KEGG   PATHWAY: caty00564
Entry
caty00564                   Pathway                                
Name
Glycerophospholipid metabolism - Cercocebus atys (sooty mangabey)
Class
Metabolism; Lipid metabolism
Pathway map
caty00564  Glycerophospholipid metabolism
caty00564

Module
caty_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:caty00564]
caty_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:caty00564]
caty_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:caty00564]
Other DBs
GO: 0006650
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105571409  SGMS2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
105571417  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
105571426  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105571913  DGKK; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
105572203  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105572600  MBOAT1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
105573314  CHPT1; cholinephosphotransferase 1 isoform X1 [KO:K00994] [EC:2.7.8.2]
105573940  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
105574094  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X1 [KO:K13509] [EC:2.3.1.51]
105574211  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574213  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
105574214  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574265  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105574608  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
105574850  GNPAT; dihydroxyacetone phosphate acyltransferase isoform X1 [KO:K00649] [EC:2.3.1.42]
105575118  PCYT1A; choline-phosphate cytidylyltransferase A isoform X1 [KO:K00968] [EC:2.7.7.15]
105575259  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
105575508  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105575741  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105575752  PISD; phosphatidylserine decarboxylase proenzyme isoform X1 [KO:K01613] [EC:4.1.1.65]
105575872  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
105576003  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
105576023  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
105576785  CDS1; phosphatidate cytidylyltransferase 1 isoform X1 [KO:K00981] [EC:2.7.7.41]
105576789  AGPAT9; glycerol-3-phosphate acyltransferase 3 isoform X1 [KO:K13506] [EC:2.3.1.15]
105577121  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
105577196  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
105577333  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
105577518  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105577519  HRASLS2; HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105577644  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
105577901  GPAM; LOW QUALITY PROTEIN: glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
105577982  PPAPDC1A; phosphatidate phosphatase PPAPDC1A isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
105578415  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
105578433  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
105578501  EPT1; ethanolaminephosphotransferase 1 isoform X1 [KO:K00993] [EC:2.7.8.1]
105578618  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
105579465  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
105579733  TAZ; tafazzin isoform X1 [KO:K13511] [EC:2.3.1.-]
105579889  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105580359  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
105580577  AGPAT2; LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
105580667  PNPLA7; LOW QUALITY PROTEIN: patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
105581448  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
105582101  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
105582107  GPCPD1; LOW QUALITY PROTEIN: glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
105582113  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
105583048  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
105583288  DGKE; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
105583465  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
105583725  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
105583803  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
105583958  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
105584453  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
105585053  ETNK1; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
105585326  LCAT; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
105585504  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
105586073  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
105586505  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
105586863  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
105587181  SGMS1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
105587318  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
105587546  MBOAT2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
105587814  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
105588407  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
105588546  LPCAT2; lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
105588586  PCYT2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
105589146  PNPLA6; neuropathy target esterase isoform X1 [KO:K14676] [EC:3.1.1.5]
105589572  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
105589636  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
105589731  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
105590793  PPAPDC1B; phosphatidate phosphatase PPAPDC1B isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
105590935  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105591468  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
105591642  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
105591665  PPAP2C; lipid phosphate phosphohydrolase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
105592144  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
105592794  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
105594201  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [KO:K19007] [EC:2.3.1.51]
105594237  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
105594376  CEPT1; choline/ethanolaminephosphotransferase 1 isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
105594992  LYPLA2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
105595050  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105595052  PLA2G5; calcium-dependent phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105595053  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105595054  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105595055  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
105595056  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105595443  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
105595682  MBOAT7; LOW QUALITY PROTEIN: lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
105595768  AGPAT6; glycerol-3-phosphate acyltransferase 6 isoform X1 [KO:K13506] [EC:2.3.1.15]
105595985  PPAP2B; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
105596774  PLD4; phospholipase D4 [KO:K16860] [EC:3.1.4.4]
105597315  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
105597359  SAMD8; sphingomyelin synthase-related protein 1 isoform X1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
105597707  PPAP2A; lipid phosphate phosphohydrolase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
105597974  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
105598196  PEMT; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
105599008  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
105600634  LPCAT4; lysophospholipid acyltransferase LPCAT4 isoform X1 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
105600708  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
caty00010  Glycolysis / Gluconeogenesis
caty00260  Glycine, serine and threonine metabolism
caty00561  Glycerolipid metabolism
caty00562  Inositol phosphate metabolism
caty00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
caty00565  Ether lipid metabolism
caty00620  Pyruvate metabolism
KO pathway
ko00564   

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