KEGG   PATHWAY: myd04010
Entry
myd04010                    Pathway                                
Name
MAPK signaling pathway - Myotis davidii (David's myotis)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
myd04010  MAPK signaling pathway
myd04010

Other DBs
GO: 0000165
Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102771143  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
102756826  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
102753812  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102761441  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102766294  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
102771414  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102771111  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
102751301  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
102760374  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102774068  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
102763556  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
102752991  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
102757287  CACNB1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
102767759  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
102765261  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
102752339  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
102761083  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
102769959  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
102775081  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
102760798  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
102765943  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
102755466  CACNG6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
102755749  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102759840  cGMP-dependent protein kinase 1 [KO:K04345] [EC:2.7.11.11]
102772218  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102773780  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102765661  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102757004  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102756030  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102763801  GNA12; G protein subunit alpha 12 [KO:K04346]
102752682  GNG12; G protein subunit gamma 12 [KO:K04347]
102773554  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
102755500  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102753757  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102754623  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102774846  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102760712  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102755043  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
102755145  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
102758449  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
102766192  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102754347  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102763301  RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
102762387  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102762259  NF1; neurofibromin 1 [KO:K08052]
102760886  RASA1; RAS p21 protein activator 1 [KO:K04352]
102762518  RASA2; RAS p21 protein activator 2 [KO:K08053]
102774675  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102772411  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102758044  EGF; epidermal growth factor [KO:K04357]
102768972  TGFA; transforming growth factor alpha [KO:K08774]
102756004  EREG; epiregulin [KO:K09784]
102755058  AREG; amphiregulin [KO:K09782]
102766495  FGF1; fibroblast growth factor 1 [KO:K18496]
102762815  FGF2; fibroblast growth factor 2 [KO:K18497]
102754856  FGF6; fibroblast growth factor 6 [KO:K04358]
102760407  FGF7; fibroblast growth factor 7 [KO:K04358]
102764131  FGF8; fibroblast growth factor 8 [KO:K04358]
102753348  FGF9; fibroblast growth factor 9 [KO:K04358]
102769868  FGF5; fibroblast growth factor 5 [KO:K04358]
102755169  FGF17; fibroblast growth factor 17 [KO:K04358]
102769456  FGF16; fibroblast growth factor 16 [KO:K04358]
102757267  FGF3; fibroblast growth factor 3 [KO:K04358]
102751896  FGF18; fibroblast growth factor 18 [KO:K04358]
102754068  FGF22; fibroblast growth factor 22 [KO:K04358]
102766184  FGF10; fibroblast growth factor 10 [KO:K04358]
102768942  FGF21; fibroblast growth factor 21 [KO:K22429]
102769020  NGF; nerve growth factor [KO:K02582]
102754946  BDNF; brain derived neurotrophic factor [KO:K04355]
102770063  NTF3; neurotrophin 3 [KO:K04356]
102766351  NTF4; neurotrophin 4 [KO:K12457]
102753598  INS; insulin [KO:K04526]
102752580  IGF1; insulin like growth factor 1 [KO:K05459]
102762551  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102752730  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102766117  PDGFC; platelet derived growth factor C [KO:K05450]
102772727  PDGFD; platelet derived growth factor D [KO:K05450]
102766818  CSF1; colony stimulating factor 1 [KO:K05453]
102756911  KITLG; KIT ligand [KO:K05461]
102771975  VEGFA; vascular endothelial growth factor A [KO:K05448]
102755405  VEGFB; vascular endothelial growth factor B [KO:K16858]
102761298  PGF; placental growth factor [KO:K16859]
102770606  VEGFC; vascular endothelial growth factor C [KO:K05449]
102764314  VEGFD; vascular endothelial growth factor D [KO:K05449]
102765945  HGF; hepatocyte growth factor [KO:K05460]
102764294  ANGPT1; angiopoietin 1 [KO:K05465]
102768197  ANGPT2; angiopoietin 2 [KO:K05466]
102762702  ANGPT4; angiopoietin 4 [KO:K05467]
102758595  EFNA5; ephrin A5 [KO:K05462]
102760889  EFNA4; ephrin A4 [KO:K05462]
102761173  EFNA3; ephrin A3 [KO:K05462]
102757196  EFNA1; ephrin A1 [KO:K05462]
102758556  EFNA2; ephrin A2 [KO:K05462]
102767860  GDNF; glial cell derived neurotrophic factor [KO:K05452]
102755090  NRTN; neurturin [KO:K25414]
102753683  PSPN; persephin [KO:K25416]
102775204  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102771013  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102774755  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102765674  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102759202  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102763283  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102759469  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102774816  NGFR; nerve growth factor receptor [KO:K02583]
102765751  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
102755544  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
102766590  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102770795  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102761943  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102764172  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102763897  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102761085  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102760103  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102760394  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102755891  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102756633  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102760801  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102753524  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102773744  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102756217  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102766212  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
102754991  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102768105  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102763262  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102762537  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102762284  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102761492  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102770869  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
102765159  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102757500  MRAS; muscle RAS oncogene homolog [KO:K07831]
102755690  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102760422  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102772748  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102763997  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102757282  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102773859  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102769037  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102775211  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102751797  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
102774479  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
102762494  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102764080  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102767347  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102757884  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102763654  ATF4; activating transcription factor 4 [KO:K04374]
102755127  ELK1; ELK1, ETS transcription factor [KO:K04375]
102755135  ELK4; ELK4, ETS transcription factor [KO:K04376]
