KEGG   PATHWAY: anan00010
Entry
anan00010                   Pathway                                
Name
Glycolysis / Gluconeogenesis - Aotus nancymaae (Ma's night monkey)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
anan00010  Glycolysis / Gluconeogenesis
anan00010

Module
anan_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:anan00010]
anan_M00002  Glycolysis, core module involving three-carbon compounds [PATH:anan00010]
anan_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:anan00010]
anan_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:anan00010]
Other DBs
GO: 0006096 0006094
Organism
Aotus nancymaae (Ma's night monkey) [GN:anan]
Gene
105704715  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
105705007  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
105706999  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
105707132  HK3; hexokinase-3 [KO:K00844] [EC:2.7.1.1]
105707180  GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, testis-specific [KO:K10705] [EC:1.2.1.12]
105707516  GPI; glucose-6-phosphate isomerase isoform X1 [KO:K01810] [EC:5.3.1.9]
105708070  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
105708075  GCK; hexokinase-4 isoform X1 [KO:K12407] [EC:2.7.1.2]
105708153  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
105708857  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
105709042  [KO:K00016] [EC:1.1.1.27]
105709249  [KO:K01834] [EC:5.4.2.11]
105709464  [KO:K00850] [EC:2.7.1.11]
105709575  PGK2; phosphoglycerate kinase 2 [KO:K00927] [EC:2.7.2.3]
105709935  [KO:K03841] [EC:3.1.3.11]
105710113  [KO:K00134] [EC:1.2.1.12]
105710268  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
105710670  LDHAL6B; L-lactate dehydrogenase A-like 6B [KO:K00016] [EC:1.1.1.27]
105711285  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
105711386  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
105711768  PFKL; ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
105712290  [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
105712678  [KO:K00134] [EC:1.2.1.12]
105713532  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
105713845  [KO:K00016] [EC:1.1.1.27]
105714145  ENO4; enolase 4 isoform X1 [KO:K27394]
105715124  ALDOC; fructose-bisphosphate aldolase C [KO:K01623] [EC:4.1.2.13]
105715486  PKLR; pyruvate kinase PKLR isoform X1 [KO:K12406] [EC:2.7.1.40]
105715808  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
105716559  ADPGK; ADP-dependent glucokinase isoform X1 [KO:K08074] [EC:2.7.1.147]
105716569  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
105716673  HK1; hexokinase-1 isoform X2 [KO:K00844] [EC:2.7.1.1]
105716693  HKDC1; hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
105717137  HK2; hexokinase-2 isoform X1 [KO:K00844] [EC:2.7.1.1]
105717539  [KO:K13951] [EC:1.1.1.1]
105717540  [KO:K13951] [EC:1.1.1.1]
105717541  [KO:K13951] [EC:1.1.1.1]
105717661  ALDH3B2; aldehyde dehydrogenase family 3 member B2 [KO:K00129] [EC:1.2.1.5]
105717664  ALDH3B1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]
105718833  [KO:K00927] [EC:2.7.2.3]
105719199  ACSS2; acetyl-coenzyme A synthetase, cytoplasmic isoform X1 [KO:K01895] [EC:6.2.1.1]
105719565  [KO:K00134] [EC:1.2.1.12]
105719608  PGK1; phosphoglycerate kinase 1 [KO:K00927] [EC:2.7.2.3]
105719698  [KO:K00873] [EC:2.7.1.40]
105719716  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
105719994  LDHAL6A; L-lactate dehydrogenase A-like 6A [KO:K00016] [EC:1.1.1.27]
105719995  [KO:K00016] [EC:1.1.1.27]
105720198  [KO:K00016] [EC:1.1.1.27]
105720327  [KO:K01803] [EC:5.3.1.1]
105720527  LDHB; L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
105721817  [KO:K00134] [EC:1.2.1.12]
105721881  PFKM; ATP-dependent 6-phosphofructokinase, muscle type [KO:K00850] [EC:2.7.1.11]
105722312  [KO:K00016] [EC:1.1.1.27]
105722831  ENO3; beta-enolase isoform X2 [KO:K01689] [EC:4.2.1.11]
105723070  [KO:K00016] [EC:1.1.1.27]
105723394  [KO:K00134] [EC:1.2.1.12]
105723770  FBP1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
105723771  FBP2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
105724314  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
105725495  ALDOA; fructose-bisphosphate aldolase A [KO:K01623] [EC:4.1.2.13]
105725496  [KO:K00134] [EC:1.2.1.12]
105726335  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
105727206  PFKP; ATP-dependent 6-phosphofructokinase, platelet type isoform X2 [KO:K00850] [EC:2.7.1.11]
105727327  ALDOB; fructose-bisphosphate aldolase B [KO:K01623] [EC:4.1.2.13]
105727524  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
105727552  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105727588  MINPP1; multiple inositol polyphosphate phosphatase 1 isoform X1 [KO:K03103] [EC:3.1.3.62 3.1.3.80]
105728311  ACSS1; acetyl-coenzyme A synthetase 2-like, mitochondrial isoform X1 [KO:K01895] [EC:6.2.1.1]
105728501  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
105728603  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
105729388  [KO:K00016] [EC:1.1.1.27]
105729615  DLAT; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
105730475  [KO:K01834] [EC:5.4.2.11]
105730700  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
105730705  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
105731129  [KO:K00134] [EC:1.2.1.12]
105731166  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
105731176  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105731180  TPI1; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
105731743  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
105732622  [KO:K13952] [EC:1.1.1.1]
105732627  [KO:K13980] [EC:1.1.1.1]
105732750  PGM2; phosphopentomutase isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
105733103  GALM; galactose mutarotase [KO:K01785] [EC:5.1.3.3]
105734037  [KO:K00134] [EC:1.2.1.12]
110566991  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
110567003  [KO:K13951] [EC:1.1.1.1]
110567339  [KO:K01834] [EC:5.4.2.11]
110568161  [KO:K00134] [EC:1.2.1.12]
110568445  [KO:K00627] [EC:2.3.1.12]
110568802  [KO:K00927] [EC:2.7.2.3]
110568838  [KO:K00016] [EC:1.1.1.27]
110569373  PGAM4; LOW QUALITY PROTEIN: phosphoglycerate mutase 4 [KO:K01834] [EC:5.4.2.11]
110569391  [KO:K00134] [EC:1.2.1.12]
135268296  [KO:K01834] [EC:5.4.2.11]
135268673  [KO:K00134] [EC:1.2.1.12]
135269399  [KO:K01834] [EC:5.4.2.11]
135270657  [KO:K00873] [EC:2.7.1.40]
135271906  [KO:K00134] [EC:1.2.1.12]
135272002  [KO:K03841] [EC:3.1.3.11]
135272723  [KO:K00134] [EC:1.2.1.12]
135273122  [KO:K03841] [EC:3.1.3.11]
135273595  [KO:K03841] [EC:3.1.3.11]
135273657  [KO:K00134] [EC:1.2.1.12]
135274167  [KO:K00016] [EC:1.1.1.27]
135274854  [KO:K01834] [EC:5.4.2.11]
135275220  [KO:K00873] [EC:2.7.1.40]
135275694  [KO:K00134] [EC:1.2.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
anan00020  Citrate cycle (TCA cycle)
anan00030  Pentose phosphate pathway
anan00500  Starch and sucrose metabolism
anan00620  Pyruvate metabolism
anan00640  Propanoate metabolism
KO pathway
ko00010   

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