KEGG   PATHWAY: cgib00270
Entry
cgib00270                   Pathway                                
Name
Cysteine and methionine metabolism - Carassius gibelio (silver crucian carp)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
cgib00270  Cysteine and methionine metabolism
cgib00270

Module
cgib_M00034  Methionine salvage pathway [PATH:cgib00270]
cgib_M00035  Methionine degradation [PATH:cgib00270]
cgib_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cgib00270]
Other DBs
GO: 0006534 0006555
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127959445  cystathionine gamma-lyase-like isoform X1 [KO:K01758] [EC:4.4.1.1]
128015702  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
127958381  kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
127959853  kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
128006332  kynurenine--oxoglutarate transaminase 1-like [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
127965317  cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
127949645  cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]
128015386  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
127942096  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
127986306  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
128015588  zgc:172121; homocysteine S-methyltransferase YbgG isoform X1 [KO:K00547] [EC:2.1.1.10]
128025592  methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
127941653  methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
127966171  methionine adenosyltransferase II, alpha a [KO:K00789] [EC:2.5.1.6]
127958003  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
127970226  S-adenosylmethionine synthase-like isoform X1 [KO:K00789] [EC:2.5.1.6]
128021375  S-adenosylmethionine synthase-like isoform X1 [KO:K00789] [EC:2.5.1.6]
128021449  methionine adenosyltransferase II, alpha-like isoform X1 [KO:K00789] [EC:2.5.1.6]
127985659  methionine adenosyltransferase 2 subunit beta-like isoform X1 [KO:K00789] [EC:2.5.1.6]
128026396  S-adenosylmethionine synthase-like isoform X1 [KO:K00789] [EC:2.5.1.6]
127938320  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
127984368  LOW QUALITY PROTEIN: S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
127945000  spermidine synthase [KO:K00797] [EC:2.5.1.16]
128012205  spermidine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
127941692  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
127946543  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
127986462  spermine synthase [KO:K00802] [EC:2.5.1.22]
127951180  S-methyl-5'-thioadenosine phosphorylase-like [KO:K00772] [EC:2.4.2.28]
127948891  S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
128019515  purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
127949506  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
128019480  methylthioribose-1-phosphate isomerase-like [KO:K08963] [EC:5.3.1.23]
127962565  methylthioribulose-1-phosphate dehydratase-like [KO:K08964] [EC:4.2.1.109]
128016602  methylthioribulose-1-phosphate dehydratase isoform X1 [KO:K08964] [EC:4.2.1.109]
127966841  enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
127976285  acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
127934260  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
127977307  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
127972193  L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
128029454  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
127975850  glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
128031492  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
127952535  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
127953297  DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
127983577  DNA (cytosine-5-)-methyltransferase 3 alpha a isoform X1 [KO:K17398] [EC:2.1.1.37]
127933288  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
127976610  DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
127938552  DNA (cytosine-5)-methyltransferase 3A-like [KO:K17398] [EC:2.1.1.37]
127963730  DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1 [KO:K17399] [EC:2.1.1.37]
127944572  uncharacterized protein LOC127944572 isoform X1 [KO:K17399] [EC:2.1.1.37]
127945015  DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]
128018690  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17399] [EC:2.1.1.37]
128011364  uncharacterized protein LOC128011364 [KO:K17399] [EC:2.1.1.37]
128019168  DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]
128011623  DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
127963758  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
127956833  adenosylhomocysteinase like 2b [KO:K01251] [EC:3.13.2.1]
127947467  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
127960067  adenosylhomocysteinase B [KO:K01251] [EC:3.13.2.1]
127977897  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
128013810  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
128015943  adenosylhomocysteinase B-like [KO:K01251] [EC:3.13.2.1]
128018650  S-adenosylhomocysteine hydrolase-like protein 1 [KO:K01251] [EC:3.13.2.1]
127953658  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
127956780  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
127974905  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
127949023  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
127942278  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127986039  alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127970321  glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
128026724  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
127963648  glutamate--cysteine ligase regulatory subunit [KO:K11205]
128018849  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
127944445  glutathione synthetase [KO:K21456] [EC:6.3.2.3]
127963726  cysteine dioxygenase type 1-like [KO:K00456] [EC:1.13.11.20]
128019126  cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
127970390  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
128025968  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
128018361  putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
127962559  glutamic-oxaloacetic transaminase 2b, mitochondrial [KO:K14455] [EC:2.6.1.1]
127934555  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
127977788  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
128017742  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
127945858  3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
127956188  L-lactate dehydrogenase B-A chain-like [KO:K00016] [EC:1.1.1.27]
127946726  L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
127975042  L-lactate dehydrogenase B-A chain [KO:K00016] [EC:1.1.1.27]
127947017  L-lactate dehydrogenase B-B chain isoform X1 [KO:K00016] [EC:1.1.1.27]
128014031  LOW QUALITY PROTEIN: L-lactate dehydrogenase B-B chain [KO:K00016] [EC:1.1.1.27]
128014116  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
127975785  malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
127949004  malate dehydrogenase 1Aa, NAD (soluble) isoform X1 [KO:K00025] [EC:1.1.1.37]
128020941  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
127966452  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
128021072  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
127975941  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
127964598  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
128020083  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
127958004  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
127990195  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
cgib00010  Glycolysis / Gluconeogenesis
cgib00250  Alanine, aspartate and glutamate metabolism
cgib00260  Glycine, serine and threonine metabolism
cgib00290  Valine, leucine and isoleucine biosynthesis
cgib00430  Taurine and hypotaurine metabolism
cgib00480  Glutathione metabolism
cgib00620  Pyruvate metabolism
cgib00640  Propanoate metabolism
cgib00770  Pantothenate and CoA biosynthesis
cgib00900  Terpenoid backbone biosynthesis
cgib00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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