KEGG   Homo sapiens (human): 2516
Entry
2516              CDS       T01001                                 
Symbol
NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXX4, SRXY3, hSF-1
Name
(RefSeq) nuclear receptor subfamily 5 group A member 1
  KO
K08560  steroidogenic factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
Network
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00306  SF-1-mediated transcription
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
Disease
H00598  46,XX testicular disorder of sex development
H00607  46,XY gonadal dysgenesis
H00627  Premature ovarian failure
H01282  Spermatogenic failure
H02316  Adrenal insufficiency, NR5A1 related
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    2516 (NR5A1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    2516 (NR5A1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    2516 (NR5A1)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    2516 (NR5A1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 Fushi tarazu-F1-like
    2516 (NR5A1)
Nuclear receptors [BR:hsa03310]
 5. Fushi tarazu-F1 like
  5A. Fushi tarazu-F1 like receptor
   2516 (NR5A1)
SSDB
Motif
Pfam: zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 2516
NCBI-ProteinID: NP_004950
OMIM: 184757
HGNC: 7983
Ensembl: ENSG00000136931
UniProt: Q13285 F1D8R8
Structure
LinkDB
Position
9:complement(124481236..124507399)
AA seq 461 aa
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKT
QRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKL
ETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPL
AGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQV
RARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQN
CWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLA
LQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLL
LCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
NT seq 1386 nt   +upstreamnt  +downstreamnt
atggactattcgtacgacgaggacctggacgagctgtgccccgtgtgcggggacaaggtg
tccggctaccactacggactgctcacgtgtgagagctgcaagggcttcttcaagcgcacg
gtgcagaacaacaagcactacacgtgcaccgagagccagagctgcaagatcgacaagacg
cagcgcaagcgctgtcccttctgccgcttccagaaatgcctgacggtggggatgcgcctg
gaagccgtgcgcgctgaccgtatgaggggtggccggaacaagtttgggccgatgtacaag
cgggaccgggccctgaaacagcagaagaaggcacagattcgggccaatggcttcaagctg
gagacagggcccccgatgggggtgcccccgccgccccctcccgcaccggactacgtgctg
cctcccagcctgcatgggcctgagcccaagggcctggccgccggtccacctgctgggcca
ctgggcgactttggggccccagcactgcccatggccgtgcccggtgcccacgggccactg
gctggctacctctaccctgcctttcctggccgtgccatcaagtctgagtacccggagcct
tatgccagccccccacagcctgggctgccgtacggctacccagagcccttctctggaggg
cccaacgtgcctgagctcatcctgcagctgctgcagctggagccggatgaggaccaggtg
cgggcccgcatcttgggctgcctgcaggagcccaccaaaagccgccccgaccagccggcg
gccttcggcctcctgtgcagaatggccgaccagaccttcatctccatcgtggactgggca
cgcaggtgcatggtcttcaaggagctggaggtggccgaccagatgacgctgctgcagaac
tgctggagcgagctgctggtgttcgaccacatctaccgccaggtccagcacggcaaggag
ggcagcatcctgctggtcaccgggcaggaggtggagctgaccacagtggccacccaggcg
ggctcgctgctgcacagcctggtgttgcgggcgcaggagctggtgctgcagctgcttgcg
ctgcagctggaccggcaggagtttgtctgcctcaagttcatcatcctcttcagcctggat
ttgaagttcctgaataaccacatcctggtgaaagacgctcaggagaaggccaacgccgcc
ctgcttgactacaccctgtgccactacccgcactgcggggacaaattccagcagctgctg
ctgtgcctggtggaggtgcgggccctgagcatgcaggccaaggagtacctgtaccacaag
cacctgggcaacgagatgccccgcaacaacctgctcatcgaaatgctgcaagccaagcag
acttga

KEGG   Homo sapiens (human): 3164
Entry
3164              CDS       T01001                                 
Symbol
NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
Name
(RefSeq) nuclear receptor subfamily 4 group A member 1
  KO
K04465  nuclear receptor subfamily 4 group A member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
Network
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3164 (NR4A1)
   04151 PI3K-Akt signaling pathway
    3164 (NR4A1)
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    3164 (NR4A1)
   04927 Cortisol synthesis and secretion
    3164 (NR4A1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    3164 (NR4A1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    3164 (NR4A1)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    3164 (NR4A1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 nerve growth factor IB-like
    3164 (NR4A1)
Nuclear receptors [BR:hsa03310]
 4. Nerve growth factor IB like
  4A. Nerve growth factor IB like receptor
   3164 (NR4A1)
SSDB
Motif
Pfam: zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 3164
NCBI-ProteinID: NP_002126
OMIM: 139139
HGNC: 7980
Ensembl: ENSG00000123358
UniProt: P22736
Structure
LinkDB
Position
12:52022832..52059503
AA seq 598 aa
MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV
DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA
SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK
YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS
PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG
DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA
AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
NT seq 1797 nt   +upstreamnt  +downstreamnt
atgccctgtatccaagcccaatatgggacaccagcaccgagtccgggaccccgtgaccac
ctggcaagcgaccccctgacccctgagttcatcaagcccaccatggacctggccagcccc
gaggcagcccccgctgcccccactgccctgcccagcttcagcaccttcatggacggctac
acaggagagtttgacaccttcctctaccagctgccaggaacagtccagccatgctcctca
gcctcctcctcggcctcctccacatcctcgtcctcagccacctcccctgcctctgcctcc
ttcaagttcgaggacttccaggtgtacggctgctaccccggccccctgagcggcccagtg
gatgaggccctgtcctccagtggctctgactactatggcagcccctgctcggccccgtcg
ccctccacgcccagcttccagccgccccagctctctccctgggatggctccttcggccac
ttctcgcccagccagacttacgaaggcctgcgggcatggacagagcagctgcccaaagcc
