Cytoskeleton Proteins

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 Eukaryotic cytoskeleton proteins
   Actin filaments / Microfilaments
     Actins
       Actins
       Actin-related proteins
         K16575  ACTR1, ARP1; centractin
         K11662  ACTR6, ARP6; actin-related protein 6
         K16576  ACTR10, ARP11; actin-related protein 10
         K16615  PARP7; actin-related protein 7, plant
         K16616  PARP8; actin-related protein 8, plant
     Actin-binding proteins
       Myosins
       Arp2/3 complex
         K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
         K05758  ARPC2; actin related protein 2/3 complex, subunit 2
         K05756  ARPC3; actin related protein 2/3 complex, subunit 3
         K05755  ARPC4; actin related protein 2/3 complex, subunit 4
         K05754  ARPC5; actin related protein 2/3 complex, subunit 5
         K17260  ACTR2, ARP2; actin-related protein 2
         K18584  ACTR3, ARP3; actin-related protein 3
       WASP / WAVE
       Formins
       Profilin
       Thymosin
       ADF / Cofilin
       Gelsolin / villin
       Ezrin/Radixin/Moesin
       Capping proteins
       Tropomyosins
       Troponins
       Cross-linking proteins
       Others
         K18621  ANLN; actin-binding protein anillin
         K18622  ADD; adducin
         K12327  CALD1; caldesmon
         K28562  CNN; calponin
         K20526  TAGLN; transgelin
         K18623  COBL; protein cordon-bleu
         K06106  CTTN, EMS1; cortactin
         K16680  ED; echinoid
         K25094  EPB42; erythrocyte membrane protein band 4.2
         K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
         K05767  IQGAP2_3; Ras GTPase-activating-like protein IQGAP2/3
         K18624  MAEA, EMP; macrophage erythroblast attacher
         K06275  PARV; parvin
         K17275  PLS1; plastin-1
         K17276  LCP1, PLS2; plastin-2
         K17336  PLS3; plastin-3
         K17579  PPP1R42, LRRC67; protein phosphatase 1 regulatory subunit 42
         K18625  SHROOM; protein Shroom
         K05701  TJP1, ZO1; tight junction protein 1
         K12567  TTN; titin [EC:2.7.11.1]
         K19879  TCAP; telethonin
         K17478  FKBP15, WAFL; FK506-binding protein 15
         K06274  VASP; vasodilator-stimulated phosphoprotein
         K22030  LMOD; leiomodin
         K22031  MYZAP; myocardial zonula adherens protein
         K23026  LIMA1, EPLIN; LIM domain and actin-binding protein 1
         K23027  MYOC; myocilin
         K23028  SPECC1; cytospin
         K19199  SETD3; protein-histidine N-methyltransferase [EC:2.1.1.85]
         K23751  TRIOBP; TRIO and F-actin-binding protein
         K23917  POF1B; protein POF1B
         K23918  NEXN; nexilin
         K24144  NHS; Nance-Horan syndrome protein and NHS-like proteins
         K24165  PCARE; photoreceptor cilium actin regulator
         K24776  RUFY3; RUN and FYVE domain-containing protein 3
         K25865  NEBL; nebulette
         K26050  MYOZ; myozenin
         K26539  ACTMAP; actin maturation protease [EC:3.4.11.-]
         K25509  CRYBG; beta/gamma crystallin domain-containing protein
         K27698  FILIP1; filamin-A-interacting protein 1
         K27921  NAA80; N-alpha-acetyltransferase 80 [EC:2.3.1.-]
         K27922  ARPIN; arpin
         K28086  CRMP1, DPYSL1; dihydropyrimidinase-related protein 1
         K07528  DPYSL2, CRMP2; dihydropyrimidinase-related protein 2
         K28087  DPYSL3, CRMP4; dihydropyrimidinase-related protein 3
         K28088  DPYSL4, CRMP3; dihydropyrimidinase-related protein 4
         K07529  DPYSL5, CRAM; dihydropyrimidinase-related protein 5
         K28102  COTL1, COAA; coactosin
         K28168  FAM107A; actin-associated protein FAM107A
         K28488  DGCR6, GDL; protein DGCR6
