KEGG   PATHWAY: bit00260
Entry
bit00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus spizizenii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bit00260  Glycine, serine and threonine metabolism
bit00260

Module
bit_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bit00260]
bit_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bit00260]
bit_M00555  Betaine biosynthesis, choline => betaine [PATH:bit00260]
bit_M00621  Glycine cleavage system [PATH:bit00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus spizizenii [GN:bit]
Gene
BIS30_19240  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BIS30_12475  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BIS30_03655  aspartate kinase [KO:K00928] [EC:2.7.2.4]
BIS30_19235  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BIS30_05690  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BIS30_05680  serine kinase [KO:K00872] [EC:2.7.1.39]
BIS30_11490  L-threonine synthase [KO:K01733] [EC:4.2.3.1]
BIS30_05685  threonine synthase [KO:K01733] [EC:4.2.3.1]
BIS30_08170  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BIS30_06960  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BIS30_09865  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BIS30_06620  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
BIS30_01195  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BIS30_15715  MFS transporter [KO:K00831] [EC:2.6.1.52]
BIS30_03900  haloacid dehalogenase [KO:K25528] [EC:3.1.3.3]
BIS30_19350  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
BIS30_19345  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BIS30_00055  amine oxidase [KO:K00274] [EC:1.4.3.4]
BIS30_02010  glycine dehydrogenase [KO:K00282] [EC:1.4.4.2]
BIS30_02005  glycine dehydrogenase [KO:K00283] [EC:1.4.4.2]
BIS30_02015  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BIS30_01745  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BIS30_18120  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BIS30_14655  acoL; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BIS30_05995  glycine cleavage system protein H [KO:K02437]
BIS30_02725  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BIS30_11675  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BIS30_05040  alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
BIS30_05045  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BIS30_03010  cystathionine gamma-synthase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
BIS30_18770  serine dehydratase [KO:K01752] [EC:4.3.1.17]
BIS30_18775  serine dehydratase [KO:K01752] [EC:4.3.1.17]
BIS30_00515  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BIS30_01580  serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BIS30_06885  amino acid racemase [KO:K25316] [EC:5.1.1.10]
BIS30_00960  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BIS30_00965  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bit00010  Glycolysis / Gluconeogenesis
bit00020  Citrate cycle (TCA cycle)
bit00230  Purine metabolism
bit00250  Alanine, aspartate and glutamate metabolism
bit00270  Cysteine and methionine metabolism
bit00290  Valine, leucine and isoleucine biosynthesis
bit00300  Lysine biosynthesis
bit00330  Arginine and proline metabolism
bit00460  Cyanoamino acid metabolism
bit00470  D-Amino acid metabolism
bit00564  Glycerophospholipid metabolism
bit00600  Sphingolipid metabolism
bit00620  Pyruvate metabolism
bit00630  Glyoxylate and dicarboxylate metabolism
bit00640  Propanoate metabolism
bit00680  Methane metabolism
bit00860  Porphyrin metabolism
bit00920  Sulfur metabolism
KO pathway
ko00260   
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