KEGG   PATHWAY: alat04340
Entry
alat04340                   Pathway                                
Name
Hedgehog signaling pathway - Acanthopagrus latus (yellowfin seabream)
Description
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Class
Environmental Information Processing; Signal transduction
Pathway map
alat04340  Hedgehog signaling pathway
alat04340

Organism
Acanthopagrus latus (yellowfin seabream) [GN:alat]
Gene
119006548  megf8; multiple epidermal growth factor-like domains protein 8 [KO:K23664]
119007010  csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
119007457  cdon; cell adhesion molecule-related/down-regulated by oncogenes [KO:K20033]
119007694  kif3a; kinesin-like protein KIF3A isoform X1 [KO:K10394]
119007978  fbxw11a; F-box/WD repeat-containing protein 11a isoform X1 [KO:K03362]
119008225  shha; sonic hedgehog protein A [KO:K11988]
119008816  boc; brother of CDO [KO:K20020]
119008826  arrb1; beta-arrestin-1 [KO:K04439]
119008907  gli3; transcriptional activator GLI3 [KO:K06230]
119008962  hhatlb; hedgehog acyltransferase like, b isoform X1 [KO:K24679]
119009067  [KO:K03347]
119009458  csnk1db; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
119010200  [KO:K10523]
119010216  lrp2b; low-density lipoprotein receptor-related protein 2 [KO:K06233]
119010406  [KO:K23663]
119010427  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
119010908  hhatla; hedgehog acyltransferase like, a isoform X1 [KO:K24679]
119011053  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
119011121  [KO:K03869]
119011316  [KO:K11988]
119011464  [KO:K08958] [EC:2.7.11.1]
119011561  [KO:K04345] [EC:2.7.11.11]
119011808  ptch2; protein patched homolog 1 [KO:K11101]
119012732  disp1; protein dispatched homolog 1 [KO:K24680]
119013116  cul3b; cullin-3b isoform X1 [KO:K03869]
119013628  csnk1da; casein kinase I [KO:K08959] [EC:2.7.11.1]
119013794  ccndx; cyclin Dx [KO:K10151]
119013940  [KO:K08960] [EC:2.7.11.1]
119014049  [KO:K10523]
119014192  mosmoa; uncharacterized protein C16orf52 homolog B [KO:K23663]
119014273  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
119014286  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
119014347  mgrn1b; E3 ubiquitin-protein ligase MGRN1b isoform X1 [KO:K10604] [EC:2.3.2.27]
119014564  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
119015197  [KO:K16798]
119015258  [KO:K11989]
119017121  iqce; IQ domain-containing protein E [KO:K24677]
119017539  [KO:K06232]
119017665  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119018084  scube2; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1 [KO:K24706]
119018470  kif7; kinesin-like protein kif7 [KO:K18806]
119018496  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119018569  csnk1g1; casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
119018996  gas1a; growth arrest-specific protein 1a [KO:K06232]
119019829  ptch1; protein patched homolog 1 isoform X1 [KO:K06225]
119021168  [KO:K19608]
119021169  [KO:K19605]
119021742  gli1; zinc finger protein GLI1 isoform X1 [KO:K16797]
119022885  dhh; desert hedgehog protein [KO:K11990]
119023193  [KO:K04678] [EC:2.3.2.26]
119023886  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
119025008  [KO:K04503]
119025321  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119025702  lrp2a; low-density lipoprotein receptor-related protein 2a isoform X1 [KO:K06233]
119025834  [KO:K06231]
119026051  spopla; speckle-type POZ protein-like A [KO:K10523]
119026284  gpr161a; G-protein coupled receptor 161 [KO:K08439]
119026334  [KO:K11989]
119026351  gli2a; zinc finger protein GLI2a isoform X1 [KO:K16798]
119027325  arrb2b; arrestin, beta 2b isoform X1 [KO:K04439]
119028369  efcab7; EF-hand calcium-binding domain-containing protein 7 [KO:K23852]
119028389  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
119028460  csnk1g2b; casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
119029510  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
119030610  gas1b; growth arrest-specific protein 1b [KO:K06232]
119030992  [KO:K04439]
119032712  [KO:K10151]
119032750  smo; smoothened homolog [KO:K06226]
119033648  hhat; protein-cysteine N-palmitoyltransferase HHAT isoform X1 [KO:K24678]
119033888  sufu; suppressor of fused homolog isoform X1 [KO:K06229]
Compound
C00575  3',5'-Cyclic AMP
Reference
PMID:26875496
  Authors
Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
  Title
Hedgehog receptor function during craniofacial development.
  Journal
Dev Biol 415:198-215 (2016)
DOI:10.1016/j.ydbio.2016.02.009
Reference
PMID:23719536
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
PMID:26077918
  Authors
Alman BA
  Title
The role of hedgehog signalling in skeletal health and disease.
  Journal
Nat Rev Rheumatol 11:552-60 (2015)
DOI:10.1038/nrrheum.2015.84
Reference
PMID:26064136
  Authors
Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
  Title
Hedgehog and Resident Vascular Stem Cell Fate.
  Journal
Stem Cells Int 2015:468428 (2015)
DOI:10.1155/2015/468428
Reference
PMID:23799571
  Authors
Sasai N, Briscoe J
  Title
Primary cilia and graded Sonic Hedgehog signaling.
  Journal
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
DOI:10.1002/wdev.43
Reference
PMID:20708941
  Authors
Heretsch P, Tzagkaroulaki L, Giannis A
  Title
Modulators of the hedgehog signaling pathway.
  Journal
Bioorg Med Chem 18:6613-24 (2010)
DOI:10.1016/j.bmc.2010.07.038
Reference
PMID:22534646
  Authors
Anderson E, Peluso S, Lettice LA, Hill RE
  Title
Human limb abnormalities caused by disruption of hedgehog signaling.
  Journal
Trends Genet 28:364-73 (2012)
DOI:10.1016/j.tig.2012.03.012
Reference
PMID:18583599
  Authors
Rohatgi R, Scott MP
  Title
Cell biology. Arrestin' movement in cilia.
  Journal
Science 320:1726-7 (2008)
DOI:10.1126/science.1160448
Reference
PMID:24925320
  Authors
Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
  Title
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
  Journal
Elife 3:e02555 (2014)
DOI:10.7554/eLife.02555
Reference
PMID:22056910
  Authors
Ok CY, Singh RR, Vega F
  Title
Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
  Journal
Am J Pathol 180:2-11 (2012)
DOI:10.1016/j.ajpath.2011.09.009
Reference
PMID:26366162
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
PMID:29290584
  Authors
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
  Title
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
  Journal
Dev Cell 44:113-129.e8 (2018)
DOI:10.1016/j.devcel.2017.12.003
Reference
PMID:24582806
  Authors
Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R
  Title
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.
  Journal
Dev Cell 28:483-96 (2014)
DOI:10.1016/j.devcel.2014.01.021
Reference
PMID:27779865
  Authors
Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW
  Title
Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.
  Journal
ACS Chem Biol 11:3256-3262 (2016)
DOI:10.1021/acschembio.6b00896
Related
pathway
alat04120  Ubiquitin mediated proteolysis
KO pathway
ko04340   

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