102758544  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102764136  SRF; serum response factor [KO:K04378]
102764239  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102757836  MAPT; microtubule associated protein tau [KO:K04380]
102751483  STMN1; stathmin 1 [KO:K04381]
102770531  stathmin [KO:K04381]
102754320  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
102754611  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
102774327  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
102771796  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
102772466  JMJD7; jumonji domain containing 7 [KO:K16342] [EC:3.1.1.4]
102758774  TNF; tumor necrosis factor [KO:K03156]
102770100  IL1A; interleukin 1 alpha [KO:K04383]
102769803  IL1B; interleukin 1 beta [KO:K04519]
102752983  TGFB1; transforming growth factor beta 1 [KO:K13375]
102755920  TGFB2; transforming growth factor beta 2 [KO:K13376]
102767291  TGFB3; transforming growth factor beta 3 [KO:K13377]
102768884  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102775132  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
102771155  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
102765185  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
102767756  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102759597  FASLG; Fas ligand [KO:K04389]
102760302  FAS; Fas cell surface death receptor [KO:K04390]
102773178  CD14; CD14 molecule [KO:K04391]
102759477  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102768116  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102760578  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102758165  CDC42; cell division cycle 42 [KO:K04393]
102757347  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102760961  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102772361  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102756594  DAXX; death domain associated protein [KO:K02308]
107183283  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102765985  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102754676  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102765934  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102771581  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
102751752  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102752386  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102752149  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102770532  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
102763605  ECSIT; ECSIT signalling integrator [KO:K04405]
102756817  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
102771523  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
102763878  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
102755302  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102752411  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102769615  STK4; serine/threonine kinase 4 [KO:K04411]
102759803  STK3; serine/threonine kinase 3 [KO:K04412]
102753159  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102775461  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102763786  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102771577  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102753581  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102762787  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
102756379  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102751509  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102753749  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
102773021  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102753720  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102770852  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
102770934  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
102771311  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102763957  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102757393  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102751436  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
102765553  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
102772269  TAOK2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
102769098  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102760954  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102765923  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102759247  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102767242  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
102773452  MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
102773245  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
102764268  FLNA; filamin A [KO:K04437]
102758195  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102761799  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102770259  ARRB1; arrestin beta 1 [KO:K04439]
102765545  ARRB2; arrestin beta 2 [KO:K04439]
102772062  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102764416  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102775351  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102770309  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102770021  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102755728  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102756012  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102757546  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
102775090  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102757924  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102754112  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
102753709  RPS6KA4; ribosomal protein S6 kinase A4 [KO:K16510] [EC:2.7.11.1]
102766417  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
102753689  M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
102763205  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
102765232  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
107183844  JUNB; JunB proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102752693  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102761389  ATF2; activating transcription factor 2 [KO:K04450]
102759012  TP53; tumor protein p53 [KO:K04451]
102764039  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102775328  MAX; MYC associated factor X [KO:K04453]
102763270  MEF2C; myocyte enhancer factor 2C [KO:K04454]
102773748  heat shock protein beta-1-like [KO:K04455]
102752420  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
102772266  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102773065  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102754169  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
102759120  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
102765900  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
102761657  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102760550  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102763513  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102773333  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102765113  DUSP2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102754387  dual specificity protein phosphatase 5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102768617  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102754339  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102753896  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102757190  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102767689  DUSP9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102752753  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102764606  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102771462  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
102762240  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
102774775  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
102772438  heat shock cognate 71 kDa protein-like [KO:K03283]
102764580  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
102764862  heat shock 70 kDa protein 1-like [KO:K03283]
102766636  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
102756005  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
102769984  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102764884  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102762988  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102760888  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102773824  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102772051  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102760175  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
102770715  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102762701  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
102770704  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102759568  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
myd04070  Phosphatidylinositol signaling system
myd04110  Cell cycle
myd04115  p53 signaling pathway
myd04210  Apoptosis
myd04310  Wnt signaling pathway
myd04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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