| Entry |
|
|---|
| Symbol |
PTPS
|
|---|
| Name |
dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase [EC: 4.1.2.60 4.2.3.12]
|
|---|
| Pathway |
|
|---|
| Module |
| M00841 | Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF |
|
|---|
| Reaction |
| R04286 | 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate lyase |
| R11719 | 7,8-dihydroneopterin-3'-triphosphate glycolaldehyde-phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming] |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
K22101 PTPS; dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase
Enzymes [BR:ko01000]
4. Lyases
4.1 Carbon-carbon lyases
4.1.2 Aldehyde-lyases
4.1.2.60 dihydroneopterin triphosphate aldolase
K22101 PTPS; dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase
4.2 Carbon-oxygen lyases
4.2.3 Acting on phosphates
4.2.3.12 6-pyruvoyltetrahydropterin synthase
K22101 PTPS; dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, Sims PF, Hyde JE |
|---|
| Title |
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| LinkDB |
|
|---|
