KEGG ORTHOLOGY: K04126

ORTHOLOGY: K04126

Entry

K04126                      KO

Symbol

PCBC

Name

isopenicillin-N synthase [EC:1.21.3.1]

Pathway

map00311

Penicillin and cephalosporin biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00672

Penicillin biosynthesis, aminoadipate + cycteine + valine => penicillin

M00673

Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K04126  PCBC; isopenicillin-N synthase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K04126  PCBC; isopenicillin-N synthase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.21  Catalysing the reaction X-H + Y-H = X-Y
   1.21.3  With oxygen as acceptor
    1.21.3.1  isopenicillin-N synthase
     K04126  PCBC; isopenicillin-N synthase
Polyketide biosynthesis proteins [BR:ko01008]
Nonribosomal peptide tailoring proteins
  Others
   K04126  PCBC; isopenicillin-N synthase

Other DBs

RN:

R04872

GO:

0016216

Genes

BCOO:

119077147

FCD:

110843583

ANI:

AN2622.2

AOR:	AO090038000544

AFV:	AFLA_009030

APUU:

APUU_12363A

PCS:	Pc21g21380(ips)

ABE:

ARB_02225

TVE:

TRV_00552

SCT:	SCAT_5683(pcbC)

SCY:	SCATT_56830

SCLF:

BB341_07795

STIR:

DDW44_23090

AAB:	A4R43_03225

AMYY:

YIM_39180(cefE1)

PSUU:

Psuf_059690

» show all

Reference

PMID:7791906

Authors

Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE

Title

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.

Journal

Nature 375:700-4 (1995)
DOI:10.1038/375700a0

Sequence

[ani:AN2622.2]

LinkDB

ENZYME: 1.21.3.1

Entry

EC 1.21.3.1                 Enzyme

Name

isopenicillin-N synthase;
isopenicillin N synthetase

Class

Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor

Sysname

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)

Reaction(IUBMB)

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O

Reaction(KEGG)

(other) R04872

Substrate

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine;
O2 [CPD:C00007]

Product

isopenicillin N [CPD:C05557];
H2O [CPD:C00001]

Comment

Forms part of the penicillin biosynthesis pathway (for pathway, click here).

History

EC 1.21.3.1 created 2002

Pathway

ec00311

Penicillin and cephalosporin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K04126

isopenicillin-N synthase

Genes

BCOO:

119077147

FCD:

110843583

ANI:

AN2622.2

AOR:	AO090038000544

AFV:	AFLA_009030

APUU:

APUU_12363A

PCS:	Pc21g21380(ips)

ABE:

ARB_02225

TVE:

TRV_00552

SCT:	SCAT_5683(pcbC)

SCY:	SCATT_56830

SCLF:

BB341_07795

STIR:

DDW44_23090

AAB:	A4R43_03225

AMYY:

YIM_39180(cefE1)

PSUU:

Psuf_059690

» show all

Reference

1 [PMID:1588566]

Authors

Huffman GW, Gesellchen PD, Turner JR, Rothenberger RB, Osborne HE, Miller FD, Chapman JL, Queener SW.

Title

Substrate specificity of isopenicillin N synthase.

Journal

J Med Chem 35:1897-914 (1992)
DOI:10.1021/jm00088a028

Reference

2 [PMID:7791906]

Authors

Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE

Title

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.

Journal

Nature 375:700-4 (1995)
DOI:10.1038/375700a0

Sequence

[ani:AN2622.2]

Other DBs

ExplorEnz - The Enzyme Database:

1.21.3.1

IUBMB Enzyme Nomenclature:

1.21.3.1

ExPASy - ENZYME nomenclature database:

1.21.3.1

BRENDA, the Enzyme Database:

1.21.3.1

CAS:	78642-31-6

LinkDB

REACTION: R04872

Entry

R04872                      Reaction

Definition

delta-(L-2-Aminoadipyl)-L-cysteinyl-D-valine + Oxygen <=> Isopenicillin N + 2 H2O

Equation

C05556 + C00007 <=> C05557 + 2 C00001

Comment

multi-step reaction

Reaction class

RC01229

C05556_C05557

Enzyme

1.21.3.1

Pathway

rn00311

Penicillin and cephalosporin biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00672

Penicillin biosynthesis, aminoadipate + cycteine + valine => penicillin

M00673

Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C

Orthology

K04126

isopenicillin-N synthase [EC:1.21.3.1]

Other DBs

RHEA:

22431

LinkDB

DBGET integrated database retrieval system