KEGG ORTHOLOGY: K04973

ORTHOLOGY: K04973

Entry

K04973                      KO

Symbol

TRPV4

Name

transient receptor potential cation channel subfamily V member 4

Pathway

map04218

Cellular senescence

map04750

Inflammatory mediator regulation of TRP channels

map05418

Fluid shear stress and atherosclerosis

Disease

H00264

Charcot-Marie-Tooth disease

H00522

Brachyolmia

H00524

Scapuloperoneal spinal muscular atrophy

H00856

Distal hereditary motor neuropathies

H01529

Avascular necrosis of femoral head

H02062

Familial digital arthropathy-brachydactyly

H02183

Parastremmatic dwarfism

H02184

Metatropic dysplasia

H02185

Spondylometaphyseal dysplasia

H02186

Spondyloepiphyseal dysplasia, Maroteaux type

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04973  TRPV4; transient receptor potential cation channel subfamily V member 4
09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04973  TRPV4; transient receptor potential cation channel subfamily V member 4
09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04973  TRPV4; transient receptor potential cation channel subfamily V member 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04973  TRPV4; transient receptor potential cation channel subfamily V member 4
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Transient receptor potential channel (TRP)
   K04973  TRPV4; transient receptor potential cation channel subfamily V member 4

Other DBs

GO:

0005262

TC:

1.A.4.2.5

Genes

HSA:	59341(TRPV4)

PTR:	452225(TRPV4)

PPS:	100983299(TRPV4)

GGO:	101136579(TRPV4)

PON:	100458589(TRPV4)

PPYG:

129010540(TRPV4)

NLE:	100590720(TRPV4)

HMH:	116479398(TRPV4)

SSYN:

129459641(TRPV4)

MCC:	709605(TRPV4)

MCF:	102116382(TRPV4)

MTHB:

126931434

MNI:	105493440(TRPV4)

CSAB:

103239092(TRPV4)

CATY:

105573214(TRPV4)

PANU:

101015622(TRPV4)

TGE:	112634530(TRPV4)

MLEU:

105552241(TRPV4)

RRO:	104674961(TRPV4)

RBB:	108534372(TRPV4)

TFN:	117089428(TRPV4)

PTEH:

111541171(TRPV4)

CANG:

105507623(TRPV4)

CJC:	100404435(TRPV4)

SBQ:	101029272(TRPV4)

CIMI:

108313348(TRPV4)

ANAN:

105728635(TRPV4)

MMUR:

105866954(TRPV4)

LCAT:

123625888(TRPV4)

PCOQ:

105823282(TRPV4)

OGA:	100962054(TRPV4)

MMU:	63873(Trpv4)

MCAL:

110294118(Trpv4)

MPAH:

110339055(Trpv4)

RNO:	66026(Trpv4)

MCOC:

116068227(Trpv4)

ANU:	117698289(Trpv4)

ASYL:

127673121(Trpv4)

MUN:	110547289(Trpv4)

CGE:	100751070(Trpv4)

MAUA:

101826031(Trpv4)

PROB:

127215968(Trpv4)

PLEU:

114681336(Trpv4)

MORG:

121446229(Trpv4)

MFOT:

126488023

AAMP:

119825176(Trpv4)

NGI:	103746703(Trpv4)

HGL:

106007498

CPOC:

100724607(Trpv4)

CCAN:

109688071(Trpv4)

DORD:

105984331(Trpv4)

DSP:	122099044(Trpv4)

DMER:

138808444 138829831

PLOP:

125349032(Trpv4)

NCAR:

124991833

MMMA:

107154634(Trpv4)

ITI:	101960739(Trpv4)

OCU:

100351058

OPI:	101525614(TRPV4)

TUP:	102481301(TRPV4)

GVR:

103582204

CFA:	486308(TRPV4)

CLUD:

112676705(TRPV4)

VVP:	112910501(TRPV4)

VLG:	121475829(TRPV4)

NPO:	129508127(TRPV4)

AML:	100472561(TRPV4)

UMR:	103678292(TRPV4)

UAH:	113267094(TRPV4)

UAR:	123788209(TRPV4)

ELK:

111156407

LLV:

125082454

MPUF:

101687241(TRPV4)

MNP:	132023266(TRPV4)

MLK:	131811259(TRPV4)

NVS:	122903318(TRPV4)

ORO:	101368028(TRPV4)

EJU:	114219127(TRPV4)

ZCA:	113913258(TRPV4)

MLX:	118018328(TRPV4)

NSU:	110592484(TRPV4)

LWW:

102735498

FCA:	101084907(TRPV4)

PYU:	121010178(TRPV4)

PCOO:

112870447(TRPV4)

PBG:	122470356(TRPV4)

PVIV:

125149588(TRPV4)

LRUF:

124518363

LGF:	123587513(TRPV4)

AJU:

106979658

PTG:	102961441(TRPV4)

PPAD:

109277466(TRPV4)

PUC:

125914043

PLEZ:

122203433(TRPV4)

HHV:	120242221(TRPV4)

BTA:	540259(TRPV4)

BOM:	102272539(TRPV4)

BIU:	109571556(TRPV4)

BBUB:

102411693(TRPV4)

BBIS:

104980203(TRPV4)

CHX:	102181145(TRPV4)

OAS:	101113534(TRPV4)

BTAX:

128062293(TRPV4)

CSUM:

138093634(TRPV4)

ODA:	120871177(TRPV4)

CCAD:

122422291(TRPV4)

MREE:

136145938(TRPV4)

OVR:	110146216(TRPV4)

MBEZ:

129542407(TRPV4)

SSC:	100126845(TRPV4)

CFR:	102515574(TRPV4)

CBAI:

105075680(TRPV4)

CDK:	105105366(TRPV4)

VPC:	102536090(TRPV4)

BACU:

103000926(TRPV4)

BMUS:

118906635(TRPV4)

LVE:	103087786(TRPV4)

OOR:	101274956(TRPV4)

LALB:

132532264(TRPV4)

GMF:	115855390(TRPV4)

DDP:	132436496(TRPV4)

DLE:	111188132(TRPV4)

PCAD:

102974511(TRPV4)

PSIU:

116738956(TRPV4)

PPHC:

136133323(TRPV4)

NASI:

112397312(TRPV4)

ECB:	100066552(TRPV4)

EPZ:	103564343(TRPV4)

EAI:	106848085(TRPV4)

MYB:	102249406(TRPV4)

MYD:	102761906(TRPV4)

MMYO:

118678394(TRPV4)

MLF:	102433459(TRPV4)

MDT:	132221647(TRPV4)

MYUM:

138997850(TRPV4)

PKL:

118725629

EFUS:

103301966(TRPV4)

MNA:	107528485(TRPV4)

DRO:	112310589(TRPV4)

SHON:

118991201(TRPV4)

AJM:	119057476(TRPV4)

PDIC:

114510103(TRPV4)

PHAS:

123823564(TRPV4)

MMF:	118639891(TRPV4)

PPAM:

129087428(TRPV4)

HAI:	109386152(TRPV4)

RFQ:	117017889(TRPV4)

PALE:

102885612(TRPV4)

PGIG:

120601888(TRPV4)

PVP:	105303963(TRPV4)

RAY:	107500137(TRPV4)

MJV:	108392445(TRPV4)

TOD:	119244875(TRPV4)

SARA:

101546657(TRPV4)

SFUM:

130023908(TRPV4)

SETR:

126000752(TRPV4)

LAV:	100666297(TRPV4)

TMU:

101359728

ETF:	101638929(TRPV4)

DNM:	101413085(TRPV4)

MDO:	100028359(TRPV4) 103099983

GAS:

123245256

SHR:	100928433(TRPV4)

AFZ:

127545603

PCW:	110203574(TRPV4)

TVP:	118833447(TRPV4)

PBRV:

138156158(TRPV4)

MLAO:

141501806(TRPV4)

OAA:	100081229(TRPV4)

TACU:

119942279(TRPV4)

GGA:	395427(TRPV4)

PCOC:

116228537(TRPV4)

MGP:	100539676(TRPV4)

CJO:	107321526(TRPV4)

TPAI:

128084762(TRPV4)

LMUT:

125701668(TRPV4)

NMEL:

110406616(TRPV4)

APLA:

119718581(TRPV4)

ACYG:

106031392(TRPV4)

CATA:

118257627(TRPV4)

AFUL:

116496253(TRPV4)

TGU:	100220808(TRPV4)

LSR:	110478111(TRPV4)

SCAN:

103818122(TRPV4)

PMOA:

120509762(TRPV4)

OTC:	121338994(TRPV4)

PRUF:

121365054(TRPV4)

ATRC:

139598628(TRPV4)

GFR:	102037485(TRPV4)

FAB:	101816528(TRPV4)

OMA:	130259543(TRPV4)

PHI:	102106437(TRPV4)

PMAJ:

107211489(TRPV4)

CCAE:

111936724(TRPV4)

CCW:	104688805(TRPV4)

CBRC:

103616072(TRPV4)

ACOE:

138119343(TRPV4)

ETL:	114062675(TRPV4)

ZAB:	102071730(TRPV4)

ZLE:	135454541(TRPV4)

ACHL:

103808942(TRPV4)

SVG:	106852336(TRPV4)

MMEA:

130580526(TRPV4)

HRT:	120760512(TRPV4)

SATI:

136368981(TRPV4)

CCIC:

134050911(TRPV4)

FPG:	101924616(TRPV4)

FCH:	102051043(TRPV4)

SHAB:

115614353(TRPV4)

TALA:

116962090(TRPV4)

ACHC:

115345751(TRPV4)

HLE:	104840831(TRPV4)

AGEN:

126040650

HHAR:

128146557(TRPV4)

GCL:

127023072

CSTI:

104556238(TRPV4)

LDI:	104347102(TRPV4)

DPUB:

104308510(TRPV4)

PPUS:

135188627(TRPV4)

EGZ:	104128379(TRPV4)

NNI:	104019088(TRPV4)

PCRI:

104028461(TRPV4)

PADL:

103925688(TRPV4)

AFOR:

103902750(TRPV4)

CBOY:

140660076(TRPV4)

CLV:	102093421(TRPV4)

CNIC:

135995187(TRPV4)

MUI:	104539841(TRPV4)

CUCA:

104058912(TRPV4)

CPEA:

104388042(TRPV4)

CVF:	104282297(TRPV4)

RTD:	128917084(TRPV4)

CRID:

134523044(TRPV4)

AAM:	106484376(TRPV4)

AROW:

112963338(TRPV4)

NPD:	112945183(TRPV4)

DNE:	112991780(TRPV4)

ASN:	102383407(TRPV4)

AMJ:	102560425(TRPV4)

CPOO:

109312611(TRPV4)

GGN:	109290612(TRPV4)

PSS:	102444313(TRPV4)

CMY:	102944289(TRPV4)

CCAY:

125623035(TRPV4)

DCC:	119843909(TRPV4)

CPIC:

101936738(TRPV4)

TST:	117888263(TRPV4)

CABI:

116839461(TRPV4)

MRV:	120386398(TRPV4)

ASAO:

132781467(TRPV4)

PVT:	110083439(TRPV4)

PBI:	103048820(TRPV4)

PMUR:

107287302(TRPV4)

CTIG:

120316793(TRPV4)

TSR:	106556829(TRPV4)

PGUT:

117672296(TRPV4) 132711941

PCAE:

139322361(TRPV4)

APRI:

131185737(TRPV4)

PTEX:

113448587(TRPV4)

NSS:	113423910(TRPV4)

VKO:	123028533(TRPV4)

PMUA:

114582661(TRPV4)

PRAF:

128400212(TRPV4)

ZVI:	118094439(TRPV4)

HCG:	128338205(TRPV4)

GJA:	107112156(TRPV4)

STOW:

125442515(TRPV4)

EMC:	129341578(TRPV4)

XLA:	108707078(trpv4.S) 108715661(trpv4.L) 108719392(trpv4l.2.L) 108719393(trpv4l.1.L)

XTR:	100494183(trpv4l.4) 100494341(trpv4l.3) 100494502(trpv4l.2) 100494662(trpv4l.1) 100494817 100496204(trpv4)

NPR:	108790660(TRPV4)

RTEM:

120938014(TRPV4)

ACAT:

141144223(TRPV4)

BBUF:

120988850(TRPV4)

BGAR:

122933759(TRPV4)

DTC:	141096177(TRPV4)

PWL:	138266218(TRPV4)

MUO:	115480603(TRPV4)

GSH:	117366138(TRPV4)

DRE:	557850(trpv4)

SRX:	107741238 107752140

SANH:

107654595 107672638

SGH:	107595959 107597337(trpv4)

CCAR:

109082954 109090369

CAUA:

113048910 113048997 113096063

CGIB:

127958769 128013057

PTET:

122345491(trpv4)

LROH:

127165626(trpv4)

GRF:	141334546(trpv4)

OMC:	131541476(trpv4)

PPRM:

120470292(trpv4)

RKG:	130097135(trpv4)

MAMB:

125267203(trpv4)

CIDE:

127513360

CERY:

137033567(trpv4)

MASI:

127418579 127434669

TROS:

130545547(trpv4)

TDW:	130420020(trpv4)

MANU:

129439829(trpv4)

PDAB:

135732574(trpv4)

IPU:

108255555

IFU:	128599187(trpv4)

PHYP:

113524978(trpv4)

SMEO:

124380936(trpv4)

TFD:	113647463(trpv4)

TVC:	132855069(trpv4)

CGAR:

128509168(trpv4)

NGRA:

132872778(trpv4)

TRN:	134335273(trpv4)

AMEX:

103044256(trpv4)

CMAO:

118827769(trpv4)

EEE:	113588115(trpv4)

CHAR:

105902873(trpv4)

SPIL:

134088716(trpv4)

TRU:	101076379(trpv4)

TFS:	130525585(trpv4)

TNG:	GSTEN00029525G001

LCO:	104921258(trpv4)

NCC:	104945022(trpv4)

TBEN:

117475959(trpv4)

CGOB:

115013508(trpv4)

PGEO:

117451902(trpv4)

GACU:

117535767(trpv4)

EMAC:

134873022(trpv4)

ELY:	117251890(trpv4)

EFO:	125890767(trpv4)

PLEP:

121944824(trpv4)

SLUC:

116056753(trpv4)

ECRA:

117945113(trpv4)

ESP:	116689730(trpv4)

PFLV:

114555476(trpv4)

GAT:	120831132(trpv4)

PPUG:

119225629(trpv4)

AFB:	129100989(trpv4)

CLUM:

117736243(trpv4)

PSWI:

130196570(trpv4)

CANA:

137805205(trpv4)

CVE:	137867310(trpv4)

MSAM:

119891968(trpv4)

SCHU:

122876487(trpv4)

CUD:	121509874(trpv4)

SPUL:

138610270(trpv4)

LMIX:

132974226(trpv4)

ALAT:

119020004(trpv4)

ASTR:

137593048(trpv4)

MZE:	101480550(trpv4)

ONL:	100708918(trpv4)

OAU:	116332470(trpv4)

OLA:	101169862(trpv4)

OML:	112148927(trpv4)

CSAI:

133450472(trpv4)

XMA:	102230730(trpv4)

XCO:	114154457(trpv4)

XHE:	116729572(trpv4)

PRET:

103470336(trpv4)

PFOR:

103142885(trpv4)

PLAI:

106944547(trpv4)

PMEI:

106918364(trpv4)

GAF:	122828270(trpv4)

PPRL:

129372170(trpv4)

CVG:	107097274(trpv4)

CTUL:

119786621(trpv4)

GMU:	124877230(trpv4)

NFU:	107393966(trpv4)

KMR:	108234642(trpv4)

ALIM:

106521703(trpv4)

NWH:	119413384(trpv4)

EJA:	138191883(trpv4)

BFRE:

138627284(trpv4)

MCEP:

125012134(trpv4)

CSEM:

103397316(trpv4)

POV:	109638077(trpv4)

SSEN:

122769154(trpv4)

SSOE:

131463396(trpv4)

HHIP:

117767680(trpv4)

HSP:	118115642(trpv4)

PPLT:

128439006(trpv4)

SMAU:

118314456(trpv4)

LCF:

108878773

SDU:	111230474(trpv4)

SLAL:

111660386(trpv4)

XGL:	120804673(trpv4)

HCQ:	109510178(trpv4)

SSCV:

125993561(trpv4)

SBIA:

133499240(trpv4)

PEE:	133400530(trpv4)

PTAO:

133475417(trpv4)

BPEC:

110156682(trpv4)

ENY:	140346903(trpv4)

MALB:

109956865(trpv4)

BSPL:

114862173(trpv4)

SJO:	128364654(trpv4)

SSCO:

133978878(trpv4)

GMH:

115554561

SASA:

106580102(trpv4) 106585668(TRPV4)

STRU:

115164852 115199811(trpv4)

OTW:	112248245 112263282(trpv4)

OMY:	110525364 110535765

OGO:	124034557 124036047(trpv4)

ONE:	115111338 115139770

OKI:	109876300 109895664(trpv4)

OKE:	118358065 118392940

OMM:	135514348(trpv4) 135525853

OCLA:

139389913 139410688

SALP:

111957978 111974837

SNH:	120054037 120062681

CCLU:

121551194 121584531

ELS:	105014442(trpv4)

OEP:	134014924(trpv4)

SFM:	108932506(trpv4)

PKI:	111854916(trpv4)

AANG:

118237084(trpv4)

AROT:

135264726(trpv4)

CCOG:

133140293(trpv4)

LOC:	102694383(trpv4)

PSPA:

121296798 121307692

ARUT:

117426616 117428023

PSEX:

120540749(trpv4)

LCM:	102362597(TRPV4)

CMK:	103184030(trpv4)

RTP:	109914855(trpv4)

CPLA:

122562564

HOC:	132827059(trpv4)

LERI:

129709183(trpv4)

HAKA:

140738499(trpv4)

AIRR:

LAK:

ATEN:

SPIS:

DGT:

XEN:

Reference

PMID:11081638

Authors

Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S

Title

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.

Journal

Cell 103:525-35 (2000)
DOI:10.1016/S0092-8674(00)00143-4

Sequence

[rno:66026]

LinkDB

DBGET integrated database retrieval system