Entry |
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Name |
Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
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Definition |
K02078
K11263+K18472 K00645 K11608
K11609+K11610+K27071+K27072+K11611 K27070+K11610+K27072+(K27073,K27074)+K11611
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Diagram |
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Orthology |
acpM; acyl carrier protein accA3; acetyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC: 6.4.1.2 6.3.4.14] [RN: R00742] fabD; [acyl-carrier-protein] S-malonyltransferase [EC: 2.3.1.39] [RN: R01626] mtfabH; mycobacterial beta-ketoacyl-[acyl-carrier protein] synthase III [EC: 2.3.1.301] [RN: R13257] hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-] [RN: R13260 R13264 R13268] hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-] [RN: R13260 R13264 R13268 R13272] kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II [EC: 2.3.1.294] [RN: R13270] hadC; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadC [EC:4.2.1.-] [RN: R13272] hadD; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadD [EC:4.2.1.-] [RN: R13272] |
Class |
Pathway modules; Lipid metabolism; Fatty acid metabolism
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Pathway |
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Reaction |
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Compound |
C01209 | Malonyl-[acyl-carrier protein] |
C22858 | Long-chain 3-oxoacyl-[acyl-carrier protein] |
C20683 | Long-chain acyl-[acyl-carrier protein] |
C22859 | Long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] |
C22860 | Long-chain trans-2-enoyl-[acyl-carrier protein] |
C22861 | Very-long-chain acyl-[acyl-carrier protein] |
C22862 | Very-long-chain 3-oxoacyl-[acyl-carrier protein] |
C22863 | Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] |
C22864 | Very-long-chain trans-2-enoyl-[acyl-carrier protein] |
C22865 | Ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] |
C22866 | Ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] |
C22867 | Ultra-long-chain mono-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] |
C22868 | Ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein] |
C22869 | Ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] |
C22870 | Ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] |
C22871 | Ultra-long-chain di-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] |
C22872 | Ultra-long-chain di-unsaturated trans-2-enoyl-[acyl-carrier protein] |
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RModule |
RM021 | Fatty acid synthesis using malonyl-CoA |
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Reference |
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Authors |
Takayama K, Wang C, Besra GS. |
Title |
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. |
Journal |
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Reference |
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Authors |
Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H. |
Title |
Fatty acid biosynthesis in actinomycetes. |
Journal |
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Reference |
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Authors |
Marrakchi H, Laneelle MA, Daffe M. |
Title |
Mycolic acids: structures, biosynthesis, and beyond. |
Journal |
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Reference |
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Authors |
Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D. |
Title |
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes. |
Journal |
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Reference |
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Authors |
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A |
Title |
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. |
Journal |
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LinkDB |
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