KEGG   ORTHOLOGY: K10226
Entry
K10226                      KO                                     
Symbol
FADS2
Name
acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]
Pathway
map00592  alpha-Linolenic acid metabolism
map01040  Biosynthesis of unsaturated fatty acids
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01212  Fatty acid metabolism
map03320  PPAR signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00592 alpha-Linolenic acid metabolism
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
   01040 Biosynthesis of unsaturated fatty acids
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.3  acyl-CoA 6-desaturase
     K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Lipid biosynthesis proteins [BR:ko01004]
 Desaturase
  Front-end
   K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Other DBs
RN: R03814 R07861 R07933 R11110 R11111 R12167 R12168 R12170 R12171 R12172
GO: 0016213
Genes
HSA: 9415(FADS2)
PTR: 451244(FADS2)
PPS: 100980611(FADS2)
GGO: 109024898(FADS2)
PON: 100190814(FADS2)
NLE: 100596455(FADS2)
MCC: 719037(FADS2)
MCF: 101926688(FADS2)
CSAB: 103234245(FADS2)
CATY: 105577581(FADS2)
PANU: 100126749(FADS2)
TGE: 112606127(FADS2)
RRO: 104679373(FADS2)
RBB: 108533600(FADS2)
TFN: 117080261(FADS2)
PTEH: 111524318(FADS2)
CJC: 100387410(FADS2)
SBQ: 101051429(FADS2)
CSYR: 103269267(FADS2)
MMUR: 105878617(FADS2)
LCAT: 123641268(FADS2)
OGA: 100953713(FADS2)
MMU: 56473(Fads2)
MCAL: 110285898(Fads2)
MPAH: 110322460(Fads2)
RNO: 83512(Fads2)
MCOC: 116103546(Fads2)
MUN: 110548092(Fads2)
CGE: 100757464(Fads2)
MAUA: 101844598(Fads2)
PLEU: 114703436(Fads2)
MORG: 121453878(Fads2)
AAMP: 119814598(Fads2)
NGI: 103729125(Fads2)
HGL: 101726663(Fads2)
CPOC: 100724176(Fads2)
CCAN: 109695673(Fads2)
DORD: 105993195 105995277(Fads2)
DSP: 122104886(Fads2)
NCAR: 124958641
OCU: 100352712(FADS2)
OPI: 101520480(FADS2)
TUP: 102475407(FADS2)
CFA: 483792(FADS2)
VVP: 112911087(FADS2)
VLG: 121472257(FADS2)
AML: 100470289(FADS2)
UMR: 103678231(FADS2)
UAH: 113246983(FADS2)
UAR: 123785126(FADS2)
ELK: 111149586
LLV: 125078518
MPUF: 101675571(FADS2)
ORO: 101364529(FADS2)
EJU: 114220204(FADS2)
ZCA: 113914859(FADS2)
MLX: 118015922(FADS2)
FCA: 101085071(FADS2)
PYU: 121043312(FADS2)
PBG: 122483864(FADS2)
PTG: 102968308(FADS2) 102969100
PPAD: 109246554(FADS2) 109261216
AJU: 106986967(FADS2) 106988351
BTA: 521822(FADS2)
BOM: 102275533(FADS2)
BIU: 109554370(FADS2)
BBUB: 102405983(FADS2)
CHX: 100861212 102171133(FADS2)
OAS: 101108497 101108615(FADS2)
ODA: 120874547(FADS2)
CCAD: 122431166(FADS2) 122451127
SSC: 444997(FADS2)
CFR: 102506325(FADS2)
CBAI: 105070113(FADS2)
CDK: 105091525(FADS2) 105104977
VPC: 102535510 102543923(FADS2)
BACU: 103000252(FADS2)
LVE: 103083143(FADS2)
OOR: 101275563(FADS2)
DLE: 111183883(FADS2)
PCAD: 114487991(FADS2)
PSIU: 116757879(FADS2)
ECB: 100062709(FADS2)
EPZ: 103543786 103567043(FADS2)
EAI: 106847560(FADS2)
MYB: 102261893(FADS2)
MYD: 102773468(FADS2)
MMYO: 118649000(FADS2)
MLF: 102433969
MNA: 107527684(FADS2)
PKL: 118707198(FADS2)
HAI: 109390019(FADS2)
DRO: 112317237(FADS2)
SHON: 118996917(FADS2)
