KEGG   PATHWAY: ajm04612
Entry
ajm04612                    Pathway                                
Name
Antigen processing and presentation - Artibeus jamaicensis (Jamaican fruit-eating bat)
Class
Organismal Systems; Immune system
Pathway map
ajm04612  Antigen processing and presentation
ajm04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119042309  IFNG; interferon gamma [KO:K04687]
119053704  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119037298  PSME1; proteasome activator complex subunit 1 isoform X1 [KO:K06696]
119037321  PSME2; proteasome activator complex subunit 2 isoform X1 [KO:K06697]
119051831  PSME3; proteasome activator complex subunit 3 [KO:K06698]
119044063  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
119039490  heat shock cognate 70 kDa protein 2 [KO:K03283]
119039566  heat shock 70 kDa protein 6 [KO:K03283]
119051561  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
119059918  heat shock 70 kDa protein 7, chloroplastic-like [KO:K03283]
119046069  heat shock cognate 70 kDa protein 2-like [KO:K03283]
119053663  heat shock 70 kDa protein cognate 4 isoform X1 [KO:K03283]
119053737  heat shock 70 kDa protein 1-like [KO:K03283]
119053750  heat shock 70 kDa protein 1 [KO:K03283]
119062443  heat shock 70 kDa protein 1A [KO:K03283]
119048100  heat shock-related 70 kDa protein 2-like [KO:K03283]
119058044  heat shock cognate 70 kDa protein 2-like [KO:K03283]
119034809  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
119037614  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
119037799  heat shock 70 kDa protein 15-like [KO:K09489]
119037939  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
119041136  LOW QUALITY PROTEIN: putative heat shock protein HSP 90-beta-3 [KO:K04079]
119046156  heat shock protein 90-5, chloroplastic-like [KO:K04079]
119061428  endoplasmin homolog [KO:K04079]
119047198  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
119047665  heat shock protein 81-1 [KO:K04079]
119035307  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
119035444  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
119035883  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119037417  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037803  HLA class I histocompatibility antigen, C alpha chain-like [KO:K06751]
119037804  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
119037805  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119037806  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037808  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
119037809  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119037811  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
119037812  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
119037813  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119037822  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119037824  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
119042380  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119058998  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119052950  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
119052964  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119052978  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
119053723  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119055211  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
119048072  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119063032  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119063033  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119055989  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119056406  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119056410  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119056413  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
119065069  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
119065880  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065881  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065882  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119065883  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119061149  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
119034519  calnexin homolog [KO:K08054]
119042608  CANX; calnexin [KO:K08054]
119055615  calnexin homolog [KO:K08054]
119054162  B2M; beta-2-microglobulin [KO:K08055]
119056491  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
119054160  calreticulin-like [KO:K08057]
119054624  calreticulin-3-like [KO:K08057]
119049665  CALR; calreticulin [KO:K08057]
119064588  calreticulin-3-like [KO:K08057]
119041195  tapasin isoform X1 [KO:K08058]
119049933  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
119049937  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
119034509  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
119034510  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
119048495  uncharacterized protein LOC119048495 [KO:K10785]
119048496  uncharacterized protein LOC119048496 [KO:K10785]
119040152  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119063470  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119063471  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
119065694  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119065696  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119065726  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119065738  LOW QUALITY PROTEIN: NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119065740  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119065731  natural killer cells antigen CD94-like isoform X1 [KO:K06516]
119065742  natural killer cells antigen CD94-like [KO:K06516]
119046831  IFI30; gamma-interferon-inducible lysosomal thiol reductase isoform X1 [KO:K08059]
119037886  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
119059121  vacuolar-processing enzyme-like [KO:K01369] [EC:3.4.22.34]
119039364  cathepsin B-like protease 2 [KO:K01363] [EC:3.4.22.1]
119049448  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
119038537  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
119040562  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119040793  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119040794  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119052984  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
119052987  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
119060698  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
119061214  H-2 class II histocompatibility antigen, A-D beta chain-like [KO:K06752]
119062087  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119055692  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119055693  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
119055694  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119048626  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
119056744  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119056745  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119049925  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119057940  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119061375  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
119040361  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
119052097  procathepsin L [KO:K01365] [EC:3.4.22.15]
119034681  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
119060419  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
119053559  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
119035081  RFX5; DNA-binding protein RFX5 [KO:K08061]
119054754  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
119054770  DNA-binding protein RFXANK isoform X1 [KO:K08062]
119044404  regulatory factor X-associated protein [KO:K08063]
119064343  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119056713  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
119060278  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
119045871  nuclear transcription factor Y subunit B-8-like [KO:K08065]
119045872  nuclear transcription factor Y subunit B-8-like [KO:K08065]
119052186  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
ajm03050  Proteasome
ajm04650  Natural killer cell mediated cytotoxicity
ajm04660  T cell receptor signaling pathway
KO pathway
ko04612   
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