KEGG   PATHWAY: bpec04145
Entry
bpec04145                   Pathway                                
Name
Phagosome - Boleophthalmus pectinirostris (great blue-spotted mudskipper)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
bpec04145  Phagosome
bpec04145

Other DBs
GO: 0045335
Organism
Boleophthalmus pectinirostris (great blue-spotted mudskipper) [GN:bpec]
Gene
110168441  vesicle-associated membrane protein 3-like isoform X1 [KO:K13505]
110167318  syntaxin-12-like [KO:K13813]
110172804  syntaxin-12-like [KO:K13813]
110155058  syntaxin-7-like [KO:K08488]
110162397  actb; actin, cytoplasmic 1 isoform X1 [KO:K05692]
110153521  actin, cytoplasmic 1 [KO:K05692]
110167724  coronin-1A-like [KO:K13882]
110154643  stx18; syntaxin-18 [KO:K08492]
110174063  vesicle-trafficking protein SEC22b-B isoform X1 [KO:K08517]
110173456  vesicle-trafficking protein SEC22b-like isoform X1 [KO:K08517]
110173293  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
110173294  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110162091  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110156500  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
110156519  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110163865  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110163323  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110170315  major histocompatibility complex class I-related gene protein-like [KO:K06751]
110173272  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110172530  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110171680  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
110165497  H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752]
110171530  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
110171550  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
110172806  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
110172816  H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752]
110171212  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
110171611  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
110171630  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
110166073  H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752]
110175549  ras-related protein Rab-5A-like [KO:K07887]
110167156  ras-related protein Rab-5A [KO:K07887]
110170657  ras-related protein Rab-5C-like [KO:K07888]
110154185  ras-related protein Rab-5C-like [KO:K07889]
110161503  rab5c; ras-related protein Rab-5C [KO:K07889]
110165609  eea1; early endosome antigen 1 [KO:K12478]
110171971  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
110173509  tfrc; transferrin receptor protein 1 [KO:K06503]
110161276  transferrin receptor protein 1-like [KO:K06503]
110166460  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
110160930  atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
110169129  V-type proton ATPase subunit B, brain isoform [KO:K02147]
110155351  V-type proton ATPase subunit C 1-B-like [KO:K02148]
110171694  atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
110167424  V-type proton ATPase subunit C 1-A [KO:K02148]
110164275  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
110169605  V-type proton ATPase subunit E 1-like [KO:K02150]
110161719  atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
110161815  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
110175792  V-type proton ATPase subunit G 1-like [KO:K02152]
110155947  V-type proton ATPase subunit e 2-like [KO:K02153]
110169961  atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
110160674  tcirg1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
110154262  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
110160506  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
110159496  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
110164361  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
110173394  V-type proton ATPase subunit d 1-like [KO:K02146]
110170841  protein regulator of cytokinesis 1-like [KO:K02146]
110164167  atp6v1h; V-type proton ATPase subunit H [KO:K02144]
110159651  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
110158207  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
110164131  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
110169977  atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
110154015  V-type proton ATPase subunit S1-like [KO:K03662]
110165695  ras-related protein rab7 [KO:K07897]
110170175  ras-related protein Rab-7a-like [KO:K07897]
110154101  RILP-like protein 1 [KO:K13883]
110161350  dync1h1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
110174246  dync2h1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
110173382  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
110166604  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
110167285  LOW QUALITY PROTEIN: cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
110172872  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
110164508  tubulin alpha-8 chain-like [KO:K07374]
110156161  tubulin alpha chain isoform X1 [KO:K07374]
110156162  tubulin alpha chain-like [KO:K07374]
110165552  tubulin alpha-1C chain-like [KO:K07374]
110157866  tubulin alpha-1B chain-like [KO:K07374]
110153998  tubulin alpha-1B chain-like [KO:K07374]
110154010  tubulin alpha-1B chain-like [KO:K07374]
110154011  tubulin alpha-1A chain isoform X1 [KO:K07374]
110154012  tubulin alpha-1C chain-like [KO:K07374]
110165998  tuba4a; tubulin alpha-4A chain [KO:K07374]
110154657  LOW QUALITY PROTEIN: tubulin beta-1 chain-like [KO:K07375]
110166266  tubulin beta-4B chain-like isoform X1 [KO:K07375]
110170267  tubulin beta-6 chain isoform X1 [KO:K07375]
110155218  tubulin beta-4B chain isoform X1 [KO:K07375]
110158922  tubulin beta chain-like isoform X1 [KO:K07375]
110168860  tubulin beta chain-like [KO:K07375]
110166185  tubulin beta-4B chain-like isoform X1 [KO:K07375]
110162456  LOW QUALITY PROTEIN: tubulin beta chain-like [KO:K07375]
110172867  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
110158874  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
110173206  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
110170588  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
110163027  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
110155016  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
110160872  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
110157001  ctsl; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
110154701  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
110162666  cathepsin K-like [KO:K01368] [EC:3.4.22.27]
110162667  cathepsin L1-like [KO:K01368] [EC:3.4.22.27]
110162671  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
110168875  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
110168941  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
110168378  protein transport protein Sec61 subunit alpha-like [KO:K10956]
110171115  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
110171691  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
110161010  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
110171064  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
110173278  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
110154207  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
110164082  calreticulin-like isoform X1 [KO:K08057]
110160209  calreticulin-like [KO:K08057]
110165500  calnexin-like [KO:K08054]
110163648  low affinity immunoglobulin gamma Fc region receptor IV-like [KO:K06498]
110172767  low affinity immunoglobulin gamma Fc region receptor II-a-like [KO:K06472]
110159543  integrin alpha-D-like [KO:K06461]
110159544  integrin alpha-D-like [KO:K06461]
110165161  integrin beta-2-like [KO:K06464]
110166125  LOW QUALITY PROTEIN: complement C3-like [KO:K03990]
110155577  colec11; collectin-11 isoform X1 [KO:K10066]
110164127  collectin-12-like [KO:K10062]
110170011  colec12; collectin-12 [KO:K10062]
110162930  itgav; integrin alpha-V [KO:K06487]
110172107  itga2; integrin alpha-2 [KO:K06481]
110164578  integrin alpha-5-like [KO:K06484]
110165784  integrin alpha-5-like [KO:K06484]
110165515  itgb1; integrin beta-1 [KO:K05719]
110161461  integrin beta-3-like [KO:K06493]
110154280  itgb3; integrin beta-3 [KO:K06493]
110170582  itgb5; integrin beta-5 [KO:K06588]
110155241  thrombospondin-1-like [KO:K16857]
110172375  thrombospondin-1-like [KO:K16857]
110157347  thrombospondin-4-B-like [KO:K04659]
110174600  thrombospondin-2-like [KO:K04659]
110157882  thbs3; thrombospondin-3 [KO:K04659]
110156952  thbs2; thrombospondin-2 [KO:K04659]
110167973  comp; cartilage oligomeric matrix protein [KO:K04659]
110156670  thrombospondin-4-B-like isoform X1 [KO:K04659]
110160272  toll-like receptor 2 type-2 [KO:K10159]
110170449  toll-like receptor 2 [KO:K10159]
110164151  macrophage mannose receptor 1-like [KO:K06560]
110170031  mrc1; macrophage mannose receptor 1 [KO:K06560]
110173031  pla2r1; secretory phospholipase A2 receptor [KO:K06560]
110161494  LOW QUALITY PROTEIN: C-type mannose receptor 2-like [KO:K06560]
110174760  macrophage receptor MARCO-like [KO:K13884]
110166692  scarb1; scavenger receptor class B member 1 [KO:K13885]
110161478  cd36; platelet glycoprotein 4 [KO:K06259]
110175258  cytochrome b-245 light chain [KO:K08009]
110156598  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
110159668  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110166971  ncf1; neutrophil cytosol factor 1 [KO:K08011]
110165371  neutrophil cytosol factor 2-like [KO:K08010]
110168243  ncf4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
bpec04142  Lysosome
bpec04144  Endocytosis
bpec04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
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