KEGG   PATHWAY: cpau00260
Entry
cpau00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Cupriavidus pauculus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cpau00260  Glycine, serine and threonine metabolism
cpau00260

Module
cpau_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cpau00260]
cpau_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cpau00260]
cpau_M00621  Glycine cleavage system [PATH:cpau00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cupriavidus pauculus [GN:cpau]
Gene
EHF44_16525  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EHF44_11010  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EHF44_12770  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EHF44_09885  homoserine kinase [KO:K02204] [EC:2.7.1.39]
EHF44_12775  threonine synthase [KO:K01733] [EC:4.2.3.1]
EHF44_09850  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
EHF44_09535  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EHF44_21185  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
EHF44_04810  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
EHF44_11135  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
EHF44_03365  glycerate kinase [KO:K11529] [EC:2.7.1.165]
EHF44_06155  glycerate kinase [KO:K11529] [EC:2.7.1.165]
EHF44_04125  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
EHF44_03295  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
EHF44_26495  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EHF44_05550  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EHF44_18860  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EHF44_27665  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EHF44_02050  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
EHF44_15210  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EHF44_16030  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
EHF44_25245  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
EHF44_06050  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EHF44_06060  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EHF44_24860  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EHF44_18940  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EHF44_15510  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EHF44_12515  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EHF44_06055  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EHF44_25000  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EHF44_17805  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EHF44_23900  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EHF44_06045  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EHF44_03620  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EHF44_27645  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
EHF44_20530  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
EHF44_11040  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EHF44_11030  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cpau00010  Glycolysis / Gluconeogenesis
cpau00020  Citrate cycle (TCA cycle)
cpau00230  Purine metabolism
cpau00250  Alanine, aspartate and glutamate metabolism
cpau00270  Cysteine and methionine metabolism
cpau00290  Valine, leucine and isoleucine biosynthesis
cpau00300  Lysine biosynthesis
cpau00330  Arginine and proline metabolism
cpau00460  Cyanoamino acid metabolism
cpau00470  D-Amino acid metabolism
cpau00564  Glycerophospholipid metabolism
cpau00620  Pyruvate metabolism
cpau00630  Glyoxylate and dicarboxylate metabolism
cpau00640  Propanoate metabolism
cpau00680  Methane metabolism
cpau00860  Porphyrin metabolism
cpau00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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