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ENTRY	nt06534
Name	Unfolded protein response
Category	Pathway view; Cellular processes
Pathway	hsa04141 Protein processing in endoplasmic reticulum
Display	drug-target relation   disease type

N01009            EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01010    AD     PSEN1* ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01035    PD SNCA* ⊣ BIP ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01149    ALS SOD1* ⊣ BIP ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01198    PrD PRNP* ⊣ BIP ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3   N01011            ERN1 → XBP1 ⇒ DDIT3 N01012    AD     PSEN1* ⊣ ERN1 → XBP1 N01034    PD SNCA* ⊣ BIP ⊣ ERN1 → XBP1 N01148    ALS SOD1* ⊣ BIP ⊣ ERN1 → XBP1   N01013            ERN1 → TRAF2 → MAP3K5 → MAP2K7 → JNK N01014    AD         APP* → Abeta → MAP3K5 → MAP2K7 → JNK   N01015            ATF6 ⇒ (DDIT3,XBP1,HSPA5) N01016    AD     PSEN1* ⊣ ATF6 ⇒ (DDIT3,XBP1) N01150    ALS     VAPB* ⊣ ATF6 N01033    PD SNCA* ⊣ BIP ⊣ ATF6 ⇒ DDIT3 N01147    ALS SOD1* ⊣ BIP ⊣ ATF6 ⇒ DDIT3

		Disease name	Disease category
AD	H00056	Alzheimer disease	Neurodegenerative disease
PD	H00057	Parkinson disease	Neurodegenerative disease
ALS	H00058	Amyotrophic lateral sclerosis (ALS)	Neurodegenerative disease
PrD	H00061	Prion disease	Neurodegenerative disease