KEGG   MODULE: M00976
Entry
M00976            Pathway   Module                                 
Name
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Definition
K00512 K00070 (K04119,K10207,K13368,K13369,K13370) (K12343,K12344,K12345)
Diagram
M00976

Orthology
K00512  
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32] [RN:R03783 R08517]
K00070  
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] [RN:R01837]
K04119  
aldo-keto reductase family 1 member C3 [EC:1.1.1.51] [RN:R01836 R01838]
K10207  
testosterone 17beta-dehydrogenase (NADP+) [EC:1.1.1.64] [RN:R01838]
K13368,K13369,K13370  
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.239] [RN:R01836]
K12343,K12344,K12345  
3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22] [RN:R02497]
Class
Pathway modules; Lipid metabolism; Sterol biosynthesis
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
Reaction
R03783  
R08517  
R01837  
R01836,R01838  
R02497  
Compound
C01953  Pregnenolone
C05138  17alpha-Hydroxypregnenolone
C01227  Dehydroepiandrosterone
C00280  Androstenedione
C00535  Testosterone
C03917  Dihydrotestosterone
Reference
PMID:30943210
  Authors
Miller WL, Auchus RJ
  Title
The "backdoor pathway" of androgen synthesis in human male sexual development.
  Journal
PLoS Biol 17:e3000198 (2019)
DOI:10.1371/journal.pbio.3000198
LinkDB

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