         K28539  ECSCR; endothelial cell-specific chemotaxis regulator
         K28828  NCKIPSD, SPIN90; NCK-interacting protein with SH3 domain
         K28934  LURAP1; leucine rich adaptor protein 1
         K16307  CDC42BP; serine/threonine-protein kinase MRCK [EC:2.7.11.1]
         K26540  SCAB; stomatal closure-related actin-binding protein
         K28540  PLIM2; LIM domain-containing protein PLIM2
         K28541  WLIM; LIM domain-containing protein WLIM
   Intermediate filaments
   Microtubules
     Tubulins
     Tubulin-binding proteins
       Kinesins
       Stathmin
       Microtubule severing proteins
       EMAP
       Dyneins
         K10408  DNAH; dynein axonemal heavy chain
         K10409  DNAI1; dynein axonemal intermediate chain 1
         K11143  DNAI2; dynein axonemal intermediate chain 2
         K24722  DNAI3, WDR63; dynein axonemal intermediate chain 3
         K24723  DNAI4, WDR78; dynein axonemal intermediate chain 4
         K10410  DNALI; dynein axonemal light intermediate chain 1
         K10411  DNAL1; dynein axonemal light chain 1
         K10412  DNAL4; dynein axonemal light chain 4
         K10413  DYNC1H; dynein cytoplasmic 1 heavy chain
         K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
         K10415  DYNC1I, DNCI; dynein cytoplasmic 1 intermediate chain
         K10416  DYNC1LI, DNCLI; dynein cytoplasmic 1 light intermediate chain
         K10417  DYNC2LI; dynein cytoplasmic 2 light intermediate chain
         K10418  DYNLL; dynein light chain LC8-type
         K10419  DYNLRB, DNCL2; dynein light chain roadblock-type
         K10420  DYNLT1_3; dynein light chain Tctex-type 1/3
         K25419  DYNLT2, TCTE3; dynein light chain Tctex-type 2
         K25420  DYNLT4, TCTEX1D4; dynein light chain Tctex-type 4
         K25421  DYNLT5, TCTEX1D1; dynein light chain Tctex-type 5
         Dynein-related proteins
           K19750  DNAAF1, LRRC50, ODA7; dynein axonemal assembly factor 1
           K19751  DNAAF2, KTU, PF13; dynein axonemal assembly factor 2
           K19752  DNAAF3, PF22; dynein axonemal assembly factor 3
           K19758  DNAAF4, DYX1C1; dynein axonemal assembly factor 4
           K19759  DNAAF5; dynein axonemal assembly factor 5
           K24253  DNAAF6, PIH1D3; dynein axonemal assembly factor 6
           K24030  ZMYND10; zinc finger MYND domain-containing protein 10
           K25423  DNAAF8; dynein axonemal assembly factor 8
           K25424  DNAAF9; dynein axonemal assembly factor 9
           K24761  WDR92, DNAAF10; dynein axonemal assembly factor 10
           K19753  LRRC6, DNAAF11; dynein axonemal assembly factor 11
           K25425  LRRC56; leucine-rich repeat-containing protein 56
           K19870  SPAG1; sperm-associated antigen 1
           K25426  PIH1D1; PIH1 domain-containing protein 1
           K25427  PIH1D2; PIH1 domain-containing protein 2
           K19760  DAW1; dynein assembly factor with WDR repeat domains 1
           K19754  DRC1; dynein regulatry complex protein 1
       Dynactins
       Gamma-tubulin complex components
       XMAP215
       Cytoplasmic linker proteins (CLIPs)
       Fused toes protein (FTS)
       Hook proteins
       FTS and Hook-interacting proteins (FHIP)
       EB / APC
       Microtubule-associated proteins (MAPs)
         K10429  MAP1; microtubule-associated protein 1
         K10430  MAP2; microtubule-associated protein 2
         K10431  MAP4; microtubule-associated protein 4
         K10432  MAP6; microtubule-associated protein 6
         K10433  MAP7; microtubule-associated protein 7
         K10434  MAP9; microtubule-associated protein 9
         K28211  MAP10; microtubule-associated protein 10
         K24261  MAP11; microtubule-associated protein 11
         K10435  MAP1LC; microtubule-associated protein 1 light chain
         K04380  MAPT, TAU; microtubule-associated protein tau
         K19538  RP1; retinitis pigmentosa 1
         K16579  DCX; neuronal migration protein doublecortin
         K23029  EFHC1; EF-hand domain-containing protein 1
         K23919  NAV3; neuron navigator 3
         K25813  CCDC88B; coiled-coil domain-containing protein 88B
         K16732  PRC1, ASE1, MAP65; Ase1/PRC1/MAP65 family protein
         K28599  SYBU; syntabulin
         K28604  MTUS1; microtubule-associated tumor suppressor 1
         K28608  MTUS2; microtubule-associated tumor suppressor 2
         K28091  PCAP; plasma membrane-associated cation-binding protein
         K27854  MAP70; microtubule-associated protein 70
         K28092  RUK; protein RUNKEL
         K28093  TOR1; microtubule-associated protein TORTIFOLIA1 and related proteins
         K28094  MBP2C; microtubule binding protein 2C
         K28095  WVD2, WDL; protein WAVE-DAMPENED 2 and related proteins
         K28096  AIR9; microtubule-associated protein AIR9
         K28097  ICR, RIP; interactor of constitutive active ROPs
       Tubulin modification proteins
       Others
         K18628  TEKT1; tektin-1
         K18629  TEKT2; tektin-2
         K18630  TEKT3; tektin-3
         K18631  TEKT4; tektin-4
         K18632  TEKT5; tektin-5
         K17478  FKBP15, WAFL; FK506-binding protein 15
         K08798  MARK; MAP/microtubule affinity-regulating kinase [EC:2.7.11.1]
         K18633  MZT1, GIP1, GIP2; mitotic-spindle organizing protein 1
         K17579  PPP1R42, LRRC67; protein phosphatase 1 regulatory subunit 42
         K18634  SMRP1; spermatid-specific manchette-related protein 1
         K18635  SPR1; protein SPIRAL1 and related proteins
         K18636  TAN1; microtubule-binding protein TANGLED1
         K19755  RSPH1; radial spoke head protein 1
         K19756  RSPH4_6; radial spoke head protein 4/6
         K19757  RSPH9; radial spoke head protein 9
         K19827  MACF1; microtuble-actin crosslinking factor 1
         K06990  MEMO1; MEMO1 family protein
         K21387  AJAP1; adherens junction-associated protein 1
         K17292  TBCA; tubulin-specific chaperone A
         K17262  TBCB, CKAP1, ALF1; tubulin-specific chaperone B
         K21766  TBCC; tubulin-specific chaperone C
         K21767  TBCD; tubulin-specific chaperone D
         K21768  TBCE; tubulin-specific chaperone E
         K22449  TBCEL; tubulin-specific chaperone cofactor E-like protein
         K23845  KIFBP; KIF-binding protein
         K24203  MAP7D2; MAP7 domain-containing protein 2
         K24908  DIP2B; disco-interacting protein 2 homolog B
         K25762  NAT9; tubulin N-terminal N-acetyltransferase [EC:2.3.1.308]
         K26456  TANC; protein TANC
         K24345  KIC; calcium-binding protein KIC and related proteins
   Septins
     Septins
     Septin associated proteins
       K18637  AXL2; axial budding pattern protein 2
       K18638  BNI4; protein BNI4
       K02515  HSL1; serine/threonine-protein kinase HSL1, negative regulator of Swe1 kinase [EC:2.7.11.-]
       K18639  KCC4; serine/threonine-protein kinase KCC4 [EC:2.7.11.1]
       K06668  GIN4; serine/threonine-protein kinase GIN4 [EC:2.7.11.-]
       K04706  PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
       K12160  SUMO, SMT3; small ubiquitin-related modifier
 
 Prokaryotic cytoskeleton proteins
   Actin homologs
     Actins
       K03569  mreB; rod shape-determining protein MreB and related proteins
       K18640  parM, stbA; plasmid segregation protein ParM
       K18641  K18641; crenactin
     Actin-binding proteins
   Intermediate filaments homologs
   Microtubules homologs
   MinD / ParA class of bacterial cytoskeletal proteins

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Last updated: July 31, 2026