Entry
Name
PPAR signaling pathway
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Ortholog table
Orthology
K08745 solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-]
K08746 solute carrier family 27 (fatty acid transporter), member 2 [EC:6.2.1.- 6.2.1.3 ]
K08748 solute carrier family 27 (fatty acid transporter), member 5 [EC:6.2.1.7 ]
K08749 solute carrier family 27 (fatty acid transporter), member 6
K08750 fatty acid-binding protein 1, liver
K08751 fatty acid-binding protein 2, intestinal
K08752 fatty acid-binding protein 3, muscle and heart
K08753 fatty acid-binding protein 4, adipocyte
K08754 fatty acid-binding protein 5, epidermal
K08755 fatty acid-binding protein 6, ileal (gastrotropin)
K08756 fatty acid-binding protein 7, brain
K07294 peroxisome proliferator-activated receptor alpha
K08524 retinoid X receptor alpha
K08525 retinoid X receptor beta
K08526 retinoid X receptor gamma
K04504 peroxisome proliferator-activated receptor delta
K08530 peroxisome proliferator-activated receptor gamma
K08761 phospholipid transfer protein
K00029 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40 ]
K08762 diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein)
K08763 oxidised low-density lipoprotein receptor 1
K10214 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3 ]
K08765 carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21 ]
K19523 carnitine O-palmitoyltransferase 1, muscle isoform [EC:2.3.1.21 ]
K19524 carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21 ]
K06086 sorbin and SH3 domain containing protein 1
K01388 matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7 ]
K08769 solute carrier family 25 (mitochondrial uncoupling protein), member 7
Compound
Reference
Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
Journal
Nippon Rinsho 63:557-64 (2005)
Reference
Authors
Fujii H.
Title
[PPARs-mediated intracellular signal transduction]
Journal
Nippon Rinsho 63:565-71 (2005)
Reference
Authors
Takada I, Kato S.
Title
[PPARs target genes]
Journal
Nippon Rinsho 63:573-7 (2005)
Reference
Authors
Inoue H.
Title
[Endogenous ligands for PPARs]
Journal
Nippon Rinsho 63:578-83 (2005)
Reference
Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
Journal
Reference
Authors
Desvergne B, Michalik L, Wahli W.
Title
Transcriptional regulation of metabolism.
Journal
Reference
Authors
Mandard S, Muller M, Kersten S.
Title
Peroxisome proliferator-activated receptor alpha target genes.
Journal
Reference
Authors
Desvergne B, Wahli W.
Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Journal
Reference
Authors
Savage DB.
Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
Journal
Reference
Authors
Semple RK, Chatterjee VK, O'Rahilly S.
Title
PPAR gamma and human metabolic disease.
Journal
Reference
Authors
Lehrke M, Lazar MA.
Title
The many faces of PPARgamma.
Journal
Reference
Authors
Hauner H.
Title
The mode of action of thiazolidinediones.
Journal
Related pathway
ko00120 Primary bile acid biosynthesis
ko00564 Glycerophospholipid metabolism
ko04920 Adipocytokine signaling pathway
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