KEGG   ORTHOLOGY: K07210
Entry
K07210                      KO                                     

Symbol
IKBKG, IKKG, NEMO
Name
inhibitor of nuclear factor kappa-B kinase subunit gamma
Pathway
map01523  Antifolate resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04668  TNF signaling pathway
map04920  Adipocytokine signaling pathway
map04936  Alcoholic liver disease
map05010  Alzheimer disease
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05142  Chagas disease
map05145  Toxoplasmosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05208  Chemical carcinogenesis - reactive oxygen species
map05212  Pancreatic cancer
map05215  Prostate cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05222  Small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05340  Primary immunodeficiency
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00089  IFN-gamma/IL-12 axis
H00095  Ectodermal dysplasia associated immunodeficiency
H00540  Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID)
H00645  Incontinentia pigmenti
H01245  Immunodeficiency without anhidrotic ectodermal dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04014 Ras signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04064 NF-kappa B signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04668 TNF signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04151 PI3K-Akt signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04621 NOD-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04622 RIG-I-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04623 Cytosolic DNA-sensing pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04625 C-type lectin receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04660 T cell receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04658 Th1 and Th2 cell differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04659 Th17 cell differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04657 IL-17 signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04662 B cell receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04062 Chemokine signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05208 Chemical carcinogenesis - reactive oxygen species
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05203 Viral carcinogenesis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05221 Acute myeloid leukemia
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05220 Chronic myeloid leukemia
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05215 Prostate cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05222 Small cell lung cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05170 Human immunodeficiency virus 1 infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05161 Hepatitis B
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05160 Hepatitis C
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05171 Coronavirus disease - COVID-19
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05164 Influenza A
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05162 Measles
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05168 Herpes simplex virus 1 infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05163 Human cytomegalovirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05169 Epstein-Barr virus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05165 Human papillomavirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05130 Pathogenic Escherichia coli infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05132 Salmonella infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05131 Shigellosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05135 Yersinia infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05142 Chagas disease
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09163 Immune disease
   05340 Primary immunodeficiency
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05418 Fluid shear stress and atherosclerosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
Genes
HSA: 8517(IKBKG)
PTR: 100609537(IKBKG) 100610002
PPS: 100987483(IKBKG)
GGO: 101145841(IKBKG) 115932121
PON: 100449496(IKBKG)
NLE: 100603768(IKBKG)
MCC: 701237(IKBKG)
MCF: 102115368(IKBKG)
CSAB: 103232832(IKBKG)
CATY: 105573773(IKBKG)
RRO: 104667046(IKBKG)
RBB: 108518784(IKBKG)
TFN: 117078341(IKBKG)
CJC: 100390258(IKBKG)
SBQ: 101043425(IKBKG)
MMUR: 105867816(IKBKG)
MMU: 16151(Ikbkg)
MCAL: 110287188(Ikbkg)
MPAH: 110313464(Ikbkg)
RNO: 309295(Ikbkg)
MCOC: 116086280(Ikbkg)
MUN: 110562528(Ikbkg)
CGE: 100759762(Ikbkg)
PLEU: 114706175(Ikbkg)
NGI: 103731232(Ikbkg)
HGL: 101712077(Ikbkg)
CCAN: 109691919(Ikbkg)
OCU: 100328905(IKBKG)
TUP: 102476758(IKBKG)
VVP: 112911512(IKBKG)
VLG: 121482779(IKBKG)
AML: 100470223(IKBKG)
UMR: 103679680(IKBKG)
UAH: 113247832(IKBKG)
ORO: 101384959(IKBKG)
ELK: 111139191
MPUF: 101671648(IKBKG)
EJU: 114203804(IKBKG)
MLX: 118014480(IKBKG)
FCA: 101086544(IKBKG)
PYU: 121025049(IKBKG)
PPAD: 109261148(IKBKG) 109261721
AJU: 106988817(IKBKG)
HHV: 120226622(IKBKG)
BTA: 281855(IKBKG)
BOM: 102287968(IKBKG)
BBUB: 102394706(IKBKG)
CHX: 102171591(IKBKG)
OAS: 101107332(IKBKG)
ODA: 120881825(IKBKG)
CCAD: 122434540(IKBKG)
SSC: 100127355(IKBKG)
CFR: 102519782(IKBKG)
CBAI: 105076053(IKBKG) 105076396
CDK: 105106603(IKBKG)
BACU: 103017855
LVE: 103074882(IKBKG)
OOR: 101272428(IKBKG)
DLE: 111170969(IKBKG)
PCAD: 102980964(IKBKG) 114485485
ECB: 100058432(IKBKG)
EPZ: 103543979
EAI: 106828814(IKBKG)
MYB: 102252013(IKBKG)
MYD: 102772051(IKBKG)
MMYO: 118653690(IKBKG)
MNA: 107544156(IKBKG)
HAI: 109377344(IKBKG)
DRO: 112296261(IKBKG)
SHON: 118994325(IKBKG)
AJM: 119053789(IKBKG)
MMF: 118635619(IKBKG)
PALE: 102880203(IKBKG)
PGIG: 120605919(IKBKG)
RAY: 107499585(IKBKG)
MJV: 108400819(IKBKG)
TOD: 119245781(IKBKG)
LAV: 100661492(IKBKG)
TMU: 101347574
MDO: 100022918(IKBKG)
SHR: 100926701(IKBKG)
PCW: 110200334(IKBKG)
OAA: 100073613(IKBKG)
TGU: 115491960(IKBKG)
PMOA: 120504128(IKBKG)
FAB: 101821038
PHI: 102113899(IKBKG)
PMAJ: 107198881(IKBKG)
CCAE: 111942179(IKBKG)
CCW: 120412233(IKBKG)
ASN: 102374662(IKBKG)
AMJ: 102561500(IKBKG)
PSS: 102445093(IKBKG)
CMY: 102938812(IKBKG)
CPIC: 101942490(IKBKG)
CABI: 116823432(IKBKG)
ACS: 100567119(ikbkg)
PVT: 110089205(IKBKG)
PBI: 103053675(IKBKG)
PMUR: 107284206(IKBKG)
PGUT: 117675545(IKBKG)
PMUA: 114588195(IKBKG)
ZVI: 118078861(IKBKG)
GJA: 107114301
XLA: 735069(ikbkg.L)
XTR: 100145270(ikbkg)
NPR: 108791352(IKBKG)
DRE: 541530(ikbkg)
IPU: 108275953(ikbkg)
PHYP: 113530655(ikbkg)
AMEX: 103043929(ikbkg)
EEE: 113587986(ikbkg)
TRU: 101069645
LCO: 104933745(ikbkg)
CGOB: 115010596(ikbkg)
ELY: 117258475(ikbkg)
SLUC: 116040658(ikbkg)
ECRA: 117947160(ikbkg)
PFLV: 114558815(ikbkg)
GAT: 100174893(ikbkg)
CUD: 121517148(ikbkg)
MZE: 101466977(ikbkg)
ONL: 100703664(ikbkg)
OAU: 116325151(ikbkg)
OLA: 101162681(ikbkg)
OML: 112158682(ikbkg)
XMA: 102233509(ikbkg)
XCO: 114140444(ikbkg)
XHE: 116724200(ikbkg)
PRET: 103466941(ikbkg)
CVG: 107093789
CTUL: 119775467(ikbkg)
NFU: 107391543(ikbkg)
KMR: 108249185(ikbkg)
ALIM: 106523021(ikbkg)
AOCE: 111582017
CSEM: 103384713(ikbkg)
POV: 109630748(ikbkg)
SDU: 111236982(ikbkg)
SLAL: 111659926(ikbkg)
XGL: 120803427(ikbkg)
HCQ: 109528595(ikbkg)
BPEC: 110162114(ikbkg)
MALB: 109969980
OMY: 110492712(ikbkg) 110532862
SALP: 112072968
SNH: 120039965 120061717(ikbkg)
ELS: 105030753(ikbkg)
PKI: 111837508(ikbkg) 111855295
AANG: 118210597(ikbkg)
LOC: 102682818
PSPA: 121329109(ikbkg)
LCM: 102351908(IKBKG)
CIN: 100184680
CCAT: 101450516
ACER: 108001133
CCIN: 107264943
AGB: 108908243
BANY: 112047048
RSAN: 119387644
RMP: 119159779
GAE: 121390333
PMAX: 117331878
 » show all
Reference
PMID:9751060
  Authors
Rothwarf DM, Zandi E, Natoli G, Karin M
  Title
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
  Journal
Nature 395:297-300 (1998)
DOI:10.1038/26261
  Sequence
[hsa:8517]
Reference
  Authors
Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM
  Title
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.
  Journal
Nature 427:167-71 (2004)
DOI:10.1038/nature02273
LinkDB

DBGET integrated database retrieval system