KEGG   PATHWAY: pruf04010
Entry
pruf04010                   Pathway                                
Name
MAPK signaling pathway - Pyrgilauda ruficollis (rufous-necked snowfinch)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pruf04010  MAPK signaling pathway
pruf04010

Other DBs
GO: 0000165
Organism
Pyrgilauda ruficollis (rufous-necked snowfinch) [GN:pruf]
Gene
121357669  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
121362733  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
121350165  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
121359740  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
121362313  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
121363854  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
121350840  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04855]
121361109  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
121365422  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
121357357  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
121352495  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
121351554  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
121362745  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
121351096  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
121363965  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
121356304  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
121353455  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
121363380  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
121361189  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
121365845  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
121363377  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
121363379  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
121361926  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121363372  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121365824  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
121350703  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
121356116  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121366013  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121356767  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121362608  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
121358707  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
121352245  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
121351289  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
121349565  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
121358810  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
121360217  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
121361734  NF1; neurofibromin [KO:K08052]
121359715  ras GTPase-activating protein 1-like [KO:K04352]
121358011  ras GTPase-activating protein 1 isoform X1 [KO:K04352]
121357961  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
121353155  RAP1A; ras-related protein Rap-1A [KO:K04353]
121352517  RAP1B; ras-related protein Rap-1b [KO:K07836]
121360365  EGF; pro-epidermal growth factor [KO:K04357]
121353986  TGFA; protransforming growth factor alpha [KO:K08774]
121349322  EREG; proepiregulin [KO:K09784]
121349336  AREG; amphiregulin [KO:K09782]
121365607  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121361519  FGF2; fibroblast growth factor 2 [KO:K18497]
121364235  FGF9; fibroblast growth factor 9 [KO:K04358]
121364332  FGF6; fibroblast growth factor 6 [KO:K04358]
121365279  FGF10; fibroblast growth factor 10 [KO:K04358]
121354474  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121360303  FGF20; fibroblast growth factor 20 [KO:K04358]
121349098  FGF3; fibroblast growth factor 3 [KO:K04358]
121349099  FGF4; fibroblast growth factor 4 [KO:K04358]
121349333  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121360635  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
121355098  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
121350241  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121362807  FGF16; fibroblast growth factor 16 [KO:K04358]
121349094  FGF19; fibroblast growth factor 19 [KO:K22603]
121364344  FGF23; fibroblast growth factor 23 [KO:K22428]
121349758  NGF; beta-nerve growth factor [KO:K02582]
121363021  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
121349673  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
121361012  INS; insulin [KO:K04526]
121363553  IGF1; insulin-like growth factor I [KO:K05459]
121361011  IGF2; insulin-like growth factor II [KO:K13769]
121350738  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121361210  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
121364229  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121360372  PDGFC; platelet-derived growth factor C [KO:K05450]
121365460  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
121357229  KITLG; kit ligand isoform X1 [KO:K05461]
121358564  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
121356054  PGF; placenta growth factor isoform X1 [KO:K16859]
121360382  VEGFC; vascular endothelial growth factor C [KO:K05449]
121356236  VEGFD; vascular endothelial growth factor D [KO:K05449]
121357407  HGF; hepatocyte growth factor [KO:K05460]
121355399  ANGPT1; angiopoietin-1 [KO:K05465]
121358907  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
121348573  ANGPT4; angiopoietin-4 [KO:K05467]
121361174  EFNA2; ephrin-A2 [KO:K05462]
121352122  EFNA5; ephrin-A5 [KO:K05462]
121352155  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
121352157  EFNA1; ephrin-A1 [KO:K05462]
121352177  uncharacterized protein LOC121352177 [KO:K05462]
121356171  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
121352707  NRTN; neurturin isoform X1 [KO:K25414]
121362163  ARTN; artemin isoform X1 [KO:K25415]
121352949  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121351120  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
121364430  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
121359634  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121350260  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121348993  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121361408  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
121352417  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
121352173  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
121360713  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
121360714  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
121354271  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121349389  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121361297  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
121361298  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
121348846  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
121364124  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
121364149  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121362872  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
121361337  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
121356907  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
121355793  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121363708  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
121351404  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
121357411  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
121363830  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121358630  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121348679  SOS2; son of sevenless homolog 2 [KO:K03099]
121360994  HRAS; GTPase HRas [KO:K02833]
121354764  KRAS; GTPase KRas [KO:K07827]
121349762  NRAS; GTPase NRas [KO:K07828]
121360950  RRAS2; ras-related protein R-Ras2 [KO:K07830]
121356604  MRAS; ras-related protein M-Ras [KO:K07831]
121364303  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121349059  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121354353  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121349910  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121362627  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
121365143  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121353358  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
121362049  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
121349805  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
