KEGG   PATHWAY: apla04530
Entry
apla04530                   Pathway                                
Name
Tight junction - Anas platyrhynchos (mallard)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
apla04530  Tight junction
apla04530

Other DBs
GO: 0005923
Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
101795449  CLDN34; claudin-34 [KO:K06087]
101800092  CLDN2; claudin-2 [KO:K06087]
101791882  claudin-22 [KO:K06087]
101802851  claudin-4 [KO:K06087]
101790278  claudin-3 [KO:K06087]
101790465  claudin-3 [KO:K06087]
101802171  CLDN8; claudin-8 [KO:K06087]
101803693  claudin-8 [KO:K06087]
101792045  CLDN20; claudin-20 [KO:K06087]
101801749  CLDN25; putative claudin-25 [KO:K06087]
101794867  CLDN18; claudin-18 isoform X2 [KO:K06087]
101795361  CLDN16; claudin-16 isoform X1 [KO:K06087]
101797741  CLDN1; claudin-1 [KO:K06087]
101793875  CLDN14; claudin-14 [KO:K06087]
101793937  claudin-16 isoform X1 [KO:K06087]
101793759  CLDN19; claudin-19 [KO:K06087]
101799421  claudin-15 isoform X2 [KO:K06087]
101792303  CLDN10; claudin-10 isoform X3 [KO:K06087]
110352719  CLDN23; claudin-23 [KO:K06087]
113844461  CLDN11; claudin-11 [KO:K06087]
113840444  CLDN5; LOW QUALITY PROTEIN: claudin-5 [KO:K06087]
101795774  CLDN12; claudin-12 [KO:K06087]
119714189  LOW QUALITY PROTEIN: occludin-like [KO:K06088]
101789889  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
101791636  JAM3; junctional adhesion molecule C [KO:K06785]
101792652  BVES; blood vessel epicardial substance isoform X5 [KO:K21108]
101791907  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101794203  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
101794093  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101791510  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101803601  MPP5; MAGUK p55 subfamily member 5 [KO:K06091]
101795206  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
101805271  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
101796048  PATJ; inaD-like protein isoform X1 [KO:K06092]
101797155  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
101801184  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
101801136  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101795203  AMOT; LOW QUALITY PROTEIN: angiomotin [KO:K16819]
101803417  AMOTL1; LOW QUALITY PROTEIN: angiomotin-like protein 1 [KO:K06104]
101799514  AMOTL2; LOW QUALITY PROTEIN: angiomotin-like protein 2 [KO:K06104]
101804588  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
101801980  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101791895  merlin isoform X1 [KO:K16684]
101796182  NF2; merlin isoform X1 [KO:K16684]
101798171  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
101792114  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
101792004  SCRIB; protein scribble homolog isoform X2 [KO:K16175]
101799879  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101803206  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101798527  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2 [KO:K04354]
101801149  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101797307  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
119713486  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101792870  PARD3; LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
101803496  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101791291  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
101794539  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
101793279  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
101798491  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
101800777  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
101802565  CGN; LOW QUALITY PROTEIN: cingulin [KO:K06102]
101801112  CGNL1; cingulin-like protein 1 isoform X4 [KO:K21110]
101797910  RHOA; transforming protein RhoA [KO:K04513]
101796398  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
106017580  MARVEL domain-containing protein 3-like [KO:K21099]
101793796  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
101793656  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
101799011  MAPK9; mitogen-activated protein kinase 9 isoform X5 [KO:K04440] [EC:2.7.11.24]
101793594  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106014314  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101796626  JUN; transcription factor AP-1 [KO:K04448]
101798100  antigen-presenting glycoprotein CD1d isoform X2 [KO:K06448]
101798404  T-cell surface glycoprotein CD1b-3 isoform X1 [KO:K06448]
101796317  antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
101794457  antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
101800410  T-cell surface glycoprotein CD1b-3 [KO:K06448]
113845764  antigen-presenting glycoprotein CD1d-like [KO:K06448]
101803386  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
101794589  YBX3; Y-box-binding protein 3 [KO:K06099]
119713445  PCNA; proliferating cell nuclear antigen [KO:K04802]
101800639  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
101799657  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
101803843  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
106014700  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101796544  LOW QUALITY PROTEIN: ezrin [KO:K08007]
101794726  RDX; radixin isoform X1 [KO:K05762]
119717942  MSN; LOW QUALITY PROTEIN: moesin [KO:K05763]
101795629  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
101800437  ACTB; actin, cytoplasmic 1 [KO:K05692]
119713181  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
101792739  actin, cytoplasmic type 5 [KO:K05692]
101803307  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101799109  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101797249  SRC; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101802254  CTTN; src substrate cortactin isoform X1 [KO:K06106]
101793940  hematopoietic lineage cell-specific protein [KO:K06106]
101795715  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101796775  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101795656  ACTR3; actin-related protein 3 [KO:K18584]
101801780  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101804698  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101792760  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101792866  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
110353581  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101794157  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
101791856  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
119713815  RAB13; ras-related protein Rab-13 [KO:K06109]
101794832  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X2 [KO:K21066]
101797330  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
101792620  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
119718633  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
101801218  EPB41L4B; band 4.1-like protein 4B [KO:K21111]
101795686  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101801595  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101799561  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101805480  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101803934  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X3 [KO:K07199]
101803710  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
113844108  PRKAG3; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
119715285  PRKAG1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
101789798  MYH10; myosin-10 isoform X2 [KO:K10352]
101802795  MYH9; myosin-9 [KO:K10352]
101803563  MYH11; myosin-11 isoform X1 [KO:K10352]
119714636  MYL6; LOW QUALITY PROTEIN: myosin light polypeptide 6 [KO:K12751]
101799368  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101795371  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
113842832  myosin regulatory light polypeptide 9 [KO:K12757]
101791567  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
101798789  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
119718350  SYNPO; synaptopodin isoform X1 [KO:K21112]
101795217  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
119714260  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101794204  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
101791620  RAB8A; ras-related protein Rab-8A [KO:K07901]
101795928  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
101804493  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
101800296  RAP1A; ras-related protein Rap-1A [KO:K04353]
101792849  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101799402  AFDN; afadin isoform X12 [KO:K05702]
101798664  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
101802476  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
101805465  RAP2C; ras-related protein Rap-2c [KO:K07839]
101791936  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
101804607  tubulin alpha-4 chain [KO:K07374]
101804924  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
101795602  tubulin alpha-3 chain isoform X1 [KO:K07374]
101804425  tubulin alpha-2 chain [KO:K07374]
101797289  tubulin alpha-8 chain isoform X1 [KO:K07374]
101805041  tubulin alpha-4A chain [KO:K07374]
101802038  tubulin alpha-5 chain [KO:K07374]
119714717  tubulin alpha-1A chain [KO:K07374]
119714718  tubulin alpha-1C chain-like [KO:K07374]
119715301  tubulin alpha-1B chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
apla04520  Adherens junction
apla04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

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