KEGG   ORTHOLOGY: K22101
Entry
K22101                      KO                                     

Name
PTPS
Definition
dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase [EC:4.1.2.60 4.2.3.12]
Pathway
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K22101  PTPS; dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.60  dihydroneopterin triphosphate aldolase
     K22101  PTPS; dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.12  6-pyruvoyltetrahydropterin synthase
     K22101  PTPS; dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase
Other DBs
RN: R04286 R11719
Genes
PFA: PF3D7_0628000
PFD: PFDG_00795
PFH: PFHG_00633
PYO: PY17X_1128200
PCB: PCHAS_112620(PC000014.00.0)
PBE: PBANKA_1126700
PKN: PKNH_1121800
PVX: PVX_114505
PCY: PCYB_113000
PTI: PHATRDRAFT_50741
SPAR: SPRG_04534
 » show all
Reference
  Authors
Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, Sims PF, Hyde JE
  Title
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.
  Journal
Mol Microbiol 67:609-18 (2008)
DOI:10.1111/j.1365-2958.2007.06073.x
  Sequence
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