tctgggcccccacagcctccagccttcttttccttcagtcctcccaccggccccagcccc
agcctggcccagagccccctgaagttgttcccctcacaggccacccaccagctgggggag
ggagagagctattccatgcctacggccttcccaggtttggcacccacttctccacacctt
gagggctcggggatactggatacacccgtgacctcaaccaaggcccggagcggggcccca
ggtggaagtgaaggccgctgtgctgtgtgtggggacaacgcttcatgccagcattatggt
gtccgcacatgtgagggctgcaagggcttcttcaagcgcacagtgcagaaaaacgccaag
tacatctgcctggctaacaaggactgccctgtggacaagaggcggcgaaaccgctgccag
ttctgccgcttccagaagtgcctggcggtgggcatggtgaaggaagttgtccgaacagac
agcctgaaggggcggcggggccggctaccttcaaaacccaagcagcccccagatgcctcc
cctgccaatctcctcacttccctggtccgtgcacacctggactcagggcccagcactgcc
aaactggactactccaagttccaggagctggtgctgccccactttgggaaggaagatgct
ggggatgtacagcagttctacgacctgctctccggttctctggaggtcatccgcaagtgg
gcggagaagatccctggctttgctgagctgtcaccggctgaccaggacctgttgctggag
tcggccttcctggagctcttcatcctccgcctggcgtacaggtctaagccaggcgagggc
aagctcatcttctgctcaggcctggtgctacaccggctgcagtgtgcccgtggcttcggg
gactggattgacagtatcctggccttctcaaggtccctgcacagcttgcttgtcgatgtc
cctgccttcgcctgcctctctgcccttgtcctcatcaccgaccggcatgggctgcaggag
ccgcggcgggtggaggagctgcagaaccgcatcgccagctgcctgaaggagcacgtggca
gctgtggcgggcgagccccagccagccagctgcctgtcacgtctgttgggcaaactgccc
gagctgcggaccctgtgcacccagggcctgcagcgcatcttctacctcaagctggaggac
ttggtgccccctccacccatcattgacaagatcttcatggacacgctgcccttctga

KEGG   Homo sapiens (human): 6667
Entry
6667              CDS       T01001                                 
Symbol
SP1
Name
(RefSeq) Sp1 transcription factor
  KO
K04684  transcription factor Sp1
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04137  Mitophagy - animal
hsa04350  TGF-beta signaling pathway
hsa04915  Estrogen signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05163  Human cytomegalovirus infection
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05224  Breast cancer
hsa05231  Choline metabolism in cancer
hsa05415  Diabetic cardiomyopathy
Network
nt06240  Transcription (cancer)
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00132  Amplified MYCN to transcriptional repression
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
Drug target
Terameprocol: D09014
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    6667 (SP1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    6667 (SP1)
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    6667 (SP1)
   04928 Parathyroid hormone synthesis, secretion and action
    6667 (SP1)
   04927 Cortisol synthesis and secretion
    6667 (SP1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6667 (SP1)
   05202 Transcriptional misregulation in cancer
    6667 (SP1)
   05231 Choline metabolism in cancer
    6667 (SP1)
  09162 Cancer: specific types
   05224 Breast cancer
    6667 (SP1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    6667 (SP1)
  09164 Neurodegenerative disease
   05016 Huntington disease
    6667 (SP1)
   05017 Spinocerebellar ataxia
    6667 (SP1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    6667 (SP1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    6667 (SP1)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    6667 (SP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6667 (SP1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    6667 (SP1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 SP/KLF family and related proteins
    6667 (SP1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    6667 (SP1)
SSDB
Motif
Pfam: zf-C2H2 zf-H2C2_2 zf-C2H2_4 Zap1_zf1 zf-C2H2_6 zf-C2H2_8
Other DBs
NCBI-GeneID: 6667
NCBI-ProteinID: NP_612482
OMIM: 189906
HGNC: 11205
Ensembl: ENSG00000185591
UniProt: P08047
Structure
LinkDB
Position
12:53380176..53416446
AA seq 785 aa
MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSP
LALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTS
KEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQ
TVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQG
LANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVT
SGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVS
GLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPL
SGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQ
TITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS
GIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTR
REACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTW
SYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALS
VGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINI
SGNGF
NT seq 2358 nt   +upstreamnt  +downstreamnt
atgagcgaccaagatcactccatggatgaaatgacagctgtggtgaaaattgaaaaagga
gttggtggcaataatgggggcaatggtaatggtggtggtgccttttcacaggctcgaagt
agcagcacaggcagtagcagcagcactggaggaggagggcaggagtcccagccatcccct
ttggctctgctggcagcaacttgcagcagaattgagtcacccaatgagaacagcaacaac
tcccagggcccgagtcagtcagggggaacaggtgagcttgacctcacagccacacaactt
tcacagggtgccaatggctggcagatcatctcttcctcctctggggctacccctacctca
aaggaacagagtggcagcagtaccaatggcagcaatggcagtgagtcttccaagaatcgc
acagtctctggtgggcagtatgttgtggctgccgctcccaacttacagaaccagcaagtt
ctgacaggactacctggagtgatgcctaatattcagtatcaagtaatcccacagttccag
accgttgatgggcaacagctgcagtttgctgccactggggcccaagtgcagcaggatggt
tctggtcaaatacagatcataccaggtgcaaaccaacagattatcacaaatcgaggaagt
ggaggcaacatcattgctgctatgccaaacctactccagcaggctgtccccctccaaggc
ctggctaataatgtactctcaggacagactcagtatgtgaccaatgtaccagtggccctg
aatgggaacatcaccttgctacctgtcaacagcgtttctgcagctaccttgactcccagc
tctcaggcagtcacgatcagcagctctgggtcccaggagagtggctcacagcctgtcacc
tcagggactaccatcagttctgccagcttggtatcatcacaagccagttccagctccttt
ttcaccaatgccaatagctactcaactactactaccaccagcaacatgggaattatgaac
tttactaccagtggatcatcagggaccaactctcaaggccagacaccccagagggtcagt
gggctacaggggtctgatgctctgaacatccagcaaaaccagacatctggaggctcattg
caagcaggccagcaaaaagaaggagagcaaaaccagcagacacagcagcaacaaattctt
