KEGG   PATHWAY: cgib00480
Entry
cgib00480                   Pathway                                
Name
Glutathione metabolism - Carassius gibelio (silver crucian carp)
Class
Metabolism; Metabolism of other amino acids
Pathway map
cgib00480  Glutathione metabolism
cgib00480

Module
cgib_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:cgib00480]
Other DBs
GO: 0006749
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127944693  glutathione hydrolase 7-like [KO:K00681] [EC:2.3.2.2 3.4.19.13]
128000089  si:ch73-337l15.2; glutathione hydrolase 6 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
128011404  glutathione hydrolase 7 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
127980758  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127964066  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127966010  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127966011  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127948937  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
128018430  LOW QUALITY PROTEIN: gamma-glutamyltransferase 1a [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
128018431  gamma-glutamyltransferase 5a isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
128020700  glutathione hydrolase 5 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
127974506  gamma-glutamylcyclotransferase b [KO:K00682] [EC:4.3.2.9]
127935239  gamma-glutamylcyclotransferase a [KO:K00682] [EC:4.3.2.9]
127983709  glutathione-specific gamma-glutamylcyclotransferase 1-like [KO:K07232] [EC:4.3.2.7]
127938025  glutathione-specific gamma-glutamylcyclotransferase 1 [KO:K07232] [EC:4.3.2.7]
127968847  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
128024901  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
127970321  glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
128026724  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
127963648  glutamate--cysteine ligase regulatory subunit [KO:K11205]
128018849  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
127944445  glutathione synthetase [KO:K21456] [EC:6.3.2.3]
127963434  cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
127963235  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
128018411  putative aminopeptidase W07G4.4 [KO:K01255] [EC:3.4.11.1]
127961801  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
127961802  aminopeptidase Ey [KO:K11140] [EC:3.4.11.2]
127947014  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
127947016  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
128014468  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
128017330  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
127970546  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127970790  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
127962947  glutathione S-transferase theta-1a [KO:K00799] [EC:2.5.1.18]
127963074  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
127963076  glutathione S-transferase mu tandem duplicate 3 [KO:K00799] [EC:2.5.1.18]
127956643  microsomal glutathione S-transferase 1.1 [KO:K00799] [EC:2.5.1.18]
127956644  microsomal glutathione S-transferase 1.2 [KO:K00799] [EC:2.5.1.18]
127957338  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
127935227  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127969658  glutathione S-transferase, alpha tandem duplicate 1 [KO:K00799] [EC:2.5.1.18]
127941348  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
127969936  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
127978687  glutathione S-transferase A-like isoform X1 [KO:K00799] [EC:2.5.1.18]
127978688  glutathione S-transferase A-like [KO:K00799] [EC:2.5.1.18]
128014238  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
127984541  microsomal glutathione S-transferase 3a [KO:K00799] [EC:2.5.1.18]
127986609  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
128025910  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128026206  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
128026562  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
128018639  glutathione S-transferase Mu 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128027540  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
127971698  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
128027703  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
127975161  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
127975162  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
127975247  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
128030575  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
127989613  glutathione S-transferase LANCL1 isoform X1 [KO:K25210] [EC:2.5.1.18]
127969742  probable N-acetyltransferase CML1 [KO:K20838] [EC:2.3.1.80 2.3.1.-]
128016029  probable N-acetyltransferase camello [KO:K20838] [EC:2.3.1.80 2.3.1.-]
128016031  probable N-acetyltransferase camello [KO:K20838] [EC:2.3.1.80 2.3.1.-]
128026325  probable N-acetyltransferase camello [KO:K20838] [EC:2.3.1.80 2.3.1.-]
127971564  glutathione reductase-like isoform X1 [KO:K00383] [EC:1.8.1.7]
128027461  glutathione reductase-like isoform X1 [KO:K00383] [EC:1.8.1.7]
127965502  isocitrate dehydrogenase [NADP] cytoplasmic isoform X1 [KO:K00031] [EC:1.1.1.42]
127934204  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
127977167  isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
128019842  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
127945112  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
128011963  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
127944567  glucose-6-phosphate 1-dehydrogenase-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
128011261  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
127950788  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
128026161  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
127951669  phospholipid hydroperoxide glutathione peroxidase [KO:K05361] [EC:1.11.1.12]
127943422  glutathione peroxidase 4a isoform X1 [KO:K05361] [EC:1.11.1.12]
127938347  phospholipid hydroperoxide glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
127970945  glutathione peroxidase 3-like [KO:K00432] [EC:1.11.1.9]
127967851  glutathione peroxidase 1a [KO:K00432] [EC:1.11.1.9]
127975860  glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
127959042  glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
128025526  glutathione peroxidase 9 [KO:K00432] [EC:1.11.1.9]
128018429  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
128011050  glutathione peroxidase 7-like [KO:K00432] [EC:1.11.1.9]
128011890  glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
127938934  peroxiredoxin-6 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
128022271  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
127984347  peroxiredoxin-6-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
127976013  ornithine decarboxylase isoform X1 [KO:K01581] [EC:4.1.1.17]
128031383  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
127945000  spermidine synthase [KO:K00797] [EC:2.5.1.16]
128012205  spermidine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
127941692  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
127946543  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
127986462  spermine synthase [KO:K00802] [EC:2.5.1.22]
127942045  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
127986385  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
127935085  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
127938948  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
127978554  ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
127984438  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
cgib00220  Arginine biosynthesis
cgib00250  Alanine, aspartate and glutamate metabolism
cgib00270  Cysteine and methionine metabolism
cgib00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

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