KEGG   PATHWAY: nss04010
Entry
nss04010                    Pathway                                
Name
MAPK signaling pathway - Notechis scutatus (mainland tiger snake)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
nss04010  MAPK signaling pathway
nss04010

Other DBs
GO: 0000165
Organism
Notechis scutatus (mainland tiger snake) [GN:nss]
Gene
113418247  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
113424785  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
113419359  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
113417804  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
113413121  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
113417797  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
113411908  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
113422377  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
113432707  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
113418846  voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857]
113418965  voltage-dependent L-type calcium channel subunit alpha-1S-like [KO:K04857]
113412330  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
113415699  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
113417815  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
113420025  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
113424623  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
113418459  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
113420241  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
113420250  voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
113419422  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
113430927  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
113423126  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
113419378  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
113419380  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
113418515  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
113418604  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
113418603  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
113418177  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
113419166  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
113419423  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113423120  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
113418514  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
113423705  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
113411096  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
113415342  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113420963  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113412701  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
113423340  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
113414119  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
113410113  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
113424368  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
113420749  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
113417434  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
113420498  NF1; neurofibromin isoform X1 [KO:K08052]
113414139  RASA1; ras GTPase-activating protein 1 [KO:K04352]
113410083  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
113417007  RAP1A; ras-related protein Rap-1A [KO:K04353]
113412267  RAP1B; ras-related protein Rap-1b [KO:K07836]
113412783  EGF; pro-epidermal growth factor [KO:K04357]
113423376  TGFA; protransforming growth factor alpha [KO:K08774]
113420090  proepiregulin-like [KO:K09784]
113420089  AREG; amphiregulin [KO:K09782]
113423689  FGF1; fibroblast growth factor 1 [KO:K18496]
113411891  FGF2; fibroblast growth factor 2 [KO:K18497]
113414222  FGF22; fibroblast growth factor 22 [KO:K04358]
113410179  FGF3; fibroblast growth factor 3 [KO:K04358]
113410180  FGF4; fibroblast growth factor 4 [KO:K04358]
113416878  FGF9; fibroblast growth factor 9 [KO:K04358]
113411419  FGF10; fibroblast growth factor 10 [KO:K04358]
113411764  FGF20; fibroblast growth factor 20 [KO:K04358]
113412135  FGF8; fibroblast growth factor 8 [KO:K04358]
113417897  FGF5; fibroblast growth factor 5 [KO:K04358]
113412671  FGF18; LOW QUALITY PROTEIN: fibroblast growth factor 18 [KO:K04358]
113418291  FGF7; fibroblast growth factor 7 [KO:K04358]
113423483  FGF16; fibroblast growth factor 16 [KO:K04358]
113410182  FGF19; fibroblast growth factor 19 [KO:K22603]
113418621  FGF21; fibroblast growth factor 21 [KO:K22429]
113418410  FGF23; fibroblast growth factor 23 [KO:K22428]
113420784  NGF; beta-nerve growth factor [KO:K02582]
113410188  BDNF; brain-derived neurotrophic factor [KO:K04355]
113419744  NTF3; neurotrophin-3 [KO:K04356]
113413354  NTF4; neurotrophin-4 [KO:K12457]
113412472  INS; insulin [KO:K04526]
113432811  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
113412545  IGF2; insulin-like growth factor II [KO:K13769]
113423617  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
113432717  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
113417310  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
113417441  PDGFC; platelet-derived growth factor C [KO:K05450]
113418820  macrophage colony-stimulating factor 1-like [KO:K05453]
113418946  macrophage colony-stimulating factor 1-like [KO:K05453]
113431265  KITLG; kit ligand isoform X1 [KO:K05461]
113420948  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
113429702  vascular endothelial growth factor A-like [KO:K05448]
113409940  PGF; placenta growth factor isoform X1 [KO:K16859]
113411878  VEGFC; vascular endothelial growth factor C [KO:K05449]
113412333  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
113427348  ANGPT1; angiopoietin-1 [KO:K05465]
113420656  angiopoietin-2-like [KO:K05466]
113410621  ANGPT2; angiopoietin-2 [KO:K05466]
113415518  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
113429343  EFNA1; ephrin-A1 [KO:K05462]
113430447  ephrin-A4-like [KO:K05462]
113423653  EFNA2; ephrin-A2 [KO:K05462]
113411323  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
113428017  neurturin-like [KO:K25414]
113428128  neurturin-like [KO:K25414]
113410939  ARTN; artemin [KO:K25415]
113422095  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113420001  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
113419399  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
113415660  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
113420990  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
113413341  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113427454  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
113415824  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113425517  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
113413460  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
113424285  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
113416674  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113414184  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
113415602  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
113422760  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113424511  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
113423624  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
113422761  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
113416920  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
113416918  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
113419295  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
113424522  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
113422759  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
113413069  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
113415052  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
113423132  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
113419135  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
113412064  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113414133  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113420311  SOS1; son of sevenless homolog 1 [KO:K03099]
113412507  HRAS; GTPase HRas [KO:K02833]
113418546  GTPase HRas isoform X1 [KO:K07827]
113419054  KRAS; GTPase KRas isoform X1 [KO:K07827]
113416978  NRAS; GTPase NRas [KO:K07828]
113412588  RRAS2; ras-related protein R-Ras2 [KO:K07830]
113413422  ras-related protein R-Ras2-like [KO:K07830]
113410775  MRAS; ras-related protein M-Ras [KO:K07831]
113417793  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
113432841  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
113418209  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113415615  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113425513  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113415336  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
113424609  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113421765  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
113420936  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
113410991  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
113416643  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
113416832  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
113417040  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
113417593  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
113432708  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113422968  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
113418117  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
113419634  MYC; myc proto-oncogene protein [KO:K04377]
113422702  SRF; serum response factor isoform X1 [KO:K04378]
113410033  FOS; proto-oncogene c-Fos [KO:K04379]
113420030  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
113417584  STMN1; stathmin [KO:K04381]
113414236  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113414252  LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113414253  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113414372  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113414373  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113409993  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
113409996  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113410158  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
113426287  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113426288  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
113413195  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
113424585  TNF; tumor necrosis factor [KO:K03156]
113423381  IL1B; interleukin-1 beta [KO:K04519]
113426022  TGFB1; transforming growth factor beta-1 [KO:K13375]
113421978  TGFB2; transforming growth factor beta-2 [KO:K13376]
113410027  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
113417192  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
113411623  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
113411624  interleukin-1 receptor-like 2 isoform X1 [KO:K04386]
113426163  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
113419091  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
113410743  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
113421110  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
113421451  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113425161  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113425273  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113432389  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113432756  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
113412010  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113427574  CDC42; cell division control protein 42 homolog [KO:K04393]
113414958  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113411860  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
113424253  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
113430715  DAXX; death domain-associated protein 6 [KO:K02308]
113419506  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
113417693  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
113412310  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113410230  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113416315  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
113411095  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
113430869  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
113432712  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
113411242  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
113419949  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
113423066  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
113416698  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
113411726  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
113427689  mitogen-activated protein kinase kinase kinase kinase 1-like [KO:K04408] [EC:2.7.11.1]
113429752  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
113410454  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
113427918  STK3; serine/threonine-protein kinase 3 [KO:K04412]
113424370  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
113415002  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
113413899  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
113428634  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
113428655  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
113410690  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
113420074  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
113419489  mitogen-activated protein kinase kinase kinase 2-like [KO:K04421] [EC:2.7.11.25]
113414379  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
113413301  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
113418477  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
113426125  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
113418687  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
113411203  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
113417608  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
113411493  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113417052  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
113425294  serine/threonine-protein kinase TAO2-like isoform X1 [KO:K04429] [EC:2.7.11.1]
113421694  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
113423292  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
113412143  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
113418170  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113423604  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
113417417  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113414387  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
113429999  C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
113421847  MAPK8IP3; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
113417708  FLNA; filamin-A isoform X1 [KO:K04437]
113426559  CRK; adapter molecule crk [KO:K04438]
113421719  crk-like protein [KO:K04438]
113422144  CRKL; crk-like protein [KO:K04438]
113432517  beta-arrestin-2-like [KO:K04439]
113424757  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113426188  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113422608  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113413033  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
113413034  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
113418781  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113418784  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113418976  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113418977  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113426801  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
113418093  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
113415738  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
113419663  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
113426329  RPS6KA4; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
113413574  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
113414896  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
113411064  JUN; transcription factor AP-1 [KO:K04448]
113414202  JUND; transcription factor jun-D [KO:K04449]
113418677  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113427879  cellular tumor antigen p53-like [KO:K04451]
113416174  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
113410860  MAX; protein max isoform X1 [KO:K04453]
113415013  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
113415156  HSPB1; heat shock protein beta-1 [KO:K04455]
113425569  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113413278  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113413668  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113413701  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
113412175  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
113412564  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
113420807  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
113425923  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
113415462  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113417941  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113422525  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113412535  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113431947  dual specificity protein phosphatase 16-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
113431284  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
113421755  DUSP10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
113427054  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
113413438  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
113425801  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
113422480  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
113424307  heat shock 70 kDa protein II-like [KO:K03283]
113424339  LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
113426357  heat shock cognate 71 kDa protein [KO:K03283]
113421207  heat shock cognate 71 kDa protein-like [KO:K03283]
113411115  MECOM; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
113411805  MDS1 and EVI1 complex locus protein-like [KO:K04462] [EC:2.1.1.367]
113415572  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
113422517  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
113420181  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
113422085  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
113425188  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
113427675  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113417663  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113421730  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
113422014  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
113415345  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
113415385  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
113426424  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
nss04070  Phosphatidylinositol signaling system
nss04110  Cell cycle
nss04115  p53 signaling pathway
nss04210  Apoptosis
nss04310  Wnt signaling pathway
KO pathway
ko04010   
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