atccagcctcagctagttcaagggggacaggccctccaggccctccaagcagcaccattg
tcagggcagacctttacaactcaagccatctcccaggaaaccctccagaacctccagctt
caggctgttccaaactctggtcccatcatcatccggacaccaacagtggggcccaatgga
caggtcagttggcagactctacagctgcagaacctccaagttcagaacccacaagcccaa
acaatcaccttagccccaatgcagggtgtttccttggggcagaccagcagcagcaacacc
actctcacacccattgcctcagctgcttccattcctgctggcacagtcactgtgaatgct
gctcaactctcctccatgccaggcctccagaccattaacctcagtgcattgggtacttca
ggaatccaggtgcacccaattcaaggcctgccgttggctatagcaaatgccccaggtgat
catggagctcagcttggtctccatggggctggtggtgatggaatacatgatgacacagca
ggtggagaggaaggagaaaacagcccagatgcccaaccccaagccggtcggaggacccgg
cgggaagcatgcacctgcccctactgtaaagacagtgaaggaaggggctcgggggatcct
ggcaaaaagaaacagcatatttgccacatccaaggctgtgggaaagtgtatggcaagacc
tctcacctgcgggcacacttgcgctggcatacaggcgagaggccatttatgtgtacctgg
tcatactgtgggaaacgcttcacacgttcggatgagctacagaggcacaaacgtacacac
acaggtgagaagaaatttgcctgccctgagtgtcctaagcgcttcatgaggagtgaccac
ctgtcaaaacatatcaagacccaccagaataagaagggaggcccaggtgtagctctgagt
gtgggcactttgcccctggacagtggggcaggttcagaaggcagtggcactgccactcct
tcagcccttattaccaccaatatggtagccatggaggccatctgtccagagggcattgcc
cgtcttgccaacagtggcatcaacgtcatgcaggtggcagatctgcagtccattaatatc
agtggcaatggcttctga

KEGG   Homo sapiens (human): 5087
Entry
5087              CDS       T01001                                 
Symbol
PBX1, CAKUHED
Name
(RefSeq) PBX homeobox 1
  KO
K09355  pre-B-cell leukemia transcription factor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04148  Efferocytosis
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
hsa05202  Transcriptional misregulation in cancer
Network
nt06240  Transcription (cancer)
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
nt06535  Efferocytosis
  Element
N00117  E2A-PBX1 fusion to transcriptional activation
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N01778  Production of IL10 via the Sirtuin1 signaling cascade
Disease
H00001  B-cell acute lymphoblastic leukemia
H01867  Congenital anomalies of kidney and urinary tract
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    5087 (PBX1)
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    5087 (PBX1)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    5087 (PBX1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    5087 (PBX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5087 (PBX1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Homeo domain TALE
    5087 (PBX1)
SSDB
Motif
Pfam: PBC Homeobox_KN Homeodomain YdaS_toxin HTH_3 UCH LZ3wCH EF-hand_2
Other DBs
NCBI-GeneID: 5087
NCBI-ProteinID: NP_002576
OMIM: 176310
HGNC: 8632
Ensembl: ENSG00000185630
UniProt: P40424 A8K5V0
Structure
LinkDB
Position
1:164559184..164886047
AA seq 430 aa
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE
AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP
EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM
NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF
NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE
EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG
AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG
PGSVHSDTSN
NT seq 1293 nt   +upstreamnt  +downstreamnt
atggacgagcagcccaggctgatgcattcccatgctggggtcgggatggccggacacccc
ggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaag
caggacattggagacattttacagcaaattatgaccatcacagaccagagtttggatgag
gcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtg
ttgtgtgaaatcaaagaaaaaacagttttgagtatccgaggagcccaggaggaggaaccc
acagacccccagctgatgcggctggacaacatgctgttagcggaaggcgtggcggggcct
gagaagggcggagggtcggcggcagcggcggcagcggcggcggcttctggaggggcaggt
tcagacaactcagtggagcattcagattacagagccaaactctcacagatcagacaaatc
taccatacggagctggagaaatacgagcaggcctgcaacgagttcaccacccacgtgatg
aatctcctgcgagagcaaagccggaccaggcccatctccccaaaggagattgagcggatg
gtcagcatcatccaccgcaagttcagctccatccagatgcagctcaagcagagcacgtgc
gaggcggtgatgatcctgcgttcccgatttctggatgcgcggcggaagagacggaatttc
aacaagcaagcgacagaaatcctgaatgaatatttctattcccatctcagcaacccttac
cccagtgaggaagccaaagaggagttagccaagaagtgtggcatcacagtctcccaggta
tcaaactggtttggaaataagcgaatccggtacaagaagaacataggtaaatttcaagag
gaagccaatatttatgctgccaaaacagctgtcactgctaccaatgtgtcagcccatgga
agccaagctaactcgccctcaactcccaactcggctggttcttccagttcttttaacatg
tcaaactctggagatttgttcatgagcgtgcagtcactcaatggggattcttaccaaggg
gcccaggttggagccaacgtgcaatcacaggtggatacccttcgccatgttatcagccag
acaggaggatacagtgatggactcgcagccagtcagatgtacagtccgcagggcatcagt
gctaatggaggttggcaggatgctactaccccttcatcagtgacctcccctacagaaggc
cctggcagtgttcactctgatacctccaactga

KEGG   Homo sapiens (human): 10488
Entry
10488             CDS       T01001                                 
Symbol
CREB3, LUMAN, LZIP, sLZIP
Name
(RefSeq) cAMP responsive element binding protein 3
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00510  HTLV-1 Tax to CREB-mediated transcription
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    10488 (CREB3)
   04024 cAMP signaling pathway
    10488 (CREB3)
   04022 cGMP-PKG signaling pathway
    10488 (CREB3)
   04151 PI3K-Akt signaling pathway
    10488 (CREB3)
   04152 AMPK signaling pathway
    10488 (CREB3)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    10488 (CREB3)
   04922 Glucagon signaling pathway
    10488 (CREB3)
   04915 Estrogen signaling pathway
    10488 (CREB3)
   04926 Relaxin signaling pathway
    10488 (CREB3)
   04935 Growth hormone synthesis, secretion and action
    10488 (CREB3)
   04918 Thyroid hormone synthesis
    10488 (CREB3)
   04928 Parathyroid hormone synthesis, secretion and action
    10488 (CREB3)
   04916 Melanogenesis
    10488 (CREB3)
   04925 Aldosterone synthesis and secretion
    10488 (CREB3)
   04927 Cortisol synthesis and secretion
