KEGG   PATHWAY: csab00591
Entry
csab00591                   Pathway                                
Name
Linoleic acid metabolism - Chlorocebus sabaeus (green monkey)
Class
Metabolism; Lipid metabolism
Pathway map
csab00591  Linoleic acid metabolism
csab00591

Other DBs
GO: 0043651
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103216014  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
103216299  CYP2C19; cytochrome P450 family 2 subfamily C member 19 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
103216301  CYP2C9; cytochrome P450 family 2 subfamily C member 9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
103216303  CYP2C8; cytochrome P450 family 2 subfamily C member 8 [KO:K17718] [EC:1.14.14.1]
103216308  [KO:K17718] [EC:1.14.14.1]
103220573  PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
103223182  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
103223308  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
103224719  CYP2J2; cytochrome P450 family 2 subfamily J member 2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
103225460  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
103225462  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
103225463  PLA2G2D; phospholipase A2 group IID [KO:K01047] [EC:3.1.1.4]
103225465  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
103225466  PLA2G2A; phospholipase A2 group IIA [KO:K01047] [EC:3.1.1.4]
103225968  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
103228738  [KO:K01047] [EC:3.1.1.4]
103230418  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
103233696  PLA2G16; phospholipase A2 group XVI [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103233700  HRASLS2; HRAS like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
103235528  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
103236105  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
103239247  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
103242192  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
103245329  CYP1A2; cytochrome P450 family 1 subfamily A member 2 [KO:K07409] [EC:1.14.14.1]
103245774  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
103245776  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
103245777  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
103245979  CYP2E1; cytochrome P450 family 2 subfamily E member 1 [KO:K07415] [EC:1.14.14.-]
103246100  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
103246766  [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C01595  Linoleate
C03242  Dihomo-gamma-linolenate
C04056  Rumenic acid
C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
C07289  Crepenynate
C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  (7S,8S)-DiHODE
C14762  13(S)-HODE
C14765  13-OxoODE
C14766  9-OxoODE
C14767  9(S)-HODE
C14825  9(10)-EpOME
C14826  12(13)-EpOME
C14827  9(S)-HPODE
C14828  9,10-DHOME
C14829  12,13-DHOME
C14831  8(R)-HPODE
C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  9,12,13-TriHOME
C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  9,10,13-TriHOME
C14836  9,10-12,13-Diepoxyoctadecanoate
C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  5S,8R-DiHODE
C22918  (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
DOI:10.1016/j.toxlet.2003.11.002
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
DOI:10.1073/pnas.1631086100
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
DOI:10.1054/plef.2002.0413
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
DOI:10.1074/jbc.273.33.20744
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
DOI:10.1104/pp.110.3.807
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
DOI:10.1016/0304-4165(96)00037-2
Related
pathway
csab00590  Arachidonic acid metabolism
KO pathway
ko00591   

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