KEGG   PATHWAY: bacu03040
Entry
bacu03040                   Pathway                                
Name
Spliceosome - Balaenoptera acutorostrata scammoni (minke whale)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
bacu03040  Spliceosome
bacu03040

Other DBs
GO: 0005681
Organism
Balaenoptera acutorostrata scammoni (minke whale) [GN:bacu]
Gene
102997676  [KO:K11086]
102998256  PRPF8; pre-mRNA processing factor 8 [KO:K12856]
102998554  BUD31; BUD31 homolog [KO:K12873]
102998743  CCDC12; coiled-coil domain containing 12 [KO:K12871]
102999023  RBM17; RNA binding motif protein 17 [KO:K12840]
102999543  PRPF40B; pre-mRNA processing factor 40 homolog B [KO:K12821]
102999622  PLRG1; pleiotropic regulator 1 [KO:K12862]
102999791  [KO:K12900]
102999964  DDX46; DEAD-box helicase 46 [KO:K12811] [EC:3.6.4.13]
103000802  CTNNBL1; catenin beta like 1 [KO:K12864]
103001063  SF3A1; splicing factor 3a subunit 1 [KO:K12825]
103001114  AQR; aquarius intron-binding spliceosomal factor [KO:K12874]
103001298  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
103001416  RBM25; RNA binding motif protein 25 [KO:K12822]
103001515  PHF5A; PHD finger protein 5A [KO:K12834]
103001552  U2AF2; U2 small nuclear RNA auxiliary factor 2 [KO:K12837]
103001600  SRSF7; serine and arginine rich splicing factor 7 [KO:K12896]
103002062  SART1; squamous cell carcinoma antigen recognized by T-cells 1 [KO:K11984]
103002280  TCERG1; transcription elongation regulator 1 [KO:K12824]
103002889  CRNKL1; crooked neck pre-mRNA splicing factor 1 [KO:K12869]
103003027  CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
103003108  PRPF3; pre-mRNA processing factor 3 [KO:K12843]
103003111  PRPF4; pre-mRNA processing factor 4 [KO:K12662]
103003256  SLU7; SLU7 homolog, splicing factor [KO:K12819]
103003347  DHX15; DEAH-box helicase 15 [KO:K12820] [EC:3.6.4.13]
103003350  SNU13; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) [KO:K12845]
103003382  SNRPG; small nuclear ribonucleoprotein polypeptide G [KO:K11099]
103003387  [KO:K12879]
103003689  [KO:K19604]
103003751  USP39; ubiquitin specific peptidase 39 [KO:K12847]
103003836  SMNDC1; survival motor neuron domain containing 1 [KO:K12839]
103003978  FUS; FUS RNA binding protein [KO:K13098]
103003979  PUF60; poly(U) binding splicing factor 60 [KO:K12838]
103004221  PPIL1; peptidylprolyl isomerase like 1 [KO:K12733] [EC:5.2.1.8]
103004724  [KO:K12845]
103004761  THOC1; THO complex 1 [KO:K12878]
103004863  ZMAT2; zinc finger matrin-type 2 [KO:K12848]
103004899  SF3B6; splicing factor 3b subunit 6 [KO:K12833]
103005038  CDC40; cell division cycle 40 [KO:K12816]
103005214  LSM6; LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12625]
103005644  SF3A3; splicing factor 3a subunit 3 [KO:K12827]
103005674  BCAS2; BCAS2, pre-mRNA processing factor [KO:K12861]
103005706  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
103005708  PCBP1; poly(rC) binding protein 1 [KO:K12889]
103005820  [KO:K12892]
103006061  NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
103006115  RBM8A; RNA binding motif protein 8A [KO:K12876]
103006154  HNRNPM; heterogeneous nuclear ribonucleoprotein M [KO:K12887]
103006414  SRSF2; serine and arginine rich splicing factor 2 [KO:K12891]
103006475  MAGOHB; mago homolog B, exon junction complex core component [KO:K12877]
103006501  MAGOH; mago homolog, exon junction complex core component [KO:K12877]
103006546  SF3B2; splicing factor 3b subunit 2 [KO:K12829]
103006864  SRSF1; serine and arginine rich splicing factor 1 [KO:K12890]
103007052  SNRNP27; small nuclear ribonucleoprotein U4/U6.U5 subunit 27 [KO:K12846]
103007364  SNRPD3; small nuclear ribonucleoprotein D3 polypeptide [KO:K11088]
103007450  DDX39B; DExD-box helicase 39B [KO:K12812] [EC:3.6.4.13]
103007593  SNRPE; small nuclear ribonucleoprotein polypeptide E [KO:K11097]
103007677  PQBP1; polyglutamine binding protein 1 [KO:K12865]
103007762  DHX38; DEAH-box helicase 38 [KO:K12815] [EC:3.6.4.13]
103008022  SRSF4; serine and arginine rich splicing factor 4 [KO:K12893]
103008061  ISY1; ISY1 splicing factor homolog [KO:K12870]
103008173  ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
103008337  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
103008422  LSM4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12623]
103008490  TRA2A; transformer 2 alpha homolog [KO:K12897]
103008779  SNRNP70; small nuclear ribonucleoprotein U1 subunit 70 [KO:K11093]
103009144  PPIE; peptidylprolyl isomerase E [KO:K09564] [EC:5.2.1.8]
103009581  SRSF6; serine and arginine rich splicing factor 6 [KO:K12893]
103010200  [KO:K12741]
103010673  SNRPD1; small nuclear ribonucleoprotein D1 polypeptide [KO:K11087]
103010678  SYF2; SYF2 pre-mRNA splicing factor [KO:K12868]
103010763  SF3A2; splicing factor 3a subunit 2 [KO:K12826]
103011092  SNRPF; small nuclear ribonucleoprotein polypeptide F [KO:K11098]
103011171  SRSF9; serine and arginine rich splicing factor 9 [KO:K21123]
103011296  THOC3; THO complex 3 [KO:K12880]
103011655  SNW1; SNW domain containing 1 [KO:K06063]
103011755  PRPF6; pre-mRNA processing factor 6 [KO:K12855]
103012043  RBMX; RNA binding motif protein, X-linked [KO:K12885]
103012197  RP9; retinitis pigmentosa 9 (autosomal dominant) [KO:K19604]
103012224  DHX8; DEAH-box helicase 8 [KO:K12818] [EC:3.6.4.13]
103012489  LSM7; LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12626]
103012527  PRPF38A; pre-mRNA processing factor 38A [KO:K12849]
103012633  [KO:K11092]
103012709  SNRPA; small nuclear ribonucleoprotein polypeptide A [KO:K11091]
103012858  CDC5L; cell division cycle 5 like [KO:K12860]
103013165  [KO:K12892]
103013268  [KO:K12741]
103013532  DDX5; DEAD-box helicase 5 [KO:K12823] [EC:3.6.4.13]
103013772  SNRNP40; small nuclear ribonucleoprotein U5 subunit 40 [KO:K12857]
103013829  LSM3; LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12622]
103013978  [KO:K19604]
103014693  RBM22; RNA binding motif protein 22 [KO:K12872]
103015098  LSM5; LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12624]
103015163  SF3B1; splicing factor 3b subunit 1 [KO:K12828]
103015170  SNRPB2; small nuclear ribonucleoprotein polypeptide B2 [KO:K11094]
103015325  CWC15; CWC15 spliceosome associated protein homolog [KO:K12863]
103015421  SNRPD2; small nuclear ribonucleoprotein D2 polypeptide [KO:K11096]
103015481  DDX23; DEAD-box helicase 23 [KO:K12858] [EC:3.6.4.13]
103015565  [KO:K13098]
103015877  PPIH; peptidylprolyl isomerase H [KO:K09567] [EC:5.2.1.8]
103015975  SRSF5; serine and arginine rich splicing factor 5 [KO:K12893]
103015992  HNRNPU; heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) [KO:K12888]
103016253  PRPF31; pre-mRNA processing factor 31 [KO:K12844]
103016345  PRPF40A; pre-mRNA processing factor 40 homolog A [KO:K12821]
103016467  XAB2; XPA binding protein 2 [KO:K12867]
103016668  DHX16; DEAH-box helicase 16 [KO:K12813] [EC:3.6.4.13]
103016815  U2AF1L4; U2 small nuclear RNA auxiliary factor 1 like 4 [KO:K12836]
103017314  PRPF38B; pre-mRNA processing factor 38B [KO:K12850]
103017347  PRPF19; pre-mRNA processing factor 19 [KO:K10599] [EC:2.3.2.27]
103017634  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
103017700  SF3B5; splicing factor 3b subunit 5 [KO:K12832]
103017914  TRA2B; transformer 2 beta homolog (Drosophila) [KO:K12897]
103018080  U2AF1; U2 small nuclear RNA auxiliary factor 1 [KO:K12836]
103018146  ALYREF; Aly/REF export factor [KO:K12881]
103018583  SF3B3; splicing factor 3b subunit 3 [KO:K12830]
103018603  [KO:K12893]
103018753  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
103018787  U2SURP; U2 snRNP associated SURP domain containing [KO:K12842]
103019111  DDX42; DEAD-box helicase 42 [KO:K12835] [EC:3.6.4.13]
103019308  [KO:K12884]
103019337  [KO:K12741]
103019485  SNRPC; small nuclear ribonucleoprotein polypeptide C [KO:K11095]
103019651  SNRNP200; small nuclear ribonucleoprotein U5 subunit 200 [KO:K12854] [EC:3.6.4.13]
103019729  [KO:K03283]
103019761  EFTUD2; elongation factor Tu GTP binding domain containing 2 [KO:K12852]
103019924  SRSF10; serine and arginine rich splicing factor 10 [KO:K12900]
103020014  [KO:K03283]
103020080  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
103020298  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
103020369  TXNL4A; thioredoxin like 4A [KO:K12859]
103020432  EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:3.6.4.13]
103020687  SF3B4; splicing factor 3b subunit 4 [KO:K12831]
103020764  LSM2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12621]
103020958  WBP11; WW domain binding protein 11 [KO:K12866]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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