    10488 (CREB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    10488 (CREB3)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    10488 (CREB3)
  09156 Nervous system
   04725 Cholinergic synapse
    10488 (CREB3)
   04728 Dopaminergic synapse
    10488 (CREB3)
  09149 Aging
   04211 Longevity regulating pathway
    10488 (CREB3)
  09159 Environmental adaptation
   04714 Thermogenesis
    10488 (CREB3)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    10488 (CREB3)
   05203 Viral carcinogenesis
    10488 (CREB3)
  09162 Cancer: specific types
   05215 Prostate cancer
    10488 (CREB3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    10488 (CREB3)
   05161 Hepatitis B
    10488 (CREB3)
   05163 Human cytomegalovirus infection
    10488 (CREB3)
   05165 Human papillomavirus infection
    10488 (CREB3)
  09164 Neurodegenerative disease
   05016 Huntington disease
    10488 (CREB3)
   05020 Prion disease
    10488 (CREB3)
  09165 Substance dependence
   05030 Cocaine addiction
    10488 (CREB3)
   05031 Amphetamine addiction
    10488 (CREB3)
   05034 Alcoholism
    10488 (CREB3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    10488 (CREB3)
   04934 Cushing syndrome
    10488 (CREB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    10488 (CREB3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    10488 (CREB3)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf
Other DBs
NCBI-GeneID: 10488
NCBI-ProteinID: NP_006359
OMIM: 606443
HGNC: 2347
Ensembl: ENSG00000107175
UniProt: O43889
LinkDB
Position
9:35732666..35736999
AA seq 371 aa
MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSP
PASLNILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARL
VLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES
RVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISNKTSSSSTCILVLLVSFCL
LLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQLELPALQSEVPKDSTHQWLDGSDC
VLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEPLCRGPILPLQANLTRKGGWLPTGS
PSVILQDRYSG
NT seq 1116 nt   +upstreamnt  +downstreamnt
atggagctggaattggatgctggtgaccaagacctgctggccttcctgctagaggaaagt
ggagatttggggacggcacccgatgaggccgtgagggccccactggactgggcgctgccg
ctttctgaggtaccgagcgactgggaagtagatgatttgctgtgctccctgctgagtccc
ccagcgtcgttgaacattctcagctcctccaacccctgccttgtccaccatgaccacacc
tactccctcccacgggaaactgtctctatggatctagagagtgagagctgtagaaaagag
gggacccagatgactccacagcatatggaggagctggcagagcaggagattgctaggcta
gtactgacagatgaggagaagagtctattggagaaggaggggcttattctgcctgagaca
cttcctctcactaagacagaggaacaaattctgaaacgtgtgcggaggaagattcgaaat
aaaagatctgctcaagagagccgcaggaaaaagaaggtgtatgttgggggtttagagagc
agggtcttgaaatacacagcccagaatatggagcttcagaacaaagtacagcttctggag
gaacagaatttgtcccttctagatcaactgaggaaactccaggccatggtgattgagata
tcaaacaaaaccagcagcagcagcacctgcatcttggtcctactagtctccttctgcctc
ctccttgtacctgctatgtactcctctgacacaagggggagcctgccagctgagcatgga
gtgttgtcccgccagcttcgtgccctccccagtgaggacccttaccagctggagctgcct
gccctgcagtcagaagtgccgaaagacagcacacaccagtggttggacggctcagactgt
gtactccaggcccctggcaacacttcctgcctgctgcattacatgcctcaggctcccagt
gcagagcctcccctggagtggccattccctgacctcttctcagagcctctctgccgaggt
cccatcctccccctgcaggcaaatctcacaaggaagggaggatggcttcctactggtagc
ccctctgtcattttgcaggacagatactcaggctag

KEGG   Homo sapiens (human): 1385
Entry
1385              CDS       T01001                                 
Symbol
CREB1, CREB, CREB-1
Name
(RefSeq) cAMP responsive element binding protein 1
  KO
K05870  cyclic AMP-responsive element-binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04148  Efferocytosis
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04380  Osteoclast differentiation
hsa04612  Antigen processing and presentation
hsa04668  TNF signaling pathway
hsa04710  Circadian rhythm
hsa04713  Circadian entrainment
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
nt06535  Efferocytosis
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
N01773  PTGS2-PGE2-TGFB1 pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    1385 (CREB1)
   04024 cAMP signaling pathway
    1385 (CREB1)
   04022 cGMP-PKG signaling pathway
    1385 (CREB1)
   04151 PI3K-Akt signaling pathway
    1385 (CREB1)
   04152 AMPK signaling pathway
    1385 (CREB1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    1385 (CREB1)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1385 (CREB1)
  09152 Endocrine system
   04911 Insulin secretion
    1385 (CREB1)
   04922 Glucagon signaling pathway
    1385 (CREB1)
   04915 Estrogen signaling pathway
    1385 (CREB1)
   04926 Relaxin signaling pathway
    1385 (CREB1)
   04935 Growth hormone synthesis, secretion and action
    1385 (CREB1)
   04918 Thyroid hormone synthesis
    1385 (CREB1)
   04928 Parathyroid hormone synthesis, secretion and action
    1385 (CREB1)
   04916 Melanogenesis
    1385 (CREB1)
   04924 Renin secretion
    1385 (CREB1)
   04925 Aldosterone synthesis and secretion
    1385 (CREB1)
   04927 Cortisol synthesis and secretion
    1385 (CREB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    1385 (CREB1)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    1385 (CREB1)
  09156 Nervous system
   04725 Cholinergic synapse
    1385 (CREB1)
   04728 Dopaminergic synapse
    1385 (CREB1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    1385 (CREB1)
  09149 Aging
   04211 Longevity regulating pathway
    1385 (CREB1)
  09159 Environmental adaptation
   04710 Circadian rhythm
    1385 (CREB1)
   04713 Circadian entrainment
    1385 (CREB1)
   04714 Thermogenesis
    1385 (CREB1)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1385 (CREB1)
   05203 Viral carcinogenesis