AJM: 119043681(FADS2)
PDIC: 114499454(FADS2)
PHAS: 123829520(FADS2)
MMF: 118627539(FADS2)
RFQ: 117030358(FADS2)
PALE: 102894063(FADS2)
PGIG: 120600650(FADS2)
PVP: 105297786(FADS2)
RAY: 107501589(FADS2)
MJV: 108407763(FADS2)
TOD: 119250071(FADS2)
SARA: 101540602(FADS2)
LAV: 100677680
TMU: 101347025
DNM: 101419118(FADS2)
MDO: 100009895(FADS2)
GAS: 123252763(FADS2)
SHR: 100930034(FADS2)
PCW: 110195307(FADS2)
OAA: 100086288
GGA: 423122(FADS2)
PCOC: 116239008(FADS2)
MGP: 100549977
CJO: 107314439(FADS2)
NMEL: 110400735(FADS2)
APLA: 101798758(FADS2)
ACYG: 106033870
AFUL: 116489695(FADS2)
TGU: 100222881(FADS2)
LSR: 110484926(FADS2)
SCAN: 103822123(FADS2)
PMOA: 120499564(FADS2)
OTC: 121339150(FADS2)
PRUF: 121354750(FADS2)
GFR: 102040567(FADS2)
FAB: 101810111(FADS2)
PHI: 102112585(FADS2)
PMAJ: 107205402(FADS2)
CCAE: 111930632
CCW: 104697641(FADS2)
ETL: 114067866
ZAB: 102066733
FPG: 101910606(FADS2)
FCH: 102058085(FADS2)
CLV: 102098615(FADS2)
EGZ: 104122147
NNI: 104009393(FADS2)
PLET: 104623342
ACUN: 113481354
TALA: 104369427(FADS2)
PADL: 103925785(FADS2)
ACHC: 115352166(FADS2)
AAM: 106490046
AROW: 112978021
NPD: 112948004(FADS2)
DNE: 112991695(FADS2)
ASN: 102382989
AMJ: 102563693(FADS2)
CPOO: 109318131
GGN: 109295789(FADS2)
PSS: 102460236(FADS2)
CMY: 102933275
CPIC: 101936434(FADS2)
TST: 117877425(FADS2)
CABI: 116830902(FADS2)
MRV: 120403580
ACS: 100551818(fads2)
PVT: 110086191(FADS2)
SUND: 121930482
PBI: 103050551(FADS2)
PMUR: 107300095
TSR: 106538426(FADS2)
PGUT: 117667019
VKO: 123021211
PMUA: 114600538
ZVI: 118089026
GJA: 107108854(FADS2)
STOW: 125427058
XLA: 399058(fads2.S) 446688(fads2.L)
XTR: 100145314(fads2)
NPR: 108794176(FADS2)
RTEM: 120917257(FADS2)
BBUF: 120981189(FADS2)
BGAR: 122920199(FADS2)
DRE: 140615(fads2)
SRX: 107754339
PPRM: 120474050(fads2)
MAMB: 125246733(fads2)
SMEO: 124392159 124392817(fads2)
AMEX: 103027972(fads2)
EEE: 113588191(fads2)
LCO: 104937137(fads2)
NCC: 104956187(fads2)
CGOB: 115010175(fads2)
ELY: 117262279(fads2)
PLEP: 121949837(fads2)
ECRA: 117949003
PFLV: 114560045 114560046(fads2)
PPUG: 119195671(fads2)
CUD: 121515126(fads2)
ALAT: 119023767(fads2)
KMR: 108230083(fads2) 108230084
AOCE: 111582148(fads2)
CSEM: 103380276(fads2)
POV: 109623584(fads2)
SSEN: 122760510 122775367(fads2)
HHIP: 117763209(fads2) 117777344
HSP: 118109441(fads2)
LCF: 108886851(fads2)
SDU: 111229900(fads2)
SLAL: 111666947(fads2)
XGL: 120793558(fads2)
HCQ: 109507604(fads2)
BPEC: 110167702(fads2)
BSPL: 114856803(fads2)
SASA: 100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b)
SALP: 112071110
ELS: 105018065(fads2)
AANG: 118215202(fads2)
PSPA: 121330343
ARUT: 117434917(fads2)
LCM: 102349949(FADS2)
CMK: 103174861
RTP: 109937250(fads2)
BFO: 118428221
BBEL: 109463898
DPA: 109544444
OBI: 106867675
OSN: 115223335
AQU: 100632154
 » show all
Reference
PMID:9867867
  Authors
Cho HP, Nakamura MT, Clarke SD
  Title
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
  Journal
J Biol Chem 274:471-7 (1999)
DOI:10.1074/jbc.274.1.471
  Sequence
[hsa:9415] [mmu:56473]
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