KEGG   PATHWAY: cmk03320
Entry
cmk03320                    Pathway                                
Name
PPAR signaling pathway - Callorhinchus milii (elephant shark)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
cmk03320  PPAR signaling pathway
cmk03320

Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103177004  platelet glycoprotein 4 [KO:K06259]
103183068  slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
103186490  very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103178046  long-chain fatty acid transport protein 6 [KO:K08749]
103181509  fatty acid-binding protein, liver-like [KO:K08750]
103181510  fatty acid-binding protein, liver-like [KO:K08750]
103181460  fatty acid-binding protein, liver-like [KO:K08750]
103181512  fatty acid-binding protein 1, liver [KO:K08750]
103177367  fabp2; fatty acid-binding protein, intestinal [KO:K08751]
103185843  fatty acid-binding protein, intestinal isoform X2 [KO:K08751]
103179615  fatty acid-binding protein, heart isoform X1 [KO:K08752]
103180749  fatty acid-binding protein, heart-like [KO:K08752]
103180750  fatty acid-binding protein, heart-like [KO:K08752]
103186487  gastrotropin-like [KO:K08755]
103186488  gastrotropin-like [KO:K08755]
103182315  fabp7b; fatty acid binding protein 7, brain, b [KO:K08756]
121848014  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
103184713  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
103184778  retinoic acid receptor RXR-gamma-A isoform X1 [KO:K08526]
103179054  peroxisome proliferator-activated receptor delta [KO:K04504]
103185017  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
103173382  hmgcs1; LOW QUALITY PROTEIN: hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
103187698  apolipoprotein A-I [KO:K08757]
103173059  phospholipid transfer protein isoform X1 [KO:K08761]
103184403  NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
103178308  me1; NADP-dependent malic enzyme isoform X2 [KO:K00029] [EC:1.1.1.40]
103174861  acyl-CoA 6-desaturase [KO:K10226] [EC:1.14.19.3]
103182461  acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
103175777  stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
103180710  cytochrome P450 7A1 [KO:K00489] [EC:1.14.14.23]
103188298  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
103189020  si:dkey-91i10.3; cytochrome P450 [KO:K00488] [EC:1.14.15.15]
103180359  dbi; acyl-CoA-binding protein isoform X1 [KO:K08762]
103183499  lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
103183498  lipoprotein lipase isoform X1 [KO:K01059] [EC:3.1.1.34]
103178869  acsl4a; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
103175318  long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
103178211  acsl1a; long-chain-fatty-acid--CoA ligase 1a isoform X1 [KO:K01897] [EC:6.2.1.3]
103186542  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
103183672  long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
103183485  acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 [KO:K15013] [EC:6.2.1.3]
103181022  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
103181008  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
103191285  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
103185291  scp2a; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
103177355  acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
103175663  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
103179753  peroxisomal acyl-coenzyme A oxidase 2 [KO:K10214] [EC:1.17.99.3]
103189456  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
103191252  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
103182964  acadl; LOW QUALITY PROTEIN: long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
103174736  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
103171584  angiopoietin-related protein 4 [KO:K08767]
103178101  angiopoietin-related protein 3 [KO:K08767]
103185828  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
103178084  plin2; perilipin-2 [KO:K17284]
103174906  adipoqa; adiponectin [KO:K07296]
103183017  adiponectin-like [KO:K07296]
103186641  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
103171639  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
103171656  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
103186404  gk; glycerol kinase [KO:K00864] [EC:2.7.1.30]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
cmk00071  Fatty acid degradation
cmk00120  Primary bile acid biosynthesis
cmk00564  Glycerophospholipid metabolism
cmk04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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