    1385 (CREB1)
  09162 Cancer: specific types
   05215 Prostate cancer
    1385 (CREB1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1385 (CREB1)
   05161 Hepatitis B
    1385 (CREB1)
   05163 Human cytomegalovirus infection
    1385 (CREB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1385 (CREB1)
   05165 Human papillomavirus infection
    1385 (CREB1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1385 (CREB1)
  09164 Neurodegenerative disease
   05016 Huntington disease
    1385 (CREB1)
   05020 Prion disease
    1385 (CREB1)
  09165 Substance dependence
   05030 Cocaine addiction
    1385 (CREB1)
   05031 Amphetamine addiction
    1385 (CREB1)
   05034 Alcoholism
    1385 (CREB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    1385 (CREB1)
   04934 Cushing syndrome
    1385 (CREB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1385 (CREB1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    1385 (CREB1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    1385 (CREB1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    1385 (CREB1)
SSDB
Motif
Pfam: pKID bZIP_1 bZIP_2 bZIP_Maf ASD2
Other DBs
NCBI-GeneID: 1385
NCBI-ProteinID: NP_004370
OMIM: 123810
HGNC: 2345
Ensembl: ENSG00000118260
UniProt: P16220 Q53X93
Structure
LinkDB
Position
2:207529962..207605988
AA seq 327 aa
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY
RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA
NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI
RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR
VAVLENQNKTLIEELKALKDLYCHKSD
NT seq 984 nt   +upstreamnt  +downstreamnt
atgaccatggaatctggagccgagaaccagcagagtggagatgcagctgtaacagaagct
gaaaaccaacaaatgacagttcaagcccagccacagattgccacattagcccaggtatct
atgccagcagctcatgcaacatcatctgctcccaccgtaactctagtacagctgcccaat
gggcagacagttcaagtccatggagtcattcaggcggcccagccatcagttattcagtct
ccacaagtccaaacagttcagatttcaactattgcagaaagtgaagattcacaggagtca
gtggatagtgtaactgattcccaaaagcgaagggaaattctttcaaggaggccttcctac
aggaaaattttgaatgacttatcttctgatgcaccaggagtgccaaggattgaagaagag
aagtctgaagaggagacttcagcacctgccatcaccactgtaacggtgccaactccaatt
taccaaactagcagtggacagtatattgccattacccagggaggagcaatacagctggct
aacaatggtaccgatggggtacagggcctgcaaacattaaccatgaccaatgcagcagcc
actcagccgggtactaccattctacagtatgcacagaccactgatggacagcagatctta
gtgcccagcaaccaagttgttgttcaagctgcctctggagacgtacaaacataccagatt
cgcacagcacccactagcactattgcccctggagttgttatggcatcctccccagcactt
cctacacagcctgctgaagaagcagcacgaaagagagaggtccgtctaatgaagaacagg
gaagcagctcgagagtgtcgtagaaagaagaaagaatatgtgaaatgtttagaaaacaga
gtggcagtgcttgaaaatcaaaacaagacattgattgaggagctaaaagcacttaaggac
ctttactgccacaaatcagattaa

KEGG   Homo sapiens (human): 1386
Entry
1386              CDS       T01001                                 
Symbol
ATF2, CRE-BP1, CREB-2, CREB2, HB16, TREB7
Name
(RefSeq) activating transcription factor 2
  KO
K04450  cyclic AMP-dependent transcription factor ATF-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    1386 (ATF2)
   04668 TNF signaling pathway
    1386 (ATF2)
   04022 cGMP-PKG signaling pathway
    1386 (ATF2)
   04151 PI3K-Akt signaling pathway
    1386 (ATF2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    1386 (ATF2)
   04922 Glucagon signaling pathway
    1386 (ATF2)
   04915 Estrogen signaling pathway
    1386 (ATF2)
   04926 Relaxin signaling pathway
    1386 (ATF2)
   04935 Growth hormone synthesis, secretion and action
    1386 (ATF2)
   04918 Thyroid hormone synthesis
    1386 (ATF2)
   04928 Parathyroid hormone synthesis, secretion and action
    1386 (ATF2)
   04925 Aldosterone synthesis and secretion
    1386 (ATF2)
   04927 Cortisol synthesis and secretion
    1386 (ATF2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    1386 (ATF2)
  09156 Nervous system
   04728 Dopaminergic synapse
    1386 (ATF2)
  09149 Aging
   04211 Longevity regulating pathway
    1386 (ATF2)
  09159 Environmental adaptation
   04714 Thermogenesis
    1386 (ATF2)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1386 (ATF2)
   05203 Viral carcinogenesis
    1386 (ATF2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1386 (ATF2)
   05161 Hepatitis B
    1386 (ATF2)
   05163 Human cytomegalovirus infection
    1386 (ATF2)
  09164 Neurodegenerative disease
   05020 Prion disease
    1386 (ATF2)
  09165 Substance dependence
   05030 Cocaine addiction
    1386 (ATF2)
   05031 Amphetamine addiction
    1386 (ATF2)
   05034 Alcoholism
    1386 (ATF2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1386 (ATF2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1386 (ATF2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    1386 (ATF2)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf zf-C2H2 Herpes_UL16
Other DBs
NCBI-GeneID: 1386
NCBI-ProteinID: NP_001243019
OMIM: 123811
HGNC: 784
Ensembl: ENSG00000115966
UniProt: P15336
Structure
LinkDB
Position
2:complement(175072259..175168203)
AA seq 505 aa
MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARN
DSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIR
SKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD
SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNV
HVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGS
GLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE
RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPV
TAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQM
ADQSTEPALSQIVMAPSSQSQPSGS
NT seq 1518 nt   +upstreamnt  +downstreamnt
atgaaattcaagttacatgtgaattctgccaggcaatacaaggacctgtggaatatgagt
gatgacaaaccctttctatgtactgcgcctggatgtggccagcgttttaccaacgaggat
catttggctgtccataaacataaacatgagatgacactgaaatttggtccagcacgtaat
