KEGG   PATHWAY: aml05169
Entry
aml05169                    Pathway                                
Name
Epstein-Barr virus infection - Ailuropoda melanoleuca (giant panda)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
aml05169  Epstein-Barr virus infection
aml05169

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100482465  CR2; complement receptor type 2 isoform X1 [KO:K04012]
100471141  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
100464393  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100464636  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
100477284  HLA class II histocompatibility antigen, DM beta chain isoform X2 [KO:K06752]
100478290  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
100484974  HLA class II histocompatibility antigen, DQ beta 2 chain [KO:K06752]
100464780  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
100464279  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100478546  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100463634  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
100464025  LOW QUALITY PROTEIN: SLA class II histocompatibility antigen, DQ haplotype C alpha chain [KO:K06752]
100465129  TLR2; toll-like receptor 2 [KO:K10159]
100479307  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100469127  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100484977  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100483216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100484077  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
100468085  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100466506  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100466997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100471563  TNF; tumor necrosis factor [KO:K03156]
100477151  IL6; interleukin-6 precursor [KO:K05405]
117803984  interleukin-6-like [KO:K05405]
100469453  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
100482674  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100466406  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100484104  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100465112  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100474086  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
100471184  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100476812  interferon alpha-2 [KO:K05414]
100477312  interferon alpha-1/2 [KO:K05414]
100477562  LOW QUALITY PROTEIN: interferon alpha-1/2 [KO:K05414]
100478321  interferon alpha-1/2 [KO:K05414]
100478068  interferon alpha-like [KO:K05414]
100476556  IFNB1; interferon beta [KO:K05415]
100481921  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100482679  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
100473460  JAK1; tyrosine-protein kinase JAK1 isoform X2 [KO:K11217] [EC:2.7.10.2]
100468422  TYK2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100474026  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100472167  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100475480  IRF9; interferon regulatory factor 9 [KO:K04693]
100469151  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
100469118  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
100468112  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X2 [KO:K14216] [EC:2.7.7.84]
100469368  OAS3; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
100469693  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
100469387  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
100473767  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100468003  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
100472842  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100465439  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
100477763  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
100484344  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
100471095  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100472241  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100472074  cytochrome c [KO:K08738]
105241648  cytochrome c-like [KO:K08738]
100464163  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100483760  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100482462  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X2 [KO:K06451]
100484468  CD3G; T-cell surface glycoprotein CD3 gamma chain isoform X2 [KO:K06452]
100484718  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
100484298  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
117803402  T-cell surface glycoprotein CD3 zeta chain-like [KO:K06453]
100479952  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
117798292  26S proteasome regulatory subunit 7-like [KO:K03061]
100483435  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100469015  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100474244  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
100472740  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 10B [KO:K03064]
100476973  PSMC3; 26S proteasome regulatory subunit 6A isoform X2 [KO:K03065]
100471784  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
100470925  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100465828  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X2 [KO:K03032]
100481540  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100481520  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
100463710  PSMD11; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100468057  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100473896  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100467708  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105237685  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
100484033  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
100468437  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
100480012  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100465742  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100464886  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100478040  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100484836  TAPBP; tapasin [KO:K08058]
100472906  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100479734  CALR; calreticulin [KO:K08057]
100483904  AIME-1906; class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
100476691  AIME-152; class I histocompatibility antigen, Aime-152 precursor [KO:K06751]
100466374  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
100470568  AIME-128; DLA class I histocompatibility antigen, A9/A9 alpha chain [KO:K06751]
105241843  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0102 alpha chain [KO:K06751]
100465524  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751]
109488766  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100470489  B2M; beta-2-microglobulin [KO:K08055]
100465183  SNW1; SNW domain-containing protein 1 [KO:K06063]
100469649  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
100477344  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
100477725  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
100478424  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100483813  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
105236423  SAP30; LOW QUALITY PROTEIN: histone deacetylase complex subunit SAP30 [KO:K19202]
100473432  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
100472607  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
100467477  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100480511  RBPJ; recombining binding protein suppressor of hairless isoform X2 [KO:K06053]
100481439  HES1; transcription factor HES-1 [KO:K06054]
100467087  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
100474431  RUNX3; runt-related transcription factor 3 [KO:K09279]
100464396  MYC; myc proto-oncogene protein [KO:K04377]
100468835  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
100479481  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100468516  TP53; cellular tumor antigen p53 [KO:K04451]
100484923  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100477654  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100482871  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100470600  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100479738  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100464732  POLK; DNA polymerase kappa isoform X2 [KO:K03511] [EC:2.7.7.7]
100475872  TRAF5; TNF receptor-associated factor 5 isoform X2 [KO:K09849]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100472260  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
100477158  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
100474781  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
100483589  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100466767  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
100481976  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
100475919  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100475975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100477951  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100482196  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100477600  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100474087  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100469872  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100476678  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100469111  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100465223  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100465476  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100480235  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100480483  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100483834  JUN; transcription factor AP-1 [KO:K04448]
100468369  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
100473727  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
100474255  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
100476345  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
100475724  CD44; CD44 antigen isoform X7 [KO:K06256]
100464009  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
105239469  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
100476475  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100464155  VIM; vimentin [KO:K07606]
100474270  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
100474005  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100469938  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100479606  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100474543  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100464254  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100465648  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100472303  BTK; tyrosine-protein kinase BTK isoform X3 [KO:K07370] [EC:2.7.10.2]
100481331  BLNK; B-cell linker protein isoform X3 [KO:K07371]
100481994  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100480437  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
100467824  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100469787  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
100471517  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100479467  CCND3; G1/S-specific cyclin-D3 isoform X4 [KO:K10152]
100481236  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100476389  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
100482271  CCNA2; cyclin-A2 [KO:K06627]
100475180  CCNA1; cyclin-A1 [KO:K06627]
100471009  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100483627  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100468314  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100477714  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
117795744  E2F1; transcription factor E2F1 [KO:K17454]
100475779  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
100484544  E2F3; transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
aml03050  Proteasome
aml04010  MAPK signaling pathway
aml04020  Calcium signaling pathway
aml04064  NF-kappa B signaling pathway
aml04110  Cell cycle
aml04115  p53 signaling pathway
aml04210  Apoptosis
aml04612  Antigen processing and presentation
aml04620  Toll-like receptor signaling pathway
aml04622  RIG-I-like receptor signaling pathway
aml04630  JAK-STAT signaling pathway
aml04662  B cell receptor signaling pathway
KO pathway
ko05169   
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