KEGG   PATHWAY: oaa05205
Entry
oaa05205                    Pathway                                
Name
Proteoglycans in cancer - Ornithorhynchus anatinus (platypus)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
oaa05205  Proteoglycans in cancer
oaa05205

Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100076581  CD44; CD44 antigen isoform X1 [KO:K06256]
107547224  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100075800  CTTN; src substrate cortactin isoform X1 [KO:K06106]
100090532  HCLS1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
100091139  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100075806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100075831  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100073433  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100085604  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
114809992  HRAS; GTPase HRas [KO:K02833]
100085430  KRAS; GTPase KRas isoform X1 [KO:K07827]
100074671  NRAS; GTPase NRas [KO:K07828]
114814624  RRAS; ras-related protein R-Ras [KO:K07829]
100090494  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103169212  MRAS; ras-related protein M-Ras [KO:K07831]
100086380  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100089456  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100084423  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
100080362  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100087942  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100085480  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100086487  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100085128  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100086186  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100681469  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
120637981  ESR1; estrogen receptor isoform X1 [KO:K08550]
100075081  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100085078  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100092493  actin, cytoplasmic type 5 [KO:K05692]
100078865  ACTB; actin, cytoplasmic 1 [KO:K05692]
100077046  FLNA; filamin-A isoform X1 [KO:K04437]
100086384  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100088712  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100078658  ARHGEF1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
100073519  RHOA; transforming protein RhoA isoform X2 [KO:K04513]
100079193  transforming protein RhoA-like [KO:K04513]
100079648  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100073941  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
100079190  ANK1; ankyrin-1 isoform X1 [KO:K10380]
100076099  ANK2; ankyrin-2 isoform X1 [KO:K09255]
100078612  ANK3; ankyrin-3 isoform X1 [KO:K09259]
100082582  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100083320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100081473  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100090267  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100088668  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100074395  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X3 [KO:K06269] [EC:3.1.3.16]
100078635  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100092226  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100077235  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100077407  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
100087416  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
100073922  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
103169567  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
100075749  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
103164954  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100088770  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100089453  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100079279  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100074083  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100089905  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
107547678  NANOG; homeobox protein NANOG [KO:K10164]
100079853  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
100076303  DROSHA; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
100087932  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
100314554  MIR21; oan-miR-21-5p [KO:K16863]
100083743  TWIST1; twist-related protein 1 [KO:K09069]
100079967  TWIST2; twist-related protein 2 [KO:K09069]
100314542  MIR10A; oan-miR-10a-5p [KO:K16864]
100314574  MIR10B; oan-miR-10b-5p [KO:K17393]
100084660  HOXD10; homeobox protein Hox-D10 [KO:K09295]
100079988  DCN; decorin [KO:K04660]
100075905  IGF1; insulin-like growth factor I isoform X7 [KO:K05459]
100077556  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100079751  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100089083  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100087780  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100078852  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100090195  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
100074741  RPS6; 40S ribosomal protein S6 [KO:K02991]
100075894  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100079536  CAV1; caveolin-1 [KO:K06278]
100091379  caveolin-2 [KO:K12958]
114814756  CAV2; caveolin-2 [KO:K12958]
114806542  CAV3; caveolin-3 [KO:K12959]
103171193  CD63; CD63 antigen [KO:K06497]
114813305  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100087105  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
114812005  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
100081248  TLR2; toll-like receptor 2 [KO:K10159]
114811053  TLR4; toll-like receptor 4 [KO:K10160]
100080517  PDCD4; programmed cell death protein 4 [KO:K16865]
100085643  TNF; tumor necrosis factor [KO:K03156]
100074930  IL12B; interleukin-12 subunit beta [KO:K05425]
100079793  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100077353  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100079391  MYC; myc proto-oncogene protein [KO:K04377]
100080628  CTNNB1; catenin beta-1 [KO:K02105]
100080039  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
100093136  TFAP4; transcription factor AP-4 isoform X1 [KO:K09108]
100077009  VEGFA; vascular endothelial growth factor A [KO:K05448]
100075389  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
100079345  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100091424  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
103170776  TIMP3; metalloproteinase inhibitor 3 isoform X1 [KO:K16866]
100092988  THBS1; thrombospondin-1 [KO:K16857]
100077120  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
103166153  epididymal sperm-binding protein 1-like [KO:K01398] [EC:3.4.24.24]
100080022  LUM; lumican [KO:K08122]
100081646  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103165091  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100080712  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100092821  TP53; cellular tumor antigen p53 [KO:K04451]
100080176  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
100076734  HPSE2; inactive heparanase-2 [KO:K07965] [EC:3.2.1.-]
100087402  SDC1; syndecan-1 [KO:K06257]
100079618  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
114812017  PLAUR; urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
100681278  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100078516  COL27A1; collagen alpha-1(XXVII) chain [KO:K06236]
100079519  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100076348  ITGA2; integrin alpha-2 [KO:K06481]
100073959  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100086729  VTN; vitronectin [KO:K06251]
100085661  ITGAV; integrin alpha-V [KO:K06487]
100087119  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100078116  FN1; fibronectin isoform X5 [KO:K05717]
100083529  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
100074892  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
114814562  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100081860  FZD7; frizzled-7 [KO:K02432]
114813907  FZD1; frizzled-1 [KO:K02432]
100090775  FZD2; frizzled-2 [KO:K02235]
100086058  FZD3; frizzled-3 [KO:K02329]
100080994  FZD4; frizzled-4 [KO:K02354]
100089547  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
114816216  FZD8; frizzled-8 [KO:K02375]
100080710  FZD6; frizzled-6 [KO:K02376]
100091844  FZD10; frizzled-10 [KO:K02842]
100080214  FZD9; frizzled-9 [KO:K02842]
100090507  ITGA5; integrin alpha-5 [KO:K06484]
100073947  SDC2; syndecan-2 [KO:K16336]
100090068  EZR; ezrin [KO:K08007]
100076248  RDX; radixin isoform X1 [KO:K05762]
100089510  MSN; moesin [KO:K05763]
100084859  SDC4; syndecan-4 [KO:K16338]
114815531  FGF2; fibroblast growth factor 2 [KO:K18497]
100074240  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100080990  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
100089978  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100086381  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
100084645  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100078989  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100078757  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100076776  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100079107  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100074181  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100085442  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100076455  NUDT16L1; tudor-interacting repair regulator protein isoform X1 [KO:K16867]
100092267  PXN; paxillin isoform X1 [KO:K05760]
100076789  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100093606  HBEGF; LOW QUALITY PROTEIN: proheparin-binding EGF-like growth factor [KO:K08523]
100084479  GPC1; glypican-1 [KO:K08107]
791102  IGF2; insulin-like growth factor II [KO:K13769]
100084108  GPC3; glypican-3 isoform X1 [KO:K08109]
100077640  WNT2; protein Wnt-2 precursor [KO:K00182]
100087253  WNT2B; protein Wnt-2b [KO:K00182]
100090103  WNT3A; LOW QUALITY PROTEIN: protein Wnt-3a [KO:K00312]
100075238  WNT4; protein Wnt-4 [KO:K00408]
100085809  WNT5B; protein Wnt-5b [KO:K00444]
100088897  WNT5A; protein Wnt-5a [KO:K00444]
100089786  WNT6; protein Wnt-6 [KO:K00445]
100075994  WNT7A; protein Wnt-7a [KO:K00572]
100093588  WNT7B; protein Wnt-7b [KO:K00572]
100088910  protein Wnt-7a-like [KO:K00572]
100079874  WNT8B; protein Wnt-8b [KO:K00714]
100085370  WNT8A; protein Wnt-8a [KO:K00714]
100074117  WNT9A; protein Wnt-9a [KO:K01064]
100090678  WNT10A; protein Wnt-10a [KO:K01357]
107547159  WNT10B; protein Wnt-10b [KO:K01357]
100091700  WNT11; protein Wnt-11 [KO:K01384]
100077974  WNT16; protein Wnt-16 [KO:K01558]
100081692  SHH; sonic hedgehog protein [KO:K11988]
114811996  IHH; indian hedgehog protein [KO:K11989]
100079214  PTCH1; protein patched homolog 1 isoform X2 [KO:K06225]
100078770  SMO; smoothened homolog [KO:K06226]
100093007  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
100093403  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
100093369  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
100076077  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
100093360  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
100084840  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
100078846  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100088079  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100078507  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100091330  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100092264  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100093026  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100087350  HSPB2; LOW QUALITY PROTEIN: heat shock protein beta-2 [KO:K09543]
100089663  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
  Authors
Munesue S, Kusano Y, Oguri K, Itano N, Yoshitomi Y, Nakanishi H, Yamashina I, Okayama M
  Title
The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones.
  Journal
Biochem J 363:201-9 (2002)
DOI:10.1042/bj3630201
Reference
PMID:10687947
  Authors
Nugent MA, Iozzo RV
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:115-20 (2000)
DOI:10.1016/S1357-2725(99)00123-5
Reference
PMID:10633082
  Authors
Baciu PC, Saoncella S, Lee SH, Denhez F, Leuthardt D, Goetinck PF
  Title
Syndesmos, a protein that interacts with the cytoplasmic domain of syndecan-4, mediates cell spreading and actin cytoskeletal organization.
  Journal
J Cell Sci 113 Pt 2:315-24 (2000)
Reference
PMID:12509413
  Authors
Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, Mercurio AM, Couchman JR, Wewer UM
  Title
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.
  Journal
J Biol Chem 278:9576-84 (2003)
DOI:10.1074/jbc.M208937200
Reference
PMID:14711376
  Authors
Beauvais DM, Rapraeger AC
  Title
Syndecans in tumor cell adhesion and signaling.
  Journal
Reprod Biol Endocrinol 2:3 (2004)
DOI:10.1186/1477-7827-2-3
Reference
PMID:17971838
  Authors
Morgan MR, Humphries MJ, Bass MD
  Title
Synergistic control of cell adhesion by integrins and syndecans.
  Journal
Nat Rev Mol Cell Biol 8:957-69 (2007)
DOI:10.1038/nrm2289
Reference
PMID:18505598
  Authors
Filmus J, Capurro M, Rast J
  Title
Glypicans.
  Journal
Genome Biol 9:224 (2008)
DOI:10.1186/gb-2008-9-5-224
Reference
PMID:23305321
  Authors
Filmus J, Capurro M
  Title
Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma.
  Journal
FEBS J 280:2471-6 (2013)
DOI:10.1111/febs.12126
Reference
PMID:22563565
  Authors
Gao W, Ho M
  Title
The role of glypican-3 in regulating Wnt in hepatocellular carcinomas.
  Journal
Cancer Rep 1:14-19 (2011)
Reference
PMID:24412155
  Authors
Filmus J, Capurro M
  Title
The role of glypicans in Hedgehog signaling.
  Journal
Matrix Biol 35:248-52 (2014)
DOI:10.1016/j.matbio.2013.12.007
Reference
PMID:18413366
  Authors
Cheng W, Tseng CJ, Lin TT, Cheng I, Pan HW, Hsu HC, Lee YM
  Title
Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathway.
  Journal
Carcinogenesis 29:1319-26 (2008)
DOI:10.1093/carcin/bgn091
Reference
PMID:21155971
  Authors
Iozzo RV, Sanderson RD
  Title
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.
  Journal
J Cell Mol Med 15:1013-31 (2011)
DOI:10.1111/j.1582-4934.2010.01236.x
Reference
PMID:18949819
  Authors
Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN
  Title
Lumican, a small leucine-rich proteoglycan.
  Journal
IUBMB Life 60:818-23 (2008)
DOI:10.1002/iub.131
Related
pathway
oaa04010  MAPK signaling pathway
oaa04020  Calcium signaling pathway
oaa04066  HIF-1 signaling pathway
oaa04150  mTOR signaling pathway
oaa04151  PI3K-Akt signaling pathway
oaa04210  Apoptosis
oaa04310  Wnt signaling pathway
oaa04340  Hedgehog signaling pathway
oaa04350  TGF-beta signaling pathway
oaa04370  VEGF signaling pathway
oaa04510  Focal adhesion
oaa04520  Adherens junction
oaa04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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