KEGG   PATHWAY: care00260
Entry
care00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Collimonas arenae
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
care00260  Glycine, serine and threonine metabolism
care00260

Module
care_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:care00260]
care_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:care00260]
care_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:care00260]
care_M00555  Betaine biosynthesis, choline => betaine [PATH:care00260]
care_M00621  Glycine cleavage system [PATH:care00260]
care_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:care00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Collimonas arenae [GN:care]
Gene
LT85_2308  Aspartokinase [KO:K00928] [EC:2.7.2.4]
LT85_2750  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LT85_2162  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
LT85_0795  Homoserine kinase [KO:K02204] [EC:2.7.1.39]
LT85_2357  Threonine synthase [KO:K01733] [EC:4.2.3.1]
LT85_2056  Low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
LT85_3891  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LT85_1454  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LT85_0048  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
LT85_4848  D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
LT85_1512  Glyoxylate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
LT85_3979  D-glycerate 2-kinase [KO:K11529] [EC:2.7.1.165]
LT85_4618  Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
LT85_4507  hypothetical protein [KO:K15634] [EC:5.4.2.11]
LT85_4988  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LT85_4301  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
LT85_2867  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
LT85_3893  3-hydroxypropionate dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
LT85_1871  8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
LT85_2047  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
LT85_2614  Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) [KO:K00281] [EC:1.4.4.2]
LT85_2613  Aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
LT85_4069  Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex [KO:K00382] [EC:1.8.1.4]
LT85_2893  Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase [KO:K00382] [EC:1.8.1.4]
LT85_2615  Glycine cleavage system H protein [KO:K02437]
LT85_3275  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
LT85_3500  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
LT85_3660  Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
LT85_3661  Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LT85_1461  Benzoate 1,2-dioxygenase [KO:K00479] [EC:1.14.13.251]
LT85_1462  Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [KO:K21832] [EC:1.14.13.251]
LT85_1457  dgcA; DgcA Dimethylglycine demethylase subunit A [KO:K21833] [EC:1.5.7.3]
LT85_1458  Iron-sulfur cluster-binding protein [KO:K21834]
LT85_1459  Electron transfer flavoprotein [KO:K25960]
LT85_1460  Electron transfer flavoprotein [KO:K25961]
LT85_1485  Sarcosine oxidase alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
LT85_1483  Sarcosine oxidase beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
LT85_1486  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
LT85_1484  Sarcosine oxidase delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]
LT85_3220  Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
LT85_3219  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
LT85_1482  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
LT85_0685  Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
LT85_4864  Threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LT85_1332  Aspartate racemase [KO:K25316] [EC:5.1.1.10]
LT85_2745  Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
LT85_2746  Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
care00010  Glycolysis / Gluconeogenesis
care00020  Citrate cycle (TCA cycle)
care00230  Purine metabolism
care00250  Alanine, aspartate and glutamate metabolism
care00270  Cysteine and methionine metabolism
care00290  Valine, leucine and isoleucine biosynthesis
care00300  Lysine biosynthesis
care00330  Arginine and proline metabolism
care00460  Cyanoamino acid metabolism
care00470  D-Amino acid metabolism
care00564  Glycerophospholipid metabolism
care00620  Pyruvate metabolism
care00630  Glyoxylate and dicarboxylate metabolism
care00640  Propanoate metabolism
care00680  Methane metabolism
care00860  Porphyrin metabolism
care00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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