KEGG   PATHWAY: cabi03083
Entry
cabi03083                   Pathway                                
Name
Polycomb repressive complex - Chelonoidis abingdonii (Abingdon island giant tortoise)
Class
Genetic Information Processing; Chromosome
Pathway map
cabi03083  Polycomb repressive complex
cabi03083

Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]
Gene
116814617  ASXL2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
116814641  ASXL1; polycomb group protein ASXL1 isoform X1 [KO:K11471]
116815116  FBRS; LOW QUALITY PROTEIN: probable fibrosin-1 [KO:K26253]
116815245  SCML2; sex comb on midleg-like protein 2 isoform X1 [KO:K11465]
116815273  YY1; transcriptional repressor protein YY1 [KO:K09201]
116815561  EED; polycomb protein EED [KO:K11462]
116815575  SCMH1; polycomb protein SCMH1 isoform X1 [KO:K11461]
116816562  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
116817206  PCGF3; polycomb group RING finger protein 3 isoform X1 [KO:K11488]
116817423  WDR5; WD repeat-containing protein 5 isoform X1 [KO:K14963]
116817451  PHF19; PHD finger protein 19 isoform X1 [KO:K11486]
116817565  FOXK1; LOW QUALITY PROTEIN: forkhead box protein K1 [KO:K09404]
116818112  PCGF5; polycomb group RING finger protein 5 isoform X1 [KO:K11489]
116818610  L3MBTL1; lethal(3)malignant brain tumor-like protein 1 isoform X1 [KO:K24387]
116818849  MBD6; methyl-CpG-binding domain protein 6 [KO:K26585]
116819456  FBRSL1; fibrosin-1-like protein isoform X1 [KO:K26254]
116820263  JARID2; protein Jumonji [KO:K11478]
116820359  EZH1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
116820496  MTF2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
116820675  SFMBT2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
116820993  CBX3; chromobox protein homolog 3 isoform X1 [KO:K11586]
116821253  RBBP7; histone-binding protein RBBP7 [KO:K11659]
116822062  BMI1; polycomb complex protein BMI-1 [KO:K11459]
116822173  MAX; protein max isoform X1 [KO:K04453]
116822861  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
116823250  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
116823341  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
116823403  [KO:K14827]
116823847  PHC1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
116824427  USP16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
116824608  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
116824665  USP45; ubiquitin carboxyl-terminal hydrolase 45 [KO:K11844] [EC:3.4.19.12]
116825530  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
116825808  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
116826103  [KO:K11479] [EC:2.7.11.1]
116826293  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
116826357  [KO:K26260]
116826371  LCOR; ligand-dependent corepressor [KO:K26260]
116826622  RNF2; E3 ubiquitin-protein ligase RING2 [KO:K10695] [EC:2.3.2.27]
116826640  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
116826751  PHC3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
116828013  BCORL1; BCL-6 corepressor-like protein 1 [KO:K26199]
116828080  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
116828097  PCGF6; polycomb group RING finger protein 6 isoform X1 [KO:K11470]
116829026  L3MBTL2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
116829048  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
116829130  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
116829153  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
116829497  PHF1; PHD finger protein 1 [KO:K11467]
116829513  RING1; E3 ubiquitin-protein ligase RING1 [KO:K10695] [EC:2.3.2.27]
116830644  CBX7; chromobox protein homolog 7 isoform X1 [KO:K11454]
116830647  CBX6; chromobox protein homolog 6 isoform X1 [KO:K11453]
116831060  [KO:K24387]
116831166  AUTS2; autism susceptibility gene 2 protein isoform X1 [KO:K23214]
116831406  PCGF2; polycomb group RING finger protein 2 isoform X1 [KO:K11460]
116831410  EPOP; elongin BC and Polycomb repressive complex 2-associated protein [KO:K26259]
116831437  BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [KO:K08588] [EC:3.4.19.12]
116831629  MBD5; methyl-CpG-binding domain protein 5 isoform X1 [KO:K23219]
116831962  E2F6; transcription factor E2F6 isoform X1 [KO:K09390]
116832200  FOXK2; forkhead box protein K2 isoform X1 [KO:K09404]
116832656  PCGF1; polycomb group RING finger protein 1 [KO:K11487]
116832812  MGA; MAX gene-associated protein isoform X1 [KO:K23399]
116832838  OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
116833413  KDM2A; lysine-specific demethylase 2A isoform X1 [KO:K10276] [EC:1.14.11.27]
116833978  BCOR; BCL-6 corepressor isoform X1 [KO:K23215]
116834111  RYBP; RING1 and YY1-binding protein [KO:K11469]
116834141  AEBP2; zinc finger protein AEBP2 isoform X1 [KO:K17452]
116834831  CBX4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
116834832  CBX8; chromobox protein homolog 8 [KO:K11455]
116834870  CBX2; chromobox protein homolog 2 [KO:K11451]
116835567  PHC2; polyhomeotic-like protein 2 isoform X1 [KO:K11457]
116836761  KDM2B; lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
116837887  ASXL3; putative Polycomb group protein ASXL3 isoform X1 [KO:K11471]
116837910  [KO:K24387]
116838978  YAF2; YY1-associated factor 2 [KO:K11468]
116839494  DCAF7; DDB1- and CUL4-associated factor 7 [KO:K11805]
116839590  SUZ12; polycomb protein SUZ12 isoform X1 [KO:K11463]
116839660  AURKB; aurora kinase B [KO:K11479] [EC:2.7.11.1]
116839700  SFMBT1; scm-like with four MBT domains protein 1 [KO:K26269]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   

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