_07290  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CEQ48_03740  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
CEQ48_03745  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
CEQ48_01460  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
CEQ48_01435  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
CEQ48_05825  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CEQ48_06975  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CEQ48_01455  gcvH; glycine cleavage system protein H [KO:K02437]
CEQ48_17475  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
CEQ48_12225  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CEQ48_05020  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CEQ48_18785  ilvA; PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
CEQ48_12155  alr; alanine racemase [KO:K25317] [EC:5.1.1.10]
CEQ48_12920  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CEQ48_12915  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CEQ48_10945  aminotransferase class III [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
vti00010  Glycolysis / Gluconeogenesis
vti00020  Citrate cycle (TCA cycle)
vti00230  Purine metabolism
vti00250  Alanine, aspartate and glutamate metabolism
vti00270  Cysteine and methionine metabolism
vti00290  Valine, leucine and isoleucine biosynthesis
vti00300  Lysine biosynthesis
vti00330  Arginine and proline metabolism
vti00460  Cyanoamino acid metabolism
vti00470  D-Amino acid metabolism
vti00564  Glycerophospholipid metabolism
vti00600  Sphingolipid metabolism
vti00620  Pyruvate metabolism
vti00630  Glyoxylate and dicarboxylate metabolism
vti00640  Propanoate metabolism
vti00680  Methane metabolism
vti00860  Porphyrin metabolism
vti00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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