gacagtgtcattgtggctgatcagaccccaacaccaacaagattcttgaaaaactgtgaa
gaagtgggtttgtttaatgagttggcgagtccatttgagaatgaattcaagaaagcttca
gaagatgacattaaaaaaatgcctctagatttatcccctcttgcaacacctatcataaga
agcaaaattgaggagccttctgttgtagaaacaactcaccaggatagtcctttacctcac
ccagagtctactaccagtgatgagaaggaagtaccattggcacaaactgcacagcccaca
tcagctattgttcgtccagcatcattacaggttcccaatgtgctgcttacaagttctgac
tcaagtgtaattattcagcaggcagtaccttcaccaacctcaagtactgtaatcacccag
gcaccatcctctaacaggccaattgtccctgtaccaggcccatttcctcttctgttacat
cttcctaatggacaaaccatgcctgttgctattcctgcatcaattacaagttctaatgtg
catgttccagctgcagtcccactcgttcgaccagtcaccatggtgcctagtgttccagga
atcccaggtccttcctctccccaaccagtacagtcagaagcaaaaatgagattaaaagct
gctttgacccagcaacatcctccagttaccaatggtgatactgtcaaaggtcatggtagc
ggattggttaggactcagtcagaggaatctcgaccgcagtcattacaacagccagccaca
tccactacagaaactccggcttctccagctcacacaactccacagacccaaagtacaagt
ggtcgtcggagaagagcagctaacgaagatcctgatgaaaaaaggagaaagtttttagag
cgaaatagagcagcagcttcaagatgccgacaaaaaaggaaagtctgggttcagtcttta
gagaagaaagctgaagacttgagttcattaaatggtcagctgcagagtgaagtcaccctg
ctgagaaatgaagtggcacagctgaaacagcttcttctggctcataaagattgccctgta
accgccatgcagaagaaatctggctatcatactgctgataaagatgatagttcagaagac
atttcagtgccgagtagtccacatacagaagctatacagcatagttcggtcagcacatcc
aatggagtcagttcaacctccaaggcagaagctgtagccacttcagtcctcacccagatg
gcggaccagagtacagagcctgctctttcacagatcgttatggctccttcctcccagtca
cagccctcaggaagttga

KEGG   Homo sapiens (human): 1388
Entry
1388              CDS       T01001                                 
Symbol
ATF6B, ATF6beta, CREB-RP, CREBL1, G13
Name
(RefSeq) activating transcription factor 6 beta
  KO
K09049  cyclic AMP-dependent transcription factor ATF-6 beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04141  Protein processing in endoplasmic reticulum
hsa04151  PI3K-Akt signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    1388 (ATF6B)
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    1388 (ATF6B)
   04022 cGMP-PKG signaling pathway
    1388 (ATF6B)
   04151 PI3K-Akt signaling pathway
    1388 (ATF6B)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    1388 (ATF6B)
   04915 Estrogen signaling pathway
    1388 (ATF6B)
   04926 Relaxin signaling pathway
    1388 (ATF6B)
   04935 Growth hormone synthesis, secretion and action
    1388 (ATF6B)
   04918 Thyroid hormone synthesis
    1388 (ATF6B)
   04928 Parathyroid hormone synthesis, secretion and action
    1388 (ATF6B)
   04925 Aldosterone synthesis and secretion
    1388 (ATF6B)
   04927 Cortisol synthesis and secretion
    1388 (ATF6B)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    1388 (ATF6B)
  09156 Nervous system
   04728 Dopaminergic synapse
    1388 (ATF6B)
  09149 Aging
   04211 Longevity regulating pathway
    1388 (ATF6B)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1388 (ATF6B)
   05203 Viral carcinogenesis
    1388 (ATF6B)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1388 (ATF6B)
   05161 Hepatitis B
    1388 (ATF6B)
   05163 Human cytomegalovirus infection
    1388 (ATF6B)
  09164 Neurodegenerative disease
   05020 Prion disease
    1388 (ATF6B)
  09165 Substance dependence
   05030 Cocaine addiction
    1388 (ATF6B)
   05031 Amphetamine addiction
    1388 (ATF6B)
   05034 Alcoholism
    1388 (ATF6B)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1388 (ATF6B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1388 (ATF6B)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    1388 (ATF6B)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 ZapB bZIP_Maf DUF4407 GIT_CC YabA Docking
Other DBs
NCBI-GeneID: 1388
NCBI-ProteinID: NP_004372
OMIM: 600984
HGNC: 2349
Ensembl: ENSG00000213676
UniProt: Q99941 Q6AZW6
LinkDB
Position
6:complement(32115264..32128246)
AA seq 703 aa
MAELMLLSEIADPTRFFTDNLLSPEDWGLQNSTLYSGLDEVAEEQTQLFRCPEQDVPFDG
SSLDVGMDVSPSEPPWELLPIFPDLQVKSEPSSPCSSSSLSSESSRLSTEPSSEALGVGE
VLHVKTESLAPPLCLLGDDPTSSFETVQINVIPTSDDSSDVQTKIEPVSPCSSVNSEASL
LSADSSSQAFIGEEVLEVKTESLSPSGCLLWDVPAPSLGAVQISMGPSLDGSSGKALPTR
KPPLQPKPVVLTTVPMPSRAVPPSTTVLLQSLVQPPPVSPVVLIQGAIRVQPEGPAPSLP
RPERKSIVPAPMPGNSCPPEVDAKLLKRQQRMIKNRESACQSRRKKKEYLQGLEARLQAV
LADNQQLRRENAALRRRLEALLAENSELKLGSGNRKVVCIMVFLLFIAFNFGPVSISEPP
SAPISPRMNKGEPQPRRHLLGFSEQEPVQGVEPLQGSSQGPKEPQPSPTDQPSFSNLTAF
PGGAKELLLRDLDQLFLSSDCRHFNRTESLRLADELSGWVQRHQRGRRKIPQRAQERQKS
QPRKKSPPVKAVPIQPPGPPERDSVGQLQLYRHPDRSQPAFLDAIDRREDTFYVVSFRRD
HLLLPAISHNKTSRPKMSLVMPAMAPNETLSGRGAPGDYEEMMQIECEVMDTRVIHIKTS
TVPPSLRKQPSPTPGNATGGPLPVSAASQAHQASHQPLYLNHP
NT seq 2112 nt   +upstreamnt  +downstreamnt
atggcggagctgatgctgctcagcgagattgctgacccgacgcgtttcttcaccgacaac
ctgcttagcccggaggactggggtctgcagaacagcaccttgtattctggcctagatgaa
gtggccgaggagcagacgcagctcttccgttgcccggagcaggatgtcccgtttgacggc
agctccctggacgtggggatggatgtcagcccctctgagcccccatgggaactcctgccg
atcttcccagatcttcaggtgaagtctgagccatcttccccctgctcttcctcctccctc
agctccgagtcatcgcgtctctccacagagccatccagcgaggctcttggggtaggggag
gtgctccatgtgaagacagagtccttggcacccccactgtgtctcctgggagatgaccca
acatcctcatttgaaaccgtccagatcaacgttatccccacctctgatgattcctcagat
gtccagaccaagatagaacctgtctctccatgttcttccgtcaactctgaggcctccctg
ctctcagccgactcctccagccaggcttttataggagaggaggtcctggaagtgaagaca
gagtccctgtccccttcaggatgcctcctgtgggatgtcccagccccctcacttggagct
gtccagatcagcatgggcccatcccttgatggctcctcaggcaaagccctgcccacccgg
aagccgccactgcagcccaaacctgtagtgctaaccactgtcccaatgccatccagagct
gtgcctcccagcaccacagtccttctgcagtccctcgtccagccacccccagtgtcccca
gttgtcctcatccagggtgctattcgagtccagcctgaagggccggctccctctctacca
cggcctgagaggaagagcatcgttcccgctcctatgcctggaaactcctgcccgcctgaa
gtggatgcaaagctgctgaagcggcagcagcgaatgatcaagaaccgggagtcagcctgc
cagtcccggagaaagaagaaagagtatctgcagggactggaggctcggctgcaagcagta
ctggctgacaaccagcagctccgccgagagaatgctgccctccggcggcggctggaggcc
ctgctggctgaaaacagcgagctcaagttagggtctggaaacaggaaggtggtctgcatc
atggtcttccttctcttcattgccttcaactttggacctgtcagcatcagtgagcctcct
tcagctcccatctctcctcggatgaacaagggggagcctcaaccccggagacacttgctg
gggttctcagagcaagagccagttcagggagttgaacctctccaggggtcctcccagggc
cctaaggagccccagcccagccccacagaccagcccagtttcagcaacctgacagccttc
cctgggggcgccaaggagctactactaagagacctagaccagctcttcctctcctctgat
tgccggcacttcaaccgcactgagtccctgaggcttgctgacgagttgagtggctgggtc
cagcgccaccagagaggccggaggaagatccctcagagggcccaggagagacagaagtct
cagccacggaagaagtcacctccagttaaggcagtccccatccaaccccctggaccccca
gaaagggattctgtgggccagctgcaactatatcgccacccagaccgttcgcagccagca
ttcttggatgcaattgaccgacgggaagacacattttatgttgtctctttccgaagggac
cacctgctgctcccagccatcagccacaacaagacctcccggcccaagatgtccctggtg
atgcctgccatggcccccaatgagaccctgtcaggccgtggggccccgggggactatgag
gagatgatgcagatcgagtgtgaggtcatggacaccagggtgattcacatcaagacctcc
acagtgcccccctcgctccgaaaacagccatccccaaccccaggcaatgccacaggtggc
cccttgccagtctctgcagccagccaggcccaccaggcctcccaccagcccctctacctc
aatcatccctga

KEGG   Homo sapiens (human): 148327
Entry
148327            CDS       T01001                                 
Symbol
CREB3L4, AIBZIP, ATCE1, CREB3, CREB4, JAL, hJAL
Name
(RefSeq) cAMP responsive element binding protein 3 like 4
  KO
K09048  cyclic AMP-responsive element-binding protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06461  Huntington disease
nt06465  Prion disease
nt06516  TNF signaling
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    148327 (CREB3L4)
   04024 cAMP signaling pathway
    148327 (CREB3L4)
   04022 cGMP-PKG signaling pathway
    148327 (CREB3L4)
   04151 PI3K-Akt signaling pathway
    148327 (CREB3L4)
   04152 AMPK signaling pathway
    148327 (CREB3L4)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    148327 (CREB3L4)
   04922 Glucagon signaling pathway
    148327 (CREB3L4)
   04915 Estrogen signaling pathway
    148327 (CREB3L4)
   04926 Relaxin signaling pathway
    148327 (CREB3L4)
   04935 Growth hormone synthesis, secretion and action
    148327 (CREB3L4)
   04918 Thyroid hormone synthesis
    148327 (CREB3L4)
   04928 Parathyroid hormone synthesis, secretion and action
    148327 (CREB3L4)
   04916 Melanogenesis
    148327 (CREB3L4)
   04925 Aldosterone synthesis and secretion
    148327 (CREB3L4)
   04927 Cortisol synthesis and secretion
    148327 (CREB3L4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    148327 (CREB3L4)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    148327 (CREB3L4)
  09156 Nervous system
   04725 Cholinergic synapse
    148327 (CREB3L4)
   04728 Dopaminergic synapse
    148327 (CREB3L4)
  09149 Aging
   04211 Longevity regulating pathway
    148327 (CREB3L4)
  09159 Environmental adaptation
   04714 Thermogenesis
    148327 (CREB3L4)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    148327 (CREB3L4)
   05203 Viral carcinogenesis
    148327 (CREB3L4)
  09162 Cancer: specific types
   05215 Prostate cancer
    148327 (CREB3L4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    148327 (CREB3L4)
   05161 Hepatitis B
    148327 (CREB3L4)
   05163 Human cytomegalovirus infection
    148327 (CREB3L4)
   05165 Human papillomavirus infection
    148327 (CREB3L4)
  09164 Neurodegenerative disease
   05016 Huntington disease
    148327 (CREB3L4)
   05020 Prion disease
    148327 (CREB3L4)
  09165 Substance dependence
   05030 Cocaine addiction
    148327 (CREB3L4)
   05031 Amphetamine addiction
    148327 (CREB3L4)
   05034 Alcoholism
    148327 (CREB3L4)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    148327 (CREB3L4)
   04934 Cushing syndrome
    148327 (CREB3L4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    148327 (CREB3L4)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    148327 (CREB3L4)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 bZIP_Maf ZapB OppC_N DUF4407 HAUS-augmin3 ATG16 KASH_CCD APG6_N DUF1664
Other DBs
NCBI-GeneID: 148327
NCBI-ProteinID: NP_001242907
OMIM: 607138
HGNC: 18854
Ensembl: ENSG00000143578
UniProt: Q8TEY5
LinkDB
Position
1:153967487..153974359
AA seq 395 aa
MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHCPPPEVPVTRLQEQGLQGWKSGGDRGCGL
QESEPEDFLKLFIDPNEVYCSEASPGSDSGISEDPCHPDSPPAPRATSSPMLYEVVYEAG
ALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPFDAHAHILPRAGTVAPVPCTT
LLPCQTLFLTDEEKRLLGQEGVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKE
YIDGLESRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLI
LLFSLALIILPSFSPFQSRPEAGSEDYQPHGVTSRNILTHKDVTENLETQVVESRLREPP
GAKDANGSTRTLLEKMGGKPRPSGRIRSVLHADEM
NT seq 1188 nt   +upstreamnt  +downstreamnt
atggatctcggaatccctgacctgctggacgcgtggctggagcccccagaggatatcttc
tcgacaggatccgtcctggagctgggactccactgcccccctccagaggttccggtaact
aggctacaggaacagggactgcaaggctggaagtccggtggggaccgtggctgtggcctt
caagagagtgagcctgaagatttcttgaagcttttcattgatcccaatgaggtgtactgc
tcagaagcatctcctggcagtgacagtggcatctctgaggacccctgccatccagacagt
ccccctgcccccagggcaaccagttctcctatgctctatgaggttgtctatgaggcaggg
gccctggagaggatgcagggggaaactgggccaaatgtaggccttatctccatccagcta
gatcagtggagcccagcatttatggtgcctgattcctgcatggtcagtgagctgcccttt
gatgctcatgcccacatcctgcccagagcaggcaccgtagccccagtgccctgtacaacc
ctgctgccctgtcaaaccctgttcctgaccgatgaggagaagcgtctgctggggcaggaa
ggggtttccctgccctctcacctgcccctcaccaaggcagaggagagggtcctcaagaag
gtcaggaggaaaatccgtaacaagcagtcagctcaggacagtcggcggcggaagaaggag
tacattgatgggctggagagcagggtggcagcctgttctgcacagaaccaagaattacag
aaaaaagtccaggagctggagaggcacaacatctccttggtagctcagctccgccagctg
cagacgctaattgctcaaacttccaacaaagctgcccagaccagcacttgtgttttgatt
cttcttttttccctggctctcatcatcctgcccagcttcagtccattccagagtcgacca
gaagctgggtctgaggattaccagcctcacggagtgacttccagaaatatcctgacccac
aaggacgtaacagaaaatctggagacccaagtggtagagtccagactgagggagccacct
ggagccaaggatgcaaatggctcaacaaggacactgcttgagaagatgggagggaagcca
agacccagtgggcgcatccggtccgtgctgcatgcagatgagatgtga

KEGG   Homo sapiens (human): 468
Entry
468               CDS       T01001                                 
Symbol
ATF4, CREB-2, CREB2, TAXREB67, TXREB
Name
(RefSeq) activating transcription factor 4
  KO
K04374  cyclic AMP-dependent transcription factor ATF-4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04137  Mitophagy - animal
hsa04141  Protein processing in endoplasmic reticulum
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04668  TNF signaling pathway
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04915  Estrogen signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04932  Non-alcoholic fatty liver disease
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Renin-angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06516  TNF signaling
nt06534  Unfolded protein response
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01009  PERK-ATF4 signaling pathway
N01010  Mutation-caused aberrant PSEN1 to PERK-ATF4 signaling pathway
N01035  Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway
N01149  Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway
N01198  Scrapie conformation PrPSc to PERK-ATF4 signaling pathway
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    468 (ATF4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    468 (ATF4)
   04668 TNF signaling pathway
    468 (ATF4)
   04022 cGMP-PKG signaling pathway
    468 (ATF4)
   04151 PI3K-Akt signaling pathway
    468 (ATF4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    468 (ATF4)
  09143 Cell growth and death
   04210 Apoptosis
    468 (ATF4)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    468 (ATF4)
   04922 Glucagon signaling pathway
    468 (ATF4)
   04912 GnRH signaling pathway
    468 (ATF4)
   04915 Estrogen signaling pathway
    468 (ATF4)
   04926 Relaxin signaling pathway
    468 (ATF4)
   04935 Growth hormone synthesis, secretion and action
    468 (ATF4)
   04918 Thyroid hormone synthesis
    468 (ATF4)
   04928 Parathyroid hormone synthesis, secretion and action
    468 (ATF4)
   04925 Aldosterone synthesis and secretion
    468 (ATF4)
   04927 Cortisol synthesis and secretion
    468 (ATF4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    468 (ATF4)
  09156 Nervous system
   04725 Cholinergic synapse
    468 (ATF4)
   04728 Dopaminergic synapse
    468 (ATF4)
   04720 Long-term potentiation
    468 (ATF4)
   04722 Neurotrophin signaling pathway
    468 (ATF4)
  09149 Aging
   04211 Longevity regulating pathway
    468 (ATF4)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    468 (ATF4)
   05203 Viral carcinogenesis
    468 (ATF4)
  09162 Cancer: specific types
   05215 Prostate cancer
    468 (ATF4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    468 (ATF4)
   05161 Hepatitis B
    468 (ATF4)
   05163 Human cytomegalovirus infection
    468 (ATF4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    468 (ATF4)
   05012 Parkinson disease
    468 (ATF4)
   05014 Amyotrophic lateral sclerosis
    468 (ATF4)
   05020 Prion disease
    468 (ATF4)
   05022 Pathways of neurodegeneration - multiple diseases
    468 (ATF4)
  09165 Substance dependence
   05030 Cocaine addiction
    468 (ATF4)
   05031 Amphetamine addiction
    468 (ATF4)
   05034 Alcoholism
    468 (ATF4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    468 (ATF4)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    468 (ATF4)
   04934 Cushing syndrome
    468 (ATF4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    468 (ATF4)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    468 (ATF4)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 DUF3450 DUF4407 DUF4192 Nop53 AAA_13 Laminin_II bZIP_Maf
Other DBs
NCBI-GeneID: 468
NCBI-ProteinID: NP_001666
OMIM: 604064
HGNC: 786
Ensembl: ENSG00000128272
UniProt: P18848
Structure
LinkDB
Position
22:39520559..39522686
AA seq 351 aa
MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE
WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC
DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL
ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG
SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR
AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP
NT seq 1056 nt   +upstreamnt  +downstreamnt
atgaccgaaatgagcttcctgagcagcgaggtgttggtgggggacttgatgtcccccttc
gaccagtcgggtttgggggctgaagaaagcctaggtctcttagatgattacctggaggtg
gccaagcacttcaaacctcatgggttctccagcgacaaggctaaggcgggctcctccgaa
tggctggctgtggatgggttggtcagtccctccaacaacagcaaggaggatgccttctcc
gggacagattggatgttggagaaaatggatttgaaggagttcgacttggatgccctgttg
ggtatagatgacctggaaaccatgccagatgaccttctgaccacgttggatgacacttgt
gatctctttgcccccctagtccaggagactaataagcagcccccccagacggtgaaccca
attggccatctcccagaaagtttaacaaaacccgaccaggttgcccccttcaccttctta
caacctcttcccctttccccaggggtcctgtcctccactccagatcattcctttagttta
gagctgggcagtgaagtggatatcactgaaggagataggaagccagactacactgcttac
gttgccatgatccctcagtgcataaaggaggaagacaccccttcagataatgatagtggc
atctgtatgagcccagagtcctatctggggtctcctcagcacagcccctctaccaggggc
tctccaaataggagcctcccatctccaggtgttctctgtgggtctgcccgtcccaaacct
tacgatcctcctggagagaagatggtagcagcaaaagtaaagggtgagaaactggataag
aagctgaaaaaaatggagcaaaacaagacagcagccactaggtaccgccagaagaagagg
gcggagcaggaggctcttactggtgagtgcaaagagctggaaaagaagaacgaggctcta
aaagagagggcggattccctggccaaggagatccagtacctgaaagatttgatagaagag
gtccgcaaggcaagggggaagaaaagggtcccctag

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