KEGG   PATHWAY: acs00790
Entry
acs00790                    Pathway                                
Name
Folate biosynthesis - Anolis carolinensis (green anole)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
acs00790  Folate biosynthesis
acs00790

Module
acs_M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4 [PATH:acs00790]
Other DBs
GO: 0046656
Organism
Anolis carolinensis (green anole) [GN:acs]
Gene
100552531  mocos; molybdenum cofactor sulfurase [KO:K15631] [EC:2.8.1.9]
100552760  fpgs; folylpolyglutamate synthase [KO:K01930] [EC:6.3.2.17]
100554746  qdpr; quinoid dihydropteridine reductase [KO:K00357] [EC:1.5.1.34]
100555683  gphn; gephyrin [KO:K15376] [EC:2.10.1.1 2.7.7.75]
100559043  dhfr; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
100560114  gch1; GTP cyclohydrolase 1 [KO:K01495] [EC:3.5.4.16]
100561541  th; tyrosine hydroxylase [KO:K00501] [EC:1.14.16.2]
100562555  [KO:K00501] [EC:1.14.16.2]
100562752  pah; phenylalanine-4-hydroxylase [KO:K00500] [EC:1.14.16.1]
100562860  tph1; tryptophan hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
100562871  pcbd1; pterin-4 alpha-carbinolamine dehydratase 1 [KO:K01724] [EC:4.2.1.96]
100563090  pcbd2; pterin-4 alpha-carbinolamine dehydratase 2 [KO:K01724] [EC:4.2.1.96]
100563793  ggh; gamma-glutamyl hydrolase [KO:K01307] [EC:3.4.19.9]
100564587  [KO:K00011] [EC:1.1.1.21]
100564788  [KO:K00011] [EC:1.1.1.21]
100564918  tph2; tryptophan hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
100565095  mocs1; molybdenum cofactor synthesis 1 [KO:K20967] [EC:4.1.99.22 4.6.1.17]
100565932  spr; sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) [KO:K00072] [EC:1.1.1.153]
100566185  alpi; alkaline phosphatase, intestinal [KO:K01077] [EC:3.1.3.1]
100566385  [KO:K01077] [EC:3.1.3.1]
100566716  alpl; alkaline phosphatase, tissue-nonspecific isozyme [KO:K01077] [EC:3.1.3.1]
100567688  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100567950  [KO:K01737] [EC:4.2.3.12 4.1.2.50]
100568150  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
107983749  pts; 6-pyruvoyltetrahydropterin synthase [KO:K01737] [EC:4.2.3.12 4.1.2.50]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
acs00230  Purine metabolism
acs00400  Phenylalanine, tyrosine and tryptophan biosynthesis
acs00670  One carbon pool by folate
KO pathway
ko00790   

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