| Entry |
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| Name |
Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)
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| Definition |
K02078
(K11263+K18472 K00645) K11608
(K11609+K11610+K27071+K27072+K11611) (K27070+K11610+K27072+(K27073,K27074)+K11611)
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| Diagram |
| M00886 | Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB) |
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| Class |
Pathway modules; Lipid metabolism; Fatty acid metabolism
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| Pathway |
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| Orthology |
acpM; acyl carrier protein accA3; acetyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC: 6.4.1.2 6.3.4.14] [RN: R00742] fabD; [acyl-carrier-protein] S-malonyltransferase [EC: 2.3.1.39] [RN: R01626] mtfabH; mycobacterial beta-ketoacyl-[acyl-carrier protein] synthase III [EC: 2.3.1.301] [RN: R13257] hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadA [EC:4.2.1.-] [RN: R13260 R13264 R13268] hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadB [EC:4.2.1.-] [RN: R13260 R13264 R13268 R13272] kasB; meromycolic acid 3-oxoacyl-[acyl-carrier protein] synthase II [EC: 2.3.1.294] [RN: R13270] hadC; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadC [EC:4.2.1.-] [RN: R13272] hadD; meromycolic acid (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase HadD [EC:4.2.1.-] [RN: R13272] |
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| Complete |
| mtu | Mycobacterium tuberculosis H37Rv |
| mtv | Mycobacterium tuberculosis H37Rv |
| mtc | Mycobacterium tuberculosis CDC1551 |
| mra | Mycobacterium tuberculosis H37Ra |
| mtf | Mycobacterium tuberculosis F11 |
| mtb | Mycobacterium tuberculosis KZN 1435 |
| mtk | Mycobacterium tuberculosis KZN 4207 |
| mtz | Mycobacterium tuberculosis KZN 605 |
| mtur | Mycobacterium tuberculosis CCDC5079 |
| mto | Mycobacterium tuberculosis CTRI-2 |
| mtd | Mycobacterium tuberculosis UT205 |
| mtj | Mycobacterium tuberculosis Beijing/NITR203 |
| mtub | Mycobacterium tuberculosis 7199-99 |
| mtx | Mycobacterium tuberculosis EAI5 |
| mtul | Mycobacterium tuberculosis Haarlem |
| mtut | Mycobacterium tuberculosis BT1 |
| mtuu | Mycobacterium tuberculosis BT2 |
| mtq | Mycobacterium tuberculosis HKBS1 |
| mbo | Mycobacterium tuberculosis variant bovis AF2122/97 |
| mbb | Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2 |
| mbt | Mycobacterium tuberculosis variant bovis BCG Tokyo 172 |
| mbm | Mycobacterium tuberculosis variant bovis BCG Mexico |
| mbk | Mycobacterium tuberculosis variant bovis BCG Korea 1168P |
| mbx | Mycobacterium tuberculosis variant bovis BCG ATCC 35743 |
| maf | Mycobacterium tuberculosis variant africanum |
| mmic | Mycobacterium tuberculosis variant microti |
| mce | Mycobacterium canettii CIPT 140010059 |
| mcq | Mycobacterium canettii CIPT 140060008 |
| mcv | Mycobacterium canettii CIPT 140070008 |
| mcx | Mycobacterium canettii CIPT 140070010 |
| mcz | Mycobacterium canettii CIPT 140070017 |
| mory | Mycobacterium orygis |
| mpa | Mycobacterium avium subsp. paratuberculosis K-10 |
| mao | Mycobacterium avium subsp. paratuberculosis MAP4 |
| mavi | Mycobacterium avium subsp. paratuberculosis E1 |
| mavu | Mycobacterium avium subsp. paratuberculosis E93 |
| mav | Mycobacterium avium 104 |
| mavm | Mycobacterium avium subsp. avium |
| mit | Mycobacterium intracellulare MOTT-02 |
| mia | Mycobacterium intracellulare ATCC 13950 |
| mid | Mycobacterium intracellulare subsp. intracellulare |
| myo | Mycobacterium intracellulare subsp. yongonense |
| mchi | Mycobacterium intracellulare subsp. chimaera |
| mir | Mycobacterium paraintracellulare |
| mmal | Mycobacterium marseillense |
| mlp | Mycobacterium lepraemurium |
| mman | Mycobacterium mantenii |
| mser | Mycobacterium senriense |
| mul | Mycobacterium ulcerans |
| mmi | Mycobacterium marinum M |
| mmae | Mycobacterium marinum E11 |
| mli | Mycobacterium liflandii |
| mpse | Mycobacterium pseudoshottsii |
| msho | Mycobacterium shottsii |
| mmm | Mycobacterium sp. MOTT36Y |
| mkn | Mycobacterium kansasii ATCC 12478 |
| mshg | Mycobacterium shigaense |
| mfj | Mycobacterium florentinum |
| msto | Mycobacterium stomatepiae |
| msim | Mycobacterium simiae |
| mku | Mycobacterium kubicae |
| mlw | Mycobacterium lentiflavum |
| mpag | Mycobacterium paragordonae |
| mgor | Mycobacterium vicinigordonae |
| mbai | Mycobacterium basiliense |
| mseo | Mycobacterium seoulense |
| mbrd | Mycobacterium branderi |
| mshj | Mycobacterium shinjukuense |
| mspg | Mycobacterium spongiae |
| mot | Mycobacterium ostraviense |
| mhaf | Mycobacterium hainanense |
| mfx | Mycolicibacterium fallax |
| mij | Mycolicibacterium insubricum |
| maub | Mycolicibacterium aubagnense |
| mphu | Mycolicibacterium phocaicum |
| mmuc | Mycolicibacterium mucogenicum |
| mkr | Mycolicibacillus koreensis |
| mpak | Mycolicibacillus parakoreensis |
| mmin | Mycolicibacter minnesotensis |
| mhib | Mycolicibacter hiberniae |
| mher | Mycolicibacter heraklionensis |
| mvm | Mycolicibacter virginiensis |
| mkk | Mycobacterium kokjensenii |
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| Reaction |
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| Compound |
| C01209 | Malonyl-[acyl-carrier protein] |
| C22858 | Long-chain 3-oxoacyl-[acyl-carrier protein] |
| C20683 | Long-chain acyl-[acyl-carrier protein] |
| C22859 | Long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] |
| C22860 | Long-chain trans-2-enoyl-[acyl-carrier protein] |
| C22861 | Very-long-chain acyl-[acyl-carrier protein] |
| C22862 | Very-long-chain 3-oxoacyl-[acyl-carrier protein] |
| C22863 | Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] |
| C22864 | Very-long-chain trans-2-enoyl-[acyl-carrier protein] |
| C22865 | Ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] |
| C22866 | Ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] |
| C22867 | Ultra-long-chain mono-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] |
| C22868 | Ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein] |
| C22869 | Ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] |
| C22870 | Ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] |
| C22871 | Ultra-long-chain di-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] |
| C22872 | Ultra-long-chain di-unsaturated trans-2-enoyl-[acyl-carrier protein] |
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| RModule |
| RM021 | Fatty acid synthesis using malonyl-CoA |
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| Reference |
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| Authors |
Takayama K, Wang C, Besra GS. |
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| Title |
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. |
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| Journal |
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| Reference |
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| Authors |
Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H. |
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| Title |
Fatty acid biosynthesis in actinomycetes. |
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| Journal |
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| Reference |
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| Authors |
Marrakchi H, Laneelle MA, Daffe M. |
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| Title |
Mycolic acids: structures, biosynthesis, and beyond. |
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| Journal |
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| Reference |
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| Authors |
Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D. |
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| Title |
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes. |
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| Journal |
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| Reference |
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| Authors |
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A |
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| Title |
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. |
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| Journal |
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| LinkDB |
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