KEGG   PATHWAY: bpm00260
Entry
bpm00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia pseudomallei 1710b
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bpm00260  Glycine, serine and threonine metabolism
bpm00260

Module
bpm_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bpm00260]
bpm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bpm00260]
bpm_M00555  Betaine biosynthesis, choline => betaine [PATH:bpm00260]
bpm_M00621  Glycine cleavage system [PATH:bpm00260]
bpm_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bpm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia pseudomallei 1710b [GN:bpm]
Gene
BURPS1710b_2677  ask; aspartokinase, alpha and beta subunits [KO:K00928] [EC:2.7.2.4]
BURPS1710b_A0773  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BURPS1710b_2396  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BURPS1710b_A0859  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
BURPS1710b_2395  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BURPS1710b_2159  Beta-eliminating lyase [KO:K01620] [EC:4.1.2.48]
BURPS1710b_A1771  ltaE; L-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BURPS1710b_3250  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BURPS1710b_A2106  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BURPS1710b_0544  unnamed protein product [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BURPS1710b_2286  tkrA; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BURPS1710b_2926  glyoxylate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BURPS1710b_A1637  glxK; glycerate kinase 1 [KO:K00865] [EC:2.7.1.165]
BURPS1710b_2484  glxK; glycerate kinase 1 [KO:K00865] [EC:2.7.1.165]
BURPS1710b_0662  gpmA; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
BURPS1710b_3410  gpmB; phosphoglycerate mutase 2 [KO:K15634] [EC:5.4.2.11]
BURPS1710b_0341  serA1; D-isomer specific 2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BURPS1710b_1481  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BURPS1710b_2998  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BURPS1710b_2651  serC-2; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BURPS1710b_2322  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
BURPS1710b_3251  putative short-chain dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BURPS1710b_A1510  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
BURPS1710b_A1512  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BURPS1710b_0129  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
BURPS1710b_0127  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
BURPS1710b_2743  lpdA; pyruvate dehydrogenase, E3 component, dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BURPS1710b_A1408  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BURPS1710b_1926  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BURPS1710b_0128  gcvH; glycine cleavage system H protein [KO:K02437]
BURPS1710b_1423  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferse [KO:K17103] [EC:2.7.8.8]
BURPS1710b_A0377  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BURPS1710b_A0376  betB; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BURPS1710b_A2115  iron-sulphur Rieske protein [KO:K00479] [EC:1.14.13.251]
BURPS1710b_A2116  iron-sulfur cluster-binding protein [KO:K21832] [EC:1.14.13.251]
BURPS1710b_A2110  stcD; oxidoreductase, FAD/FMN-binding [KO:K21833] [EC:1.5.7.3]
BURPS1710b_A2111  iron-sulfur cluster binding protein [KO:K21834]
BURPS1710b_A2112  eftA; electron transfer flavoprotein, alpha subunit [KO:K25960]
BURPS1710b_A2113  eftB; electron transfer flavoprotein, beta subunit [KO:K25961]
BURPS1710b_A0393  soxA; putative sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
BURPS1710b_A0395  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
BURPS1710b_A0392  soxG; sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
BURPS1710b_A0394  soxD; sarcosine oxidase, delta chain [KO:K00304] [EC:1.5.3.24 1.5.3.1]
BURPS1710b_A0396  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BURPS1710b_0131  sdaA; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BURPS1710b_A0284  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BURPS1710b_0840  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
BURPS1710b_2515  tdcB; threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
BURPS1710b_0834  dsd; D-serine deaminase [KO:K01753] [EC:4.3.1.18]
BURPS1710b_A1220  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
BURPS1710b_A0767  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
BURPS1710b_A0769  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
BURPS1710b_A0697  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
BURPS1710b_0696  rhbA; diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bpm00010  Glycolysis / Gluconeogenesis
bpm00020  Citrate cycle (TCA cycle)
bpm00230  Purine metabolism
bpm00250  Alanine, aspartate and glutamate metabolism
bpm00270  Cysteine and methionine metabolism
bpm00290  Valine, leucine and isoleucine biosynthesis
bpm00300  Lysine biosynthesis
bpm00330  Arginine and proline metabolism
bpm00460  Cyanoamino acid metabolism
bpm00470  D-Amino acid metabolism
bpm00564  Glycerophospholipid metabolism
bpm00600  Sphingolipid metabolism
bpm00620  Pyruvate metabolism
bpm00630  Glyoxylate and dicarboxylate metabolism
bpm00640  Propanoate metabolism
bpm00680  Methane metabolism
bpm00860  Porphyrin metabolism
bpm00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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