KEGG   PATHWAY: bmz00230
Entry
bmz00230                    Pathway                                
Name
Purine metabolism - Brucella melitensis M28
Class
Metabolism; Nucleotide metabolism
Pathway map
bmz00230  Purine metabolism
bmz00230

Module
bmz_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:bmz00230]
bmz_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:bmz00230]
bmz_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:bmz00230]
bmz_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:bmz00230]
bmz_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:bmz00230]
bmz_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:bmz00230]
bmz_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:bmz00230]
Other DBs
GO: 0006163 0042278
Organism
Brucella melitensis M28 [GN:bmz]
Gene
BM28_A0060  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
BM28_A1540  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
BM28_A0468  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
BM28_A0437  purD; Phosphoribosylglycinamide synthetase [KO:K01945] [EC:6.3.4.13]
BM28_A0720  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
BM28_A0846  AIR synthase related protein [KO:K23269] [EC:6.3.5.3]
BM28_A0850  purS; phosphoribosylformylglycinamidine synthase [KO:K23264] [EC:6.3.5.3]
BM28_A0849  phosphoribosylformylglycinamidine synthase [KO:K23265] [EC:6.3.5.3 3.5.1.2]
BM28_A0721  purM; phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
BM28_A1745  purK; phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
BM28_A1744  purE; 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxyl ate (AIR) carboxylase [KO:K01588] [EC:5.4.99.18]
BM28_A0851  purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
BM28_A0856  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
BM28_A1811  purH; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
BM28_A1547  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
BM28_A0893  surE; stationary phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
BM28_A1537  conserved hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
BM28_A1973  Phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
BM28_B0342  inosine 5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
BM28_A0702  Nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
BM28_A0187  Ham1-like protein [KO:K01519] [EC:3.6.1.66]
BM28_A1057  Phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
BM28_A0380  xdhA; xanthine dehydrogenase small subunit [KO:K13481] [EC:1.17.1.4]
BM28_A0381  xdhB; xanthine dehydrogenase molybdopterin binding subunit [KO:K13482] [EC:1.17.1.4]
BM28_B0352  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
BM28_A0385  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
BM28_A0483  Adenylate kinase [KO:K00942] [EC:2.7.4.8]
BM28_B0309  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
BM28_A1053  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
BM28_B0310  nrdF; ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
BM28_A0883  deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
BM28_A0676  putative cytoplasmic protein [KO:K06952] [EC:3.1.3.89]
BM28_A0663  RelA/SpoT family protein [KO:K01139] [EC:2.7.6.5 3.1.7.2]
BM28_B0652  Ppx/GppA phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
BM28_A0761  Ppx/GppA phosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
BM28_A1685  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
BM28_A0638  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
BM28_B0623  adenine deaminase [KO:K01486] [EC:3.5.4.2]
BM28_A1723  Metallo-phosphoesterase [KO:K09769] [EC:3.1.4.16]
BM28_A1223  Adenylate kinase, subfamily [KO:K00939] [EC:2.7.4.3]
BM28_A1077  mazG; nucleoside triphosphate pyrophosphohydrolase [KO:K04765] [EC:3.6.1.9]
BM28_A0205  cysN; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein [KO:K00955] [EC:2.7.7.4 2.7.1.25]
BM28_A0204  sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
BM28_A0526  Transthyretin [KO:K07127] [EC:3.5.2.17]
BM28_A0378  urate catabolism protein [KO:K16842] [EC:3.5.2.5]
BM28_A0377  conserved hypothetical protein [KO:K14977] [EC:3.5.3.26]
BM28_A0525  ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
BM28_A0301  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
BM28_A1370  urease subunit alpha [KO:K01428] [EC:3.5.1.5]
BM28_A0300  ureB; Urease, beta subunit [KO:K01429] [EC:3.5.1.5]
BM28_A1369  urease subunit beta [KO:K01429] [EC:3.5.1.5]
BM28_A0298  ureA; Urease, gamma subunit [KO:K01430] [EC:3.5.1.5]
BM28_A1368  Urease, gamma subunit [KO:K01430] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
bmz00030  Pentose phosphate pathway
bmz00220  Arginine biosynthesis
bmz00250  Alanine, aspartate and glutamate metabolism
bmz00260  Glycine, serine and threonine metabolism
bmz00340  Histidine metabolism
bmz00630  Glyoxylate and dicarboxylate metabolism
bmz00730  Thiamine metabolism
bmz00740  Riboflavin metabolism
bmz00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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