KEGG   PATHWAY: ath04145
Entry
ath04145                    Pathway                                
Name
Phagosome - Arabidopsis thaliana (thale cress)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
ath04145  Phagosome
ath04145

Other DBs
GO: 0045335
Organism
Arabidopsis thaliana (thale cress) [GN:ath]
Gene
AT1G04820  TUA4; tubulin alpha-4 chain [KO:K07374]
AT1G08450  CRT3; calreticulin 3 [KO:K08057]
AT1G09210  CRT1b; calreticulin 1b [KO:K08057]
AT1G11890  SEC22; Synaptobrevin family protein [KO:K08517]
AT1G12840  DET3; vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3) [KO:K02148]
AT1G19910  AVA-P2; ATPase, F0/V0 complex, subunit C protein [KO:K02155]
AT1G20010  TUB5; tubulin beta-5 chain [KO:K07375]
AT1G20090  ROP2; RHO-related protein from plants 2 [KO:K04392]
AT1G20260  VAB3; ATPase, V1 complex, subunit B protein [KO:K02147]
AT1G22740  RABG3B; RAB GTPase homolog G3B [KO:K07897]
AT1G29310  [KO:K10956]
AT1G34260  FAB1D; FORMS APLOID AND BINUCLEATE CELLS 1A [KO:K00921] [EC:2.7.1.150]
AT1G50010  TUA2; tubulin alpha-2 chain [KO:K07374]
AT1G51740  SYP81; syntaxin of plants 81 [KO:K08492]
AT1G52280  RABG3d; RAB GTPase homolog G3D [KO:K07897]
AT1G56340  CRT1a; calreticulin 1a [KO:K08057]
AT1G60490  VPS34; vacuolar protein sorting 34 [KO:K00914] [EC:2.7.1.137]
AT1G64200  VHA-E3; vacuolar H+-ATPase subunit E isoform 3 [KO:K02150]
AT1G64740  TUA1; alpha-1 tubulin [KO:K07374]
AT1G71010  FAB1C; FORMS APLOID AND BINUCLEATE CELLS 1C [KO:K00921] [EC:2.7.1.150]
AT1G75630  AVA-P4; vacuolar H+-pumping ATPase 16 kDa proteolipid subunit 4 [KO:K02155]
AT1G75780  TUB1; tubulin beta-1 chain [KO:K07375]
AT1G75840  ARAC5; RAC-like GTP binding protein 5 [KO:K04392]
AT1G76030  VAB1; ATPase, V1 complex, subunit B protein [KO:K02147]
AT1G78720  [KO:K10956]
AT1G78900  VHA-A; vacuolar ATP synthase subunit A [KO:K02145] [EC:7.1.2.2]
AT2G16510  [KO:K02155]
AT2G17800  ARAC1; RAC-like 1 [KO:K04392]
AT2G18710  SCY1; SECY homolog 1 [KO:K10956]
AT2G21410  VHA-A2; vacuolar proton ATPase A2 [KO:K02154]
AT2G21880  RAB7A; RAB GTPase homolog 7A [KO:K07897]
AT2G25610  [KO:K03661]
AT2G28520  VHA-A1; vacuolar proton ATPase A1 [KO:K02154]
AT2G29550  TUB7; tubulin beta-7 chain [KO:K07375]
AT2G34250  [KO:K10956]
AT2G44690  ARAC9; RAC-like 9 [KO:K04392]
AT2G45070  SEC61_BETA; Preprotein translocase Sec, Sec61-beta subunit protein [KO:K09481]
AT3G01390  VMA10; vacuolar membrane ATPase 10 [KO:K02152]
AT3G08560  VHA-E2; vacuolar H+-ATPase subunit E isoform 2 [KO:K02150]
AT3G14270  FAB1B; phosphatidylinositol-4-phosphate 5-kinase family protein [KO:K00921] [EC:2.7.1.150]
AT3G16100  RABG3c; RAB GTPase homolog G3C [KO:K07897]
AT3G18820  RAB7B; RAB GTPase homolog G3F [KO:K07897]
AT3G28710  [KO:K02146]
AT3G28715  [KO:K02146]
AT3G42050  [KO:K02144]
AT3G48040  ROP10; RHO-related protein from plants 10 [KO:K04392]
AT3G48570  [KO:K07342]
AT3G51300  ROP1; RHO-related protein from plants 1 [KO:K04392]
AT3G54840  ARA6; Ras-related small GTP-binding family protein [KO:K07887]
AT3G58730  [KO:K02149]
AT3G60540  [KO:K09481]
AT4G02620  [KO:K02151]
AT4G09720  RABG3A; RAB GTPase homolog G3A [KO:K07897]
AT4G11150  TUF; vacuolar ATP synthase subunit E1 [KO:K02150]
AT4G14960  TUA6; Tubulin/FtsZ family protein [KO:K07374]
AT4G19640  ARA7; Ras-related small GTP-binding family protein [KO:K07887]
AT4G20890  TUB9; tubulin beta-9 chain [KO:K07375]
AT4G23710  VAG2; vacuolar ATP synthase subunit G2 [KO:K02152]
AT4G24920  [KO:K07342]
AT4G25950  VATG3; vacuolar ATP synthase G3 [KO:K02152]
AT4G26710  [KO:K02153]
AT4G28950  ROP9; RHO-related protein from plants 9 [KO:K04392]
AT4G32530  [KO:K03661]
AT4G33240  FAB1A; 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A [KO:K00921] [EC:2.7.1.150]
AT4G34720  AVA-P1; ATPase, F0/V0 complex, subunit C protein [KO:K02155]
AT4G35020  RAC3; RAC-like 3 [KO:K04392]
AT4G35950  RAC6; RAC-like 6 [KO:K04392]
AT4G38510  VAB2; ATPase, V1 complex, subunit B protein [KO:K02147]
AT4G38920  VHA-C3; vacuolar-type H[+]-ATPase C3 [KO:K02155]
AT4G39080  VHA-A3; vacuolar proton ATPase A3 [KO:K02154]
AT5G07340  [KO:K08054]
AT5G12250  TUB6; beta-6 tubulin [KO:K07375]
AT5G19770  TUA3; tubulin alpha-3 [KO:K07374]
AT5G19780  TUA5; tubulin alpha-5 [KO:K07374]
AT5G23860  TUB8; tubulin beta 8 [KO:K07375]
AT5G44340  TUB4; tubulin beta chain 4 [KO:K07375]
AT5G45130  RHA1; Ras small GTP-binding family protein [KO:K07887]
AT5G45970  RAC2; RAC-like 2 [KO:K04392]
AT5G50460  [KO:K07342]
AT5G52270  [KO:K08517]
AT5G55290  [KO:K02153]
AT5G60460  [KO:K09481]
AT5G61790  CNX1; calnexin 1 [KO:K08054]
AT5G62690  TUB2; tubulin beta chain 2 [KO:K07375]
AT5G62700  TUB3; tubulin beta chain 3 [KO:K07375]
AT5G62880  RAC10; RAC-like 10 [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
ath04142  Lysosome
ath04144  Endocytosis
ath04620  Toll-like receptor signaling pathway
KO pathway
ko04145   

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