121356155  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121351243  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121363044  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
121361103  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121355229  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
121364668  MYC; myc proto-oncogene protein [KO:K04377]
121357347  SRF; serum response factor [KO:K04378]
121355973  FOS; proto-oncogene c-Fos [KO:K04379]
121352427  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
121351200  STMN1; stathmin [KO:K04381]
121360116  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
121349395  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
121349471  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
121349479  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
121349480  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
121349482  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
121349505  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
121349541  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
121349542  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
121349543  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
121348557  tumor necrosis factor-like [KO:K03156]
121359483  IL1B; interleukin-1 beta [KO:K04519]
121358714  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
121355988  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
121351612  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
121354092  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
121353838  interleukin-1 receptor accessory protein [KO:K04723]
121349262  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121353051  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
121356695  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
121359744  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121350122  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
121350603  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121361104  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
121352797  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
121365792  CDC42; cell division control protein 42 homolog [KO:K04393]
121348864  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
121360209  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
121357539  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
121365519  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
121352494  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
121360996  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121363946  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
121356115  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
121361701  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
121361228  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
121354820  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
121358563  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
121354057  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
121363074  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
121350522  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121364029  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
121359711  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
121355423  STK3; serine/threonine-protein kinase 3 [KO:K04412]
121364572  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
121355416  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
121351434  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
121356542  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
121364634  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
121352471  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
121349481  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
121363303  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
121356095  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
121364073  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
121356760  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
121354869  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
121360539  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121358675  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
121364951  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
121361839  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
121352721  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
121359336  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
121350851  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
121363365  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
121349528  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
121362765  C-Jun-amino-terminal kinase-interacting protein 2-like [KO:K04435]
121350619  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
121364856  CRKL; crk-like protein [KO:K04438]
121361767  CRK; adapter molecule crk isoform X1 [KO:K04438]
121354724  beta-arrestin-1 isoform X1 [KO:K04439]
121365224  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121350038  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121361485  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121353388  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121353401  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121355781  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
121364813  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
121349766  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
121352486  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
121355957  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
121352021  uncharacterized protein LOC121352021 isoform X1 [KO:K05866] [EC:3.1.3.48]
121351874  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
121348770  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121361966  JUN; transcription factor AP-1 [KO:K04448]
121352674  JUND; transcription factor jun-D [KO:K04449]
121356463  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121356349  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
121352344  MAX; protein max [KO:K04453]
121350416  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
121361726  HSPB1; heat shock protein beta-1 [KO:K04455]
121358263  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121358719  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121349184  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
121352543  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
121360909  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
121365438  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
121365634  DUSP1; dual specificity protein phosphatase 1 isoform X1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
121360329  DUSP4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121360938  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121350346  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121351564  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121363584  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121357244  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
121351844  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
121351116  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
121358557  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
121360650  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
121353723  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
121354451  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
121349796  mitogen-activated protein kinase 7-like [KO:K04464] [EC:2.7.11.24]
121356346  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
121350568  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
121358096  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
121359273  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121357727  IKBKG; NF-kappa-B essential modulator [KO:K07210]
121361823  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
121362640  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121350054  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pruf04070  Phosphatidylinositol signaling system
pruf04110  Cell cycle
pruf04115  p53 signaling pathway
pruf04210  Apoptosis
pruf04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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