KEGG   MODULE: M00009
Entry
M00009            Pathway   Module                                 
Name
Citrate cycle (TCA cycle, Krebs cycle)
Definition
(K01647,K05942,K01659) (K01681,K27802,K01682) (K00031,K00030) ((K00164+K00658,K01616)+K00382,K00174+K00175-K00177-K00176) (K01902+K01903,K01899+K01900,K18118) (K00234+K00235+K00236+(K00237,K25801),K00239+K00240+K00241-(K00242,K18859,K18860),K00244+K00245+K00246-K00247) (K01676,K01679,K01677+K01678) (K00026,K00025,K00024,K00116)
Diagram
M00009

Orthology
K01647  
citrate synthase [EC:2.3.3.1] [RN:R00351]
K05942  
citrate (Re)-synthase [EC:2.3.3.3] [RN:R00351]
K01659  
2-methylcitrate synthase [EC:2.3.3.5] [RN:R00351]
K01681,K27802,K01682  
aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900 R01324]
K00031,K00030  
isocitrate dehydrogenase [EC:1.1.1.42 1.1.1.41] [RN:R01899 R00268 R00267 R00709]
K00164,K01616,K00658,K00382  
2-oxoglutarate dehydrogenase complex [EC:1.2.4.2 2.3.1.61 1.8.1.4] [RN:R00621 R03316 R01700 R02570 R07618]
K00174  
2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] [RN:R01197]
K00175  
2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] [RN:R01197]
K00177  
2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] [RN:R01197]
K00176  
2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] [RN:R01197]
K01902,K01903  
succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
K01899,K01900  
succinyl-CoA synthetase [EC:6.2.1.4 6.2.1.5] [RN:R00405 R00432 R00727]
K18118  
succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] [RN:R10343]
K00234,K00235,K00236,K00237,K25801  
succinate dehydrogenase [EC:1.3.5.1] [RN:R02164]
K00239,K00240,K00241,K00242,K18859,K18860  
succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164]
K00244,K00245,K00246,K00247 fumarate reductase [EC:1.3.5.4] [RN:R02164]  
 
K01676,K01679,K01677,K01678  
fumarate hydratase [EC:4.2.1.2] [RN:R01082]
K00026,K00025,K00024  
malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
K00116  
malate dehydrogenase (quinone) [EC:1.1.5.4] [RN:R00361]
Class
Pathway modules; Carbohydrate metabolism; Central carbohydrate metabolism
Pathway
map00020  Citrate cycle (TCA cycle)
map01200  Carbon metabolism
map01100  Metabolic pathways
Reaction
R00351  
R01325+R01900,R01324  
R01899+R00268,R00267,R00709  
R00621+R03316,R01700  
R02570  
R07618  
R01197  
R00405,R00432,R00727,R10343  
R02164  
R01082  
R00342,R00361  
Compound
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00158  Citrate
C00311  Isocitrate
C00026  2-Oxoglutarate
C15972  Enzyme N6-(lipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C00091  Succinyl-CoA
C15973  Enzyme N6-(dihydrolipoyl)lysine
C00042  Succinate
C00122  Fumarate
C00149  (S)-Malate
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