KEGG   MODULE: M00886
Entry
M00886            Pathway   Module                                 
Name
Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
Definition
K02078
K11263+K18472 K00645 K11608
K11609+K11610+K27071+K27072+K11611 K27070+K11610+K27072+(K27073,K27074)+K11611
Diagram
M00886

Orthology
K02078  
acpM; acyl carrier protein
K11263  
accA3; acetyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.3.4.14] [RN:R00742]
K18472  
accD6; acetyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 2.1.3.15] [RN:R00742]
K00645  
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] [RN:R01626]
K11608  
mtfabH; mycobacterial beta-ketoacyl-[acyl-carrier protein] synthase III [EC:2.3.1.301] [RN:R13257]
K11609  
kasA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase I [EC:2.3.1.293] [RN:R13258 R13262 R13266]
K11610  
mabA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-] [RN:R13259 R13263 R13267 R13271]
K27071  
hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-] [RN:R13260 R13264 R13268]
K27072  
hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-] [RN:R13260 R13264 R13268 R13272]
K11611  
inhA; meromycolic acid enoyl-[acyl-carrier protein] reductase [EC:1.3.1.118] [RN:R13261 R13265 R13269 R13273]
K27070  
kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II [EC:2.3.1.294] [RN:R13270]
K27073  
hadC; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadC [EC:4.2.1.-] [RN:R13272]
K27074  
hadD; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadD [EC:4.2.1.-] [RN:R13272]
Class
Pathway modules; Lipid metabolism; Fatty acid metabolism
Pathway
map00074  Mycolic acid biosynthesis
Reaction
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00229  Acyl-carrier protein
C01209  Malonyl-[acyl-carrier protein]
C02843  Long-chain acyl-CoA
C22858  Long-chain 3-oxoacyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C22859  Long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein]
C22860  Long-chain trans-2-enoyl-[acyl-carrier protein]
C22861  Very-long-chain acyl-[acyl-carrier protein]
C22862  Very-long-chain 3-oxoacyl-[acyl-carrier protein]
C22863  Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein]
C22864  Very-long-chain trans-2-enoyl-[acyl-carrier protein]
C22865  Ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein]
C22866  Ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein]
C22867  Ultra-long-chain mono-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein]
C22868  Ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein]
C22869  Ultra-long-chain di-unsaturated acyl-[acyl-carrier protein]
C22870  Ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein]
C22871  Ultra-long-chain di-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein]
C22872  Ultra-long-chain di-unsaturated trans-2-enoyl-[acyl-carrier protein]
RModule
RM021  Fatty acid synthesis using malonyl-CoA
Reference
  Authors
Takayama K, Wang C, Besra GS.
  Title
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 18:81-101 (2005)
DOI:10.1128/CMR.18.1.81-101.2005
Reference
  Authors
Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H.
  Title
Fatty acid biosynthesis in actinomycetes.
  Journal
FEMS Microbiol Rev 35:475-97 (2011)
DOI:10.1111/j.1574-6976.2010.00259.x
Reference
  Authors
Marrakchi H, Laneelle MA, Daffe M.
  Title
Mycolic acids: structures, biosynthesis, and beyond.
  Journal
Chem Biol 21:67-85 (2014)
DOI:10.1016/j.chembiol.2013.11.011
Reference
  Authors
Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D.
  Title
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define  the specificity of the mycolic acid elongation complexes.
  Journal
PLoS One 6:e29564 (2011)
DOI:10.1371/journal.pone.0029564
Reference
  Authors
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A
  Title
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104
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