KEGG   PATHWAY: cvf04350
Entry
cvf04350                    Pathway                                
Name
TGF-beta signaling pathway - Charadrius vociferus (killdeer)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
cvf04350  TGF-beta signaling pathway
cvf04350

Other DBs
GO: 0007179
Organism
Charadrius vociferus (killdeer) [GN:cvf]
Gene
104281785  BMP5; bone morphogenetic protein 5 [KO:K04663]
104281911  TGIF1; homeobox protein TGIF1 [KO:K19383]
104282065  INHBC; inhibin beta C chain [KO:K22688]
104282150  NOG; noggin [KO:K04658]
104282313  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
104282498  [KO:K21283]
104282962  RHOA; transforming protein RhoA [KO:K04513]
104283557  [KO:K26316]
104283724  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
104283792  HFE2; hemojuvelin [KO:K23100]
104283917  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104284287  DCN; decorin [KO:K04660]
104284358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104284385  NCOR1; LOW QUALITY PROTEIN: nuclear receptor corepressor 1 [KO:K04650]
104284456  [KO:K16622]
104284607  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
104284797  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
104284963  TFRC; transferrin receptor protein 1 [KO:K06503]
104284994  CHRD; chordin [KO:K04657]
104285096  THBS1; thrombospondin-1 [KO:K16857]
104285280  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
104285554  LRRC32; leucine-rich repeat-containing protein 32 [KO:K26316]
104285850  NODAL; nodal homolog [KO:K04666]
104285921  SKIL; ski-like protein isoform X1 [KO:K18499]
104285997  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
104286077  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
104286116  TMEM53; transmembrane protein 53 [KO:K28359]
104286461  AMH; muellerian-inhibiting factor [KO:K04665]
104286721  GDF7; growth/differentiation factor 7 [KO:K20013]
104286757  NRROS; negative regulator of reactive oxygen species [KO:K26317]
104286762  [KO:K14736]
104286792  BMP6; bone morphogenetic protein 6 [KO:K16620]
104286819  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
104286820  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
104286869  PITX2; pituitary homeobox 2 [KO:K04686]
104287088  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
104287141  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
104287383  BMP2; bone morphogenetic protein 2 [KO:K21283]
104287432  FBN1; fibrillin-1 [KO:K06825]
104287603  RBL1; retinoblastoma-like protein 1 [KO:K04681]
104287627  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
104287770  [KO:K06847]
104287891  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
104287935  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
104288041  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
104288112  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
104288155  GREM1; gremlin-1 isoform X1 [KO:K23318]
104288206  TGFB3; transforming growth factor beta-3 [KO:K13377]
104288349  RGMA; repulsive guidance molecule A [KO:K23096]
104288491  [KO:K04388] [EC:2.7.11.30]
104288492  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
104288508  INHBB; inhibin beta B chain [KO:K22687]
104288899  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
104288925  IFNG; interferon gamma [KO:K04687]
104288957  LEMD3; inner nuclear membrane protein Man1 [KO:K19410]
104289233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104289308  FMOD; fibromodulin [KO:K08121]
104289459  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
104289801  [KO:K21283]
104290161  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
104290338  INHBA; inhibin beta A chain [KO:K04667]
104290508  SKI; ski oncogene [KO:K26503]
104290598  RGMB; RGM domain family member B [KO:K06847]
104290809  [KO:K19558]
104291043  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104291492  SMAD1; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 1 [KO:K04676]
104291610  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
104291621  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104291773  SMAD5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
104291807  [KO:K04661]
104291926  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
104292548  E2F5; transcription factor E2F5 [KO:K04682]
104292687  GDF5; growth/differentiation factor 5 [KO:K04664]
104292712  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
104293525  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
104293730  [KO:K17693]
104293949  BMP7; bone morphogenetic protein 7 [KO:K16621]
104294051  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
104294076  GREM2; gremlin-2 [KO:K23318]
104294310  BMP4; bone morphogenetic protein 4 [KO:K04662]
104294574  FST; follistatin [KO:K04661]
104294674  TGFB2; transforming growth factor beta-2 [KO:K13376]
104294685  LEFTY1; left-right determination factor 1 [KO:K04668]
104294688  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
104294822  E2F4; transcription factor E2F4 [KO:K04682]
104295080  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
104295278  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104295307  CUL1; cullin-1 [KO:K03347]
104295359  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
104295489  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
104295769  NEO1; neogenin isoform X1 [KO:K06766]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
cvf04010  MAPK signaling pathway
cvf04110  Cell cycle
cvf04120  Ubiquitin mediated proteolysis
cvf04210  Apoptosis
KO pathway
ko04350   

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