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ENTRY	nt06360
Name	Cushing syndrome
Category	Disease view; Endocrine and metabolic disease
Pathway	hsa04934 Cushing syndrome
Disease	H01431 Cushing syndrome
Display	drug-target relation   disease type

CRH-ACTH signaling N00324    CRH → CRHR → GNAS → ADCY → cAMP → PKA → CREB → ACTH N00325        RASD1* ⌿ GNAI ⌿ ADCY → cAMP → PKA → CREB → ACTH N00326            GNAS* → ADCY → cAMP → PKA → CREB → ACTH N00327    CRH → CRHR → GNAS → ADCY → cAMP → (PRKAR1A*+PRKACA) → CREB → ACTH   ACTH-cortisol signaling                             D1,D2  |     N00297    ACTH → (MC2R+MRAP) → GNAS → ADCY → cAMP → PKA → (NR5A1,NR4A1,SP1,P.. ⇒ (STAR,CYP11B1) → Cortisol                             D1,D2  |     N00321            GNAS* → ADCY → cAMP → PKA → (NR5A1,NR4A1,SP1,P.. ⇒ (STAR,CYP11B1) → Cortisol                             D1,D2  |     N00323                (PDE11A*,PDE8B*) ⌿ cAMP → (PRKAR1A+PRKACA) → (NR5A1,NR4A1,SP1,P.. ⇒ (STAR,CYP11B1) → Cortisol                             D1,D2  |     N00320                        PRKACA* → (NR5A1,NR4A1,SP1,P.. ⇒ (STAR,CYP11B1) → Cortisol                             D1,D2  |     N00322                        (PRKAR1A*+PRKACA) → (NR5A1,NR4A1,SP1,P.. ⇒ (STAR,CYP11B1) → Cortisol   EGFR-ERK-ACTH signaling N00318        EGFR → ERK1/2 → ACTH N00319    USP8* → EGFR → ERK1/2 → ACTH   Nuclear receptor signaling N00317    KA → (AHR+ARNT) ⇒ (IL6,IL22,PTGS2,VE.. N00315    AIP* ⌿ AHR N00290            (MEN1*+KMT2A) ⌿ (CDKN1B,CDKN2C) N00316                CDKN1B* ⌿ (CCNE+CDK2) → RB1 ⌿ E2F

		Drug name
D1	D00410	Metyrapone (JP18/USP/INN)
D2	D10950	Levoketoconazole